More sensitive as weight has come off

[Orangesandlemons77]

I've lost about five stone over a year on mounjaro and have been up to 15mg through some of that time.

I'm starting to come off now but also finding I'm more sensitive to the lower doses.

Currently taking 5mg but felt nauseous and tricky to eat much so have gone down to 3.75 this week.

Anyone else finding the same? Why is this I wonder

I was just thinking that this morning, it’s very odd, I was on 10, I titrated down to 5, but find it just as strong, if not stronger than the 10 at times.

i have two things that I think now, firstly the mental health aspect, we are no longer dieting, so not focused so heavily on not eating over our cal allowance and any twinge of hunger , but now eating to maintenance, with no placebo effect, we have relaxed, and can feel the real effect of the drugs.

secondly we didn’t need to move up, and that’s one of the reasons the manufacturers have made the higher doses such a large price increase, very few people should need them, many people, myself included, rushed up the doses as we thought we should and we could. In reality we could have stayed at a Lower dose and still lost the weight.

So I also went up to 15mg, I was prediabetic and insulin resistance, lost 3.5 stones, as soon as I hit bmi 25 it's like all the suppression was super strong, that's as soon as I started 15mg, I went up because 12.5 wore off and I was hungry all the time and snacking, the hunger was ravenous and I was craving carbs all the time, so I definitely went up when it was needed. I stayed on 2 pens each of 7, 10, 12.5 even though they wore off after 7-8 weeks each, yes even satiety.
I think when I got to a normal bmi my high blood sugars were lowered as all my symptoms were resolved, so then was like a normal person and didn't need the super high insulin, in fact I was often getting low blood sugar symptoms and I didn't crave carbs at all, just healthy food.
Going down from a high dose, well it stays in your system a while, even with a half life and then topping it up. I'm down to 2 weeks x 7.5mg but my carbs have increased and snacking too and i still want to lose half a stone to get to 9 stones before i fully come off, so friday night gave myself what was left of my pen which was 8.75mg and its kicked in all the super high suppression again and ive only had a coffee all day so far and its almost 3pm.
You may find doses are too high, until you find the sweet goldilocks dose, mine appears to be around 8.5mg for all week suppression but i could have easily stayed on 7.5mg and dropped further if i didnt want to lose more and just been more strict with my food choices!

I’m in the same boat. Am 2 pounds away from 10 stone lost. Been on MJ for a year and a half. Briefly went up to 10mg but was too strong. Have lost most of the weight on 7.5 and 5mg. I’m finding 5mg more than enough suppression and still losing but at a slower rate. Think now am almost half my original weight my body doesn’t need as much of a dose to feel strong suppression. Could it be linked to how much we actually weigh at the time too ?

You may think so but how does that explain women weighing 20+ stones staying on 2.5-5mg for their whole journey and myself starting at 13st needing upto 12.5mg. I was prediabetic though. Its more to do with your body producing insulin and how it works including GI system and ongoing inflammation and disease etc

Actually that makes sense, I think you’ve got something there, I went up to ten, and I’m fairly sure I could have went higher. I had increased cortisol and insulin resistance so logically if that’s resolved I need less as I don’t have fhe insulin resistance and cortisol issues any more. But I guess it doesn’t explain why I was on ten and slow losing at the end, but now down to 5mg and finding it just as strong when my weight has basically been the same on 10, 7,5 and 5,

Yes, here is says we get more insulin sensitivity as we lose weight, I suppose this is why. Makes sense

https://www.healthline.com/nutrition/improve-insulin-sensitivity#5-Eat-health-promoting-foods

I’m feeling this too. Have been on 7.5 since March iirc and now at BMI 24 have at least as much suppression and more side effects.

It may be that although sensitivity varies a great deal between individuals unrelated to their weight, for an individual weight change does affect sensitivity?

@Thebigonesgetaway , please can you direct me to where you have seen that one of the reasons the manufacturer has increased prices is to discourage use of the higher doses? I was under the impression that it was to have more equal prices to the US market at Trump’s behest.

i think you need to read the whole thing, I specifically wrote there is two things I think. This means it is my opinion, not a fact.

“secondly we didn’t need to move up, and that’s one of the reasons the manufacturers have made the higher doses such a large price increase, very few people should need them,”
Stated as a fact but just your opinion? Ah, ok.
My understanding was that the manufacturer always intended people to move up through the doses to the highest dose they could tolerate. People react very personally to any medication and many people need to get to the higher doses before they experience meaningful weight loss. My understanding is that the manufacturer is now looking at producing even higher doses for those who may need them.
There is a lot of misinformation about these drugs which is quite unhelpful for those who may be struggling on them.

Good grief, really,

”i have two things that I think now”

firstly and secondly, then detailed. It doesn’t even need a lot of reading comprehension.

Drug companies are all about the profits , there is no way the put the prices up to discourage higher dose usage .

The clinical trials showed that the higher the dose, the greater the percentage of original body weight lost. So the instructions say to increase the dose if your weight loss has stalled (or your prescriber will).

I’m not sure,they out of stocked repeatedly on the high doses so don’t have the capacity, the 12.5 and 15s were often unavailable, and factually the price is so high for those doses people will think much more carefully before going up to them, and will try to avoid in a lot of cases.