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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Is it confirmed that jabs are for life?

126 replies

RoundandSad · 31/10/2025 17:32

Hi

I posted here a year or so ago thinking of trying this but I had a terrible experience with Saxenda so decided against it

Still big have lost about 5lb

over the last year, it looks like you have to take it forever

Reconsidering you guys will understand,. I feel like being fat is a problem in every walk of life.

But that's an expense that has to be paid forever, isn't it?

OP posts:
Thelankyone · 31/10/2025 20:05

PlaceIntheClouds · 31/10/2025 19:49

It depends if you have any willpower or not.

Basically the jabs stop you from wanting to eat. As soon as you stop injecting yourself you are down to the power of your mind alone.

The problem is most people have learned nothing about good nutrition or willpower whilst taking the jabs.

Surely no one is this misinformed. Not still?

Thelankyone · 31/10/2025 20:05

InfoSecInTheCity · 31/10/2025 20:01

Its useful to understand what Mounjaro does and how it works, because on all of these kind of threads I see lots of misinformation about how it just stops you being hungry, which isnt the full picture.

it mimics two natural hormones in your body — GLP-1 and GIP the effect of this is:

• Improves insulin response: It helps your pancreas release insulin when needed and makes your body more sensitive to it. This prevents your body storing the excess sugar as fat.
• Lowers sugar production: It stops your liver from making too much sugar.
• Tells your brain you’re full: It sends signals that make you feel like you’ve just eaten, helping reduce hunger and cravings.
• Slows digestion: Food stays in your stomach longer, so you feel full for more time.

Its also interesting that studies show that weight re-gain following stopping Mounjaro is the same as weight gain following significant loss by any other method - gastric bypass/sleeve, calorie counting, keto, atkins, slimming world………

My situation is slightly different, I take Mounjaro because I’m diabetic and a combo of insulin and metformin wasn’t doing the job, Mounjaro however has been miraculous in reducing my sugar levels and I’ve lost 6 and a half stone. I’ll keep taking it for as long as they let me.

Edited

Great post.

Thelankyone · 31/10/2025 20:07

SwirlyShirly · 31/10/2025 20:01

I am only on lowest dose of Wegovy - titrating up this weekend. I have lost about 10lbs in the last 4 weeks. I’d like to lose another 2.5-3st for a total loss of 17st overall. I don’t know if I will be able to do it due to the amount of loose skin and lipodema tissue I have, but I plan to stay on it as long as I can afford to because of the other positive ‘side effects’ I have noted. On top of the weight loss, I haven’t drank any alcohol at all, and that was getting to be a bit of a problem pre-jab. I’ve had fleeting cravings, but they have been fairly easy to ignore.

Wow, well done that’s a huge achievement.😍

NikkiPotnick · 31/10/2025 20:10

FlowersFawb · 31/10/2025 17:46

I don't plan to be on it for life. I find it quite odd when people say that tbh. I've lpst 6 stone since January and hit my goal weight today of 11 stone. I am tapering off and will be done in January 26. I think the jabs are a tool but people should be able to maintain weightloss with better habits.

I find it odd that you think your 'should' has any bearing on other people's bodies.

Filigreecurtain · 31/10/2025 20:13

@PlaceIntheClouds ,its got nothing to do with willpower, or knowledge of nutrition, I know all about both, it has got everything to do with this drug regulating leptin and ghrelin in people who don't have balance in these hormones. It also disrupts the dopamine pathway, so that people who use food to get a hit from dopamine ie, people with adhd/ bed, don't do that anymore because their brain isn't telling them to. If losing weight was just about willpower and knowledge of nutrition, kindly most of us wouldn't be fat fuckers in the first place would we. Even the the thickest of folk know that eating cake, rather than lettuce will make you fat, but in some people there's a never ending noise that says eat, eat, eat, and this drug makes that go away. In people who have their hormones balanced they find it relatively simple to eat when hungry and stop when not. Mj levels the playing field.

Thelankyone · 31/10/2025 20:23

Filigreecurtain · 31/10/2025 20:13

@PlaceIntheClouds ,its got nothing to do with willpower, or knowledge of nutrition, I know all about both, it has got everything to do with this drug regulating leptin and ghrelin in people who don't have balance in these hormones. It also disrupts the dopamine pathway, so that people who use food to get a hit from dopamine ie, people with adhd/ bed, don't do that anymore because their brain isn't telling them to. If losing weight was just about willpower and knowledge of nutrition, kindly most of us wouldn't be fat fuckers in the first place would we. Even the the thickest of folk know that eating cake, rather than lettuce will make you fat, but in some people there's a never ending noise that says eat, eat, eat, and this drug makes that go away. In people who have their hormones balanced they find it relatively simple to eat when hungry and stop when not. Mj levels the playing field.

