I'm just catching up on New Scientist publications, so forgive me if you have seen this already. This is from a September publication re Wegovy.
Some research has been done about effectiveness Vs side effects of increasing doses in Wegovy. there were 3 groups, those on the normal doses, those who went up to increased doses and those on a placebo.
On the whole those on the extra doses lost more, but experienced greater side effects. I thought the following 2 paragraphs were of most interest:
.......But there are drawbacks. While 61 per cent of those on the standard dose experienced gut-related side effects such as nausea, vomiting and diarrhoea, this occurred in 71 per cent of those on a higher dose. Meanwhile, 40 per cent of those on a placebo experienced the same symptoms. That is because people can have such symptoms for reasons unrelated to the treatment, says Heisler.
......Furthermore, more than a fifth of those in the higher dose group experienced unpleasant and painful skin sensations known as dysesthesia. As a result, four participants discontinued the treatment. In contrast, just 6 per cent of those receiving the standard dose and only one person on the placebo had this side effect, none of whom stopped the treatment.