➡️ ☹️ 5th dose being removed from kwikpens

[WeAllHaveWings]

If I am reading this right (will be pleased if anyone can tell me I am not!). There might be further changes meaning the amount of medication in kwikpens is being reduced from 3ml to 2.4ml. No more 5th doses ☹️

Original -

<a class="break-all" href="https://web.archive.org/web/20250501154022/www.medicines.org.uk/emc/product/15484/smpc" rel="nofollow" target="_blank">https://web.archive.org/web/20250501154022/www.medicines.org.uk/emc/product/15484/smpc

6.5 Nature and contents of container
Mounjaro 2.5 mg KwikPen solution for injection in pre‑filled pen
Each pre-filled KwikPen contains 3 ml of solution.
Each pre-filled KwikPen contains 12.5 mg of tirzepatide in 3 ml solution.
Each pre-filled KwikPen contains 2.4 ml of solution that can be administered.
Pack sizes of 1 and 3 pre-filled KwikPens. Not all pack sizes may be marketed.

New -

https://www.medicines.org.uk/emc/product/15484/smpc

6.5 Nature and contents of container
Mounjaro 2.5 mg KwikPen solution for injection in pre‑filled pen
Each pre-filled KwikPen contains 10 mg of tirzepatide in 2.4 ml solution.
Pack sizes of 1 and 3 pre-filled KwikPens. Not all pack sizes may be marketed.

Doesn't read like a change to me - it says they contain 3mls, of which 2.4mls can be administered (ie the 4 doses that then pen allows to be delivered).

Are you being obtuse? It is a change, a significant one, for those who were using the remaining liquid. Whether you agreed with, or did that yourself is irrelevant.

I really think you've taken her post wrong. In no way did I read it as her being obtuse!

Wow, that's a bit rude! You said you'd be pleased if anyone could tell you that you were reading it wrong. I simply said that I read it differently to you - I read it as saying that the pens contain 3mls (as they do currently) of which 2.4mls can be administered through the proper mechanism of the pen (like now). The extra 0.6mls is not intended to be administered, which is why we have to use alternative means to get it out. I don't see anything in what you quoted to say there is a change (and I do currently use the extra dose so would also be impacted by a change).

Apologies to @RenegadeKeeblerElf if I have taken it wrong.

It reads to me that the pens originally had 3ml and now only have 2.4ml. Which means less medication in the pen and no 5th dose (whether allowed or not)

I do see what you're saying, I think it's just a change in how they are wording it. We'll just have to wait and see.

Apologies again.

The new information says -

Each pre-filled KwikPen contains 10 mg of tirzepatide in 2.4 ml solution.

so it no longer contains 12.5mg in 3ml of solution.

Yes, it looks that way. They are not mentioning any extra content, so it might not be there.

Yeah, I do see how that is different, but it may just be a change in the wording.

This was always going to happen. I don’t think they lose much £ or care about the extra liquid itself, but they will be realising the scale and impact on total orders made. If you didn’t use it you need 13 pens a year. If you use it you need less than 11 pens a year. What it won’t prevent is sub-dosing with clicks, however tightening up monitoring of order histories could do that in future.

Original

Each pre-filled KwikPen contains 12.5 mg of tirzepatide in 3 ml solution.

New

Each pre-filled KwikPen contains 10 mg of tirzepatide in 2.4 ml solution.

Sounds more than change of wording.

Yes, it’s the same concentration, minus 0.6ml which was the ‘extra dose’ still leaving plenty for priming as there was always enough plus spare over and above 0.6ml.

Same pen, but reduced filling

I see what you’re saying OP, and agree it could well be a real change. The previous particulars very clearly state the 3ml total, the new one states 2.4ml total. So if they’ve managed to rework the pens to deliver four doses reliably without extra volume we may well be about to lose the bonus dose. It’s a shame, but was kind of inevitable.

Yes, your updates does confirm it. On top of the price rise it’s a double whammy.

Looking at the information in the OP, there has clearly been a change in the amount in a pen removing our golden dose. I expect this will filter through in the new pens in the next couple of months or so. I was already thinking of moving to wegovy so I think this makes that decision even easier.

Discussed extensively on Reddit yesterday (presumably OP that's where you found the evidence) but yes all evidence points to the 4th dose being removed.https://www.reddit.com/r/UKMounjaro/s/1ETiszdWAW

This is the larger document behind the SPC - so yes, unfortunately

Get ready for the stock piling of 3ml filled pens while they are still available, even at the new prices in September. The problem being we won't know when they will change 🙈

Eli Lily have already changed pen designed once to get rid of the hard twist method of getting a fifth dose so it is not surprising if the reduce the volume of priming liquid so a full fifth dose is not feasible.

So we MJ users are going to get a double whammy with higher prices and no fifth dose. It will leave many priced out of MJ.

I've heard this on Reddit. So it's in a way making the price even higher as the price is now only for 4 doses not 5 🙄 I'll still be sticking with mj as long as I can though as it's been life changing

Yes @Pumpkinforever , not surprising, but will still be an extra worry for many.

Ideas to continue to spread the cost over 5 weeks - maybe instead of -

4 x 2.5mg, take 5 x 2.0mg
4 x 5.0mg, take 5 x 4.0mg
4 x 7.5mg, take 5 x 6.0mg
4 x 10mg, take 5 x 8mg
4 x 12.5mg, take 5 x 10mg
4 x 15mg, take 5 x 12mg

Or take full doses every 9-10 days (days 0,9,18,27) instead of every 7....would spread a pen over 5 weeks.

Obviously reduces the concentration in body, but might not be too noticeable for some especially at lower doses whether the difference is not as significant.

Hopefully they haven't changed the click mechanism and syringes 💉will no longer be needed as it will all be within the click allowance.

Fortunately for me I receive the maximum benefits on 5ml, which means I can get 3 months' worth out of a 15ml dose pen.

That doesn't sound very safe, having it open for so long and repeatedly perforated with needles. Even if the needle is sterile inside the packaging, one mistake in manipulation and it isn't sterile any more, and it will give any contamination months to grow.

Oh no, that’s really disappointing news on top of the price rises. I wonder how soon we will start to see this?