There is no point, they just want to feel superior,

Newsenmum · 31/10/2025 20:24

Not necessarily. If you maintained when big hopefully you maintain again when not. The idea is that when you have the reduced hunger you make the lifestyle changes so theyre all in place when youre done.

DingDongJingle · 31/10/2025 20:29

Newsenmum · 31/10/2025 20:24

Not necessarily. If you maintained when big hopefully you maintain again when not. The idea is that when you have the reduced hunger you make the lifestyle changes so theyre all in place when youre done.

Yes this is what happened to me. I put on weight after a very specific chain of events which meant I was practically bed bound for 18 months. I then maintained that ‘too high’ weight for 3 years. I found it insanely difficult to lose weight, but wasn’t putting any more on once my circumstances changed for the better.
i lost 3.5 stone with MJ then came off. I have found it easy to maintain that new lower weight. I have concluded that my body finds it easy to consume the same amount of calories needed to maintain my weight (whatever that is), but very difficult to burn more calories than I consume (I am exhausted, starving and vile tempered when I try and do this).

uglyfeet · 31/10/2025 20:32

Don’t know, I said I didn’t want to use tax payers money to fund my diabetic medication in the near future when I become unemployed now I have had Metformin stopped and a cavalier attitude from so called diabetic nurses at my gp surgery so they said stop it.

Last jab 17 Oct - 1lb off this week.

Determined to make do without for next 3 months. It’s hard but got to be done.
I need answers whether this just masks someones diabetes.

Don’t know I ask why is there a rise in lymphoedema and lipodema or why it is acknowledged more today than ever before but no one is able to say why.

Whyherewego · 31/10/2025 20:33

OP please look up what @Filigreecurtain posted about. There are some good podcasts you can listen to from real experts. There's a Zoe podcast with Andrew Jenkinson which i thought was very helpful explaining these hormones.
But basically GLP1s are helpful and work but it's important to understand what the body is also doing to stop you from losing weight and to get you back to the weight it thinks you should be. Have a listen it's very enlightening

RoundandSad · 01/11/2025 00:06

@Whyherewego I have never listened to anything that tells me anything useful

what you have said sounds like all the reasons that your body holds onto weight yes I know that but I'm still happy to try

Eating protein and veggies mostly like I said I have lost weight but not much it's very slow although maybe in a years time it will be better

OP posts:
IDontHateRainbows · 01/11/2025 00:21

For me, yes, but not necessarily to lose weight/ maintain a low weight. To stop the obsession with food which was blighting my life.

babylone · 01/11/2025 06:15

Not sure who has confirmed it?
ive been on MJ for 6 months and i am on way to my 3rd stone loss.
when i jabbed for the first time, in the first 24hrs, what impressed me most wasnt the food nois suppression, but how my perimenopausal brain fog lifted, my mood slightly lifted, my energy level slightly increased. Then the food suppression came in.
i remember the first few weeks being so impressed that i used to say that whether or not i was going to lose weight, i want to stay on this!
now does it mean i had high level of inflammation or something i dont know. Generally healthy, 49yo started with a BMI of 36.
now i often think that i am getting younger. My body feels younger with less weight and i feel more positive and in better shape than before. It is hard to know what is the part of mj and what is because of the weight loss.
my DH started with me and has felt the same way. A few weeks ago he stopped cold turkey for 3 weeks - just to see what would happen. The food noise came back, his motivation to go to the gym decreased and after football (he plys twice a week) he was sore again, just like before MJ.
we are really thinking about microdosing long term. I am taking 2mg every 4 days so i kind have “microdose” the whole time. I buy 7.5ml pens (will buy a 10ml pen next time). DH is on 12.5 but he is thinking about microdosing once he reaches GW.
sometimes newspaper reports that MJ (or is it weight loss? Or is it both?) are found to protect liver, kidney, cancers, dementia… why not stay on it for life??

MarmaladeTeepee · 01/11/2025 06:38

I think you have to do what's best for you. For me, I think that means being on them for life although I'm open to switching to wegovy (or whatever new options come available in the future) from mounjaro once I hit maintenance. I didn't realise how bad my negative thought patterns were until mounjaro took them away - no more constant battles with myself over food, no more unhealthy dopamine seeking behaviours, no more constant dwellings on all my past failures... No way do I want to go back to that.

Incognitoburrito88 · 01/11/2025 07:37

PlaceIntheClouds · 31/10/2025 19:49

It depends if you have any willpower or not.

