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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

On 7.5mg and not lost all month. Should I go up?

17 replies

ChocolateBoxCottage · 28/10/2025 10:28

I'm on a new pen so I'm not sure if it's the pen or I'm just stalling. I started back in April and have gone up to 7.5 before but I then go on holidays etc and go back down to 5mg and normally have slow but steady losses on that.

In 6 months I have only lost 2 stone in total and my bmi is now 32. So no dramatic losses and some gains during three holidays. I have done 3 weeks of 7.5mg with this pen and if anything gained 2lbs over the month ( no holidays, no break in injections, eating the same, no hunger etc).

Is it time to move up again? The only other I can think of is to skip a week to reset. Or pen is a bit dodgy as one pen came without a it's normal wool pack and ice during the August fiasco. This might the pen?

OP posts:
northernlight20 · 28/10/2025 10:56

what are you eating? you need to be eating in a deficit to lose weight. i recommend the nutracheck app to keep an eye on calories. ive been on mounjaro since march and calorie counting and lost just shy of 5 n half stones. definitely take a look at calorie intake.

SilenceInside · 28/10/2025 11:03

If you are still getting the effects of the medication, so lower appetite, feeling fuller quicker and for longer etc, then moving up isn't necessary. And it would show that the medication is working as intended, and not somehow defective due to getting too warm during delivery.

If you are eating the same, but staying the same weight or even gaining, then I would look at your TDEE and current calorie total. It sounds like you might need to look at lowering your calorie total, or upping exercise or both.

Skipping a week doesn't seem to have any benefits at all, and I can't see how it could reset anything.

ChocolateBoxCottage · 28/10/2025 11:14

I'm not tracking my calories religiously. Just having two small meals a day ( intermittent fasting with no snacks) so my eating has been much the same since April. I will track my calories for the week and see what I'm eating.

OP posts:
ChocolateBoxCottage · 28/10/2025 11:20

I still never hungry and feel full quicker but all the other side effects have gone now. Normally when I go up a dose I get heartburn, feel sick etc but not on this pen. It's got three doses left so will see how I get on lowering my calories. My TDEE is 1776 and there's no way I'm exceeding that either. Very odd. I'm going for a very long walk today

OP posts:
spoonbillstretford · 28/10/2025 11:21

I didn't lose much on 7.5mg either and did better on 10mg.

spoonbillstretford · 28/10/2025 11:22

I tracked everything to start with. If I stop losing weight now I go back to tracking and usually I've been eating a bit more than I thought and after tracking for a bit it starts to go down again.

jaelato1 · 28/10/2025 11:35

I actually think you need to eat a bit more because i think your body has slow its metabolism in response to a prolonged calorie deficit to conserve energy. Sometime you have trick your body when we plateau, eat a bit more more than you normally would this week if you can.

ChocolateBoxCottage · 28/10/2025 11:41

jaelato1 · 28/10/2025 11:35

I actually think you need to eat a bit more because i think your body has slow its metabolism in response to a prolonged calorie deficit to conserve energy. Sometime you have trick your body when we plateau, eat a bit more more than you normally would this week if you can.

This is what I'm worried about to be honest. I will track and see what's going on. Yesterday I didn't even feel like eating at any point and today is injection day

OP posts:
spoonbillstretford · 28/10/2025 11:48

It depends on how much you lose, I guess, but I've lost just over 30lbs and am now a healthy BMI. I still lose 1lb a week ish averaging 1400-1500 calories a day which is what I've done from the start. Without tracking I creep up to 1700/1800 which would be fine for maintenance now but I'd like to lose another half a stone and then see how I feel, so I'm sticking to the lower amount for now.

Mysticmaiden · 28/10/2025 12:37

ChocolateBoxCottage · 28/10/2025 11:20

I still never hungry and feel full quicker but all the other side effects have gone now. Normally when I go up a dose I get heartburn, feel sick etc but not on this pen. It's got three doses left so will see how I get on lowering my calories. My TDEE is 1776 and there's no way I'm exceeding that either. Very odd. I'm going for a very long walk today

If your tdee is 1776 then you need to eat upto 1276 max to lose 1lb a week as the deficit is always -500 cals.
When I was bmi 32.4 my deficit was 1300, since bmi 25 its 1100 and at bmi 23.0 its 1019!
Is this a recent calculation? Are you also drinking plenty of water and focusing on protein and less carbs?

Mysticmaiden · 28/10/2025 12:40

jaelato1 · 28/10/2025 11:35

I actually think you need to eat a bit more because i think your body has slow its metabolism in response to a prolonged calorie deficit to conserve energy. Sometime you have trick your body when we plateau, eat a bit more more than you normally would this week if you can.