Basically the jabs stop you from wanting to eat. As soon as you stop injecting yourself you are down to the power of your mind alone.

The problem is most people have learned nothing about good nutrition or willpower whilst taking the jabs.

It makes me so sad to read people on this board still touting the horrible ‘willpower’ rhetoric. Maintaining weight post diet is so much more than willpower - I really recommend this podcast which describes very eloquently why people regain weight post diet - it’s not just because they are weak minded fatties. https://podcasts.apple.com/gb/podcast/zoe-science-nutrition/id1611216298?i=1000730987257

OP I have lost 3 stone over 6 months on a low dose of Mounjaro - side effects were fairly minimal. I’m in my 40’s and healthy and I don’t like the thought of having to be on it for the rest of my life - that could be another 50 years! I’m now decreasing my dose and spreading out the duration of dosing. I’m allowing myself to experience more hunger and learning how to manage that. I’ve changed my diet and am continuing to change it and am also fully committed to the slimpod program. I think I will be able to come off and maintain at some point in the future but it’s going to be hard work.

Also there is a lot of evidence out there now to suggest that OMAD isn’t a great eating pattern for peri and post menopausal woman - I used to be a big IF advocate but apparently most of the research was done on men and in fact in older woman fasting increases cortisol levels which is linked to weight gain and may outweigh the positives of OMAD.

Thelankyone · 01/11/2025 07:46

babylone · 01/11/2025 06:15

Not sure who has confirmed it?
ive been on MJ for 6 months and i am on way to my 3rd stone loss.
when i jabbed for the first time, in the first 24hrs, what impressed me most wasnt the food nois suppression, but how my perimenopausal brain fog lifted, my mood slightly lifted, my energy level slightly increased. Then the food suppression came in.
i remember the first few weeks being so impressed that i used to say that whether or not i was going to lose weight, i want to stay on this!
now does it mean i had high level of inflammation or something i dont know. Generally healthy, 49yo started with a BMI of 36.
now i often think that i am getting younger. My body feels younger with less weight and i feel more positive and in better shape than before. It is hard to know what is the part of mj and what is because of the weight loss.
my DH started with me and has felt the same way. A few weeks ago he stopped cold turkey for 3 weeks - just to see what would happen. The food noise came back, his motivation to go to the gym decreased and after football (he plys twice a week) he was sore again, just like before MJ.
we are really thinking about microdosing long term. I am taking 2mg every 4 days so i kind have “microdose” the whole time. I buy 7.5ml pens (will buy a 10ml pen next time). DH is on 12.5 but he is thinking about microdosing once he reaches GW.
sometimes newspaper reports that MJ (or is it weight loss? Or is it both?) are found to protect liver, kidney, cancers, dementia… why not stay on it for life??

Edited

The mhra which is the uk version of the USA fda has approved it for life long use. The op’s question I think is poorly phrased, you don’t need to stay on, you don’t need to come off, it’s a personal choice.

on the anti ageing, they have found this in trials and now are doing new trials specifically on it.

on the report I read, basically it said every time we get ill or hurt ourselves, our cells do not fully recover. They carry a marker of that, which is inflammation in the main, this is ageing, it is the cumulative effect of every time we get a virus, or some damage ie too much fat, booze, whatever,

when you remove that inflammation, the cells are able to regenerate, the inflammation reduces our cells ability to fully regenerate, so when the cells fully regenerate, ageing either slows, halts, or in some people reverse. It’s different for everyone.

I’m talking internally, our organs. Not your skin ie wrinkles, that’s about collagen etc and a different thing,

so yes, it is now thought it has an anti ageing effect, and entering trials for this specifically, it appears the “fountain of youth” isn’t about our appearance, but our organs internally, and they may have found it, it would require tweaking if we get to the stage where it is taken for this purpose.

we need to remember this is just a synthetic peptide, one we produce naturally, but that we produce less of as we age, and I guess some folks never produce enough of, but it’s a very important one. And by taking more of it, our bodies start to work optimally again.

DingDongJingle · 01/11/2025 07:48

sometimes newspaper reports that MJ (or is it weight loss? Or is it both?) are found to protect liver, kidney, cancers, dementia… why not stay on it for life??

The obvious answer is that for many people, they just can’t afford to.

ResusciAnnie · 01/11/2025 07:50

PlaceIntheClouds · 31/10/2025 19:49

It depends if you have any willpower or not.

Basically the jabs stop you from wanting to eat. As soon as you stop injecting yourself you are down to the power of your mind alone.

The problem is most people have learned nothing about good nutrition or willpower whilst taking the jabs.

Pray tell where you found such evidence?