When I was on 15mg, it was far too strong for me but I finished off the pen. I could only manage 750-900 cals a day on it and I lost 61bs at bmi 25 so I don't believe that you need to eat more to lose. I'm now at bmi 23, went from bmi 23.5 to 23 in a month and lost 4lbs and I have to eat around 950-1200 for that.

jaelato1 · 28/10/2025 12:50

@Mysticmaiden Your circumstance is very different because in your situation you only ate smaller calories for a month due to the increased suppression, she has been on same calorie for 6months because she said she eats same things all the time so her body is used to expecting same deficit and therefore slowing her metabolism

Mysticmaiden · 28/10/2025 19:59

jaelato1 · 28/10/2025 12:50

@Mysticmaiden Your circumstance is very different because in your situation you only ate smaller calories for a month due to the increased suppression, she has been on same calorie for 6months because she said she eats same things all the time so her body is used to expecting same deficit and therefore slowing her metabolism

Edited

Lol I've been on it for a year eating max 1100 calories! Are you having a laugh trying to tell me what ive done in my journey???
I did one month on extremely low calories which I wouldn't recommend at all but mentioned it! The 15mg was an example of how much weight you can lose on very low calories. I've lost every week in that year other than a few weeks due to higher carbs. On Xmas day I ate 1000 calories where as most were eating 2-3 times that and that was only on 5mg. I've tracked everything and put in so much effort throughout my year. On weekends i eat 850-900 cals max a day. This is what leads to losses. Continued effort, low carb and tracking.
I've not had pasta, takeaways for a year, ive slogged hard and I was prediabetic. I'm now a size 10 so it is possible!

jaelato1 · 28/10/2025 21:10

I'm glad you are now a certified expert on mounjaro but science doesn't lie, metabolic adaptation is a thing, feel free to read it up.

PS I replied to you based on the example you gave initially before your epistle however, what works for you might not work for another because some people eat similar calories as you and still plateau but I guess your advice would be to eat even lesser calories 👍

Mysticmaiden · 28/10/2025 22:24

jaelato1 · 28/10/2025 21:10

I'm glad you are now a certified expert on mounjaro but science doesn't lie, metabolic adaptation is a thing, feel free to read it up.

PS I replied to you based on the example you gave initially before your epistle however, what works for you might not work for another because some people eat similar calories as you and still plateau but I guess your advice would be to eat even lesser calories 👍

No my advice which is clearly stated "I did one month on extremely low calories which I wouldn't recommend at all" and my first post "If your tdee is 1776 then you need to eat upto 1276 max to lose 1lb a week as the deficit is always -500 cals.
When I was bmi 32.4 my deficit was 1300, since bmi 25 its 1100 and at bmi 23.0 its 1019!
Is this a recent calculation? Are you also drinking plenty of water and focusing on protein and less carbs?" Which is science yes, calories in vs calories out which is proven many times vs your theory of "metabolic adaptation" which wouldn't explain how anorexic can starve themselves to death, as well as in third world countries where there is little food available..where is metabolic adaptation then. What is actually what you are referring to happens when a lot of body fat reserves are depleted and muscle is broken down and used to produce energy, this is when metabolism slows down to a lower rate to conserve muscle and to preserve organs and survive.
When a person has plenty of fat reserves body fat is used first aka ketosis and metabolism is not affected in fact mounjaro has shown to increase metabolism.
Also if someone is eating to their tdee then this is maintenance, not a deficit so of course they won't lose fat.
I'd prefer it if you didn't misquote me.
Oh and I am a registered healthcare scientist with 20+ years of experience in knowledge including anatomy and physiology.

Puddingpiper · 28/10/2025 22:33

@Mysticmaidengenuinely one of the best and put that in your pipe and smoke it replies I have seen for a long time

jaelato1 · 28/10/2025 22:59

@Mysticmaiden Nothing you’ve written disproves metabolic adaptation. You’ve actually described it perfectly, you’re just refusing to call it by its correct name.

The anorexic/famine example is moot because adaptation slows metabolism, it doesn’t prevent starvation.

And just because your body responded a certain way on very low calories doesn’t mean everyone else’s will. Many people hit plateaus on similar calories, it’s documented in actual research, not just personal anecdotes.

So no, I didn’t misquote you because I was replying to you solely to your response to me.
Yes, metabolic adaptation is real.
And no, the solution isn’t automatically eat even less because you assumed OP is eating to their tdee. Goodbye

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