Lifeisabeach1 · 01/11/2025 07:58

Filigreecurtain · 31/10/2025 19:35

If I could afford to stay on it for life I would, it's simultaneously calmed my adhd, stopped my alcohol addiction, soothed inflammation, as well as the weight loss, it's criminal that this drug is only for the well off. I can't afford it any more so my behaviour has now tipped into eating disorder territory whereby I'm severely restricting food, and obsessing about every mouthful, I'm underweight and petrified of putting the weight back on. If I could take an affordable weekly 5 ml dose and go about my day I'd be happy, this drug is so much more than weight loss.

It’ll come off brand soon and be much better value for money.

I agree, it does more for me than my adhd medication does! It stops the dopamine hunting and subsequent blood sugar crashes and handovers!

Sprogonthetyne · 01/11/2025 08:08

I was on it for 6 months, but stopped because it was causing me extreme tiredness, to the extent I was bearly functioning. In that time I lost 15kg, which put me about half way to target weight. I've been off 6 months and have remained a similar weight to when I stopped.

If relevant, I gained the excess weight quite quickly during a stressful life event, but was usually a consistent weight before and after that. So that could be linked to why I've gone back to a static (but lower) weight.

Thelankyone · 01/11/2025 08:22

Sprogonthetyne · 01/11/2025 08:08

I was on it for 6 months, but stopped because it was causing me extreme tiredness, to the extent I was bearly functioning. In that time I lost 15kg, which put me about half way to target weight. I've been off 6 months and have remained a similar weight to when I stopped.

If relevant, I gained the excess weight quite quickly during a stressful life event, but was usually a consistent weight before and after that. So that could be linked to why I've gone back to a static (but lower) weight.

That’s a shame for you. Everyone reacts differently to all medication. For example I was on blood pressure meds when I was fat, and ones which are hard on the kidneys, tests showed no impact and I could tolerate even a high dose, where as my sister in law, had to come off v quickly as her kidneys were being impaired at the lowest dose.

I think even 15 percent of people have no impact from these meds it jist doesn’t work for them, like injecting water, and of course 20 percent of people have side effects, usually minor gastro issues, 80 percent none.

millions of people take nurofen regularly, but 2000people die a year on average taking it, we all react differently to medication and if you fall into the small bucket who can’t tolerate it is always best to stop.

Iwanttoliveinagardencentre · 01/11/2025 08:36

I would have stayed on mounjaro for life if the cost hadn’t increased so much.
I have lost 9 stones. Had no side effects.

I’ve always had a fast through put in my digestive system and this has been exacerbated by immune related colitis as a permanent unpleasant side effect of cancer treatment.

Pre mounjaro food moved through my body very fast to the degree that I would only eat at home so I knew a toilet was available.

I think my fast digestion contributed to my having no “full” feeling and was therefore a big factor in my eating too much.

Whilst on mounjaro my digestion was normal and I needed a once daily poo.

blackwhitepink · 01/11/2025 08:41

SpottyAardvark · 31/10/2025 17:43

Of course not.

The purpose of the drugs is that they are a tool to help you lose weight & get down to a healthy weight. They also give you the space to change your attitude to food and establish healthy eating & exercise habits which will allow you to maintain that healthy weight without drugs.

The idea that none of us knew what to do before Mounjaro is hilarious. I have spent YEARS doing exactly this and never been able to maintain it or get my weight down enough. It’s like Mounjaro flicked a switch where I was able to do what I knew I needed to do. I’m not learning what to do, lack of education was never my problem. Just lack of ability.

Sprogonthetyne · 01/11/2025 08:41

Thelankyone · 01/11/2025 08:22

That’s a shame for you. Everyone reacts differently to all medication. For example I was on blood pressure meds when I was fat, and ones which are hard on the kidneys, tests showed no impact and I could tolerate even a high dose, where as my sister in law, had to come off v quickly as her kidneys were being impaired at the lowest dose.

I think even 15 percent of people have no impact from these meds it jist doesn’t work for them, like injecting water, and of course 20 percent of people have side effects, usually minor gastro issues, 80 percent none.

millions of people take nurofen regularly, but 2000people die a year on average taking it, we all react differently to medication and if you fall into the small bucket who can’t tolerate it is always best to stop.

Tbf, I still consider it an overall success. In the 6 month I took it I went from obese to a bit tubby but OK, which I'm happy with. If i didn't have such a busy life and need the energy to get stuff done, maybe I could have managed the tiredness for longer, but it was no longer working out with me/ my lifestyle. For me it made a positive change without being a lifelong commitment

HansHolbein · 01/11/2025 08:42

I’ll be on it for life. There are no ‘underlying’ issues to fix or therapy to address. It treats my PCOS.

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