Page 2 | Mounjaro seems to be getting less and less effective…

Spookygoose · 2025-08-22T10:16:43+00:00

This is my 4th month on MJ. I had good suppression on 2.5 for the first month and lost quite a lot so I ordered another 2.5 for the second month. However towards the end of that my appetite was coming back so I went up to 5. I didn’t notice much difference so for this 4th month I’ve gone up to 7.5 but it doesn’t seem to be making any difference. My appetite isn’t anymore suppressed, in fact it’s coming back even more strongly. Has it just stopped working?! I feel no difference on 7.5 than I did at 2.5. Anyone else found this? Did going up to 10 make any difference? I only had mild side effects in the first month, don’t have any now

Thebigonesgetaway · 23/08/2025 15:16

anitarielleliphe · 23/08/2025 15:03

I did not mean to offend, and certainly did not mean to sound like I was lecturing you.

I have had a very personal experience with these meds that hurt someone I love. Like with most medications, many people have no issues, but a select few do, so all-in-all, it feels like they have been good for most people. And when it comes to diabetic patients, or those with heart disease, obviously any risk is outweighed by the help in managing those diseases, and lessening the risks associated with them.

It's just for the select few that do not have a good experience with the medication it can be devastating. If you need them, great, but as I've read often on this site there are many people who do not qualify in the obese category so they are fudging numbers to get them (again, not saying this is you), and there is a blanket acceptance that there are no issues with doing that since people see immediate results. Again, anyone with connections to the pharmaceutical industry, which I have, knows that drug trials are often flawed, and not thorough, and sample a very small population, for a specific use. It is later that more data comes to light and revisions to risks are made.

Examples of what I mean by this are Vioxx and Ciprofloxin.

My personal feelings, and I believe I am entitled to my opinion without being attacked, are that the off-label usage of weight-loss only got approved two years ago, and that in the lifecycle of drug development, testing and approval, this is a short-span of time, so anyone willing to use just needs to be hyper-aware of potential risks.

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Are you maybe looking at the uk only approvals and not the global ones? Or what the active ingredients have been used for over the last few decades? You seem to have a very narrow social media led view it seems,

anitarielleliphe · 23/08/2025 15:47

Thebigonesgetaway · 23/08/2025 15:16

Are you maybe looking at the uk only approvals and not the global ones? Or what the active ingredients have been used for over the last few decades? You seem to have a very narrow social media led view it seems,

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I do not use social media, except Mumsnet. My data comes from personal experience and research with peer-reviewed studies and medical articles.

anitarielleliphe · 23/08/2025 15:49

Thebigonesgetaway · 23/08/2025 15:16

Are you maybe looking at the uk only approvals and not the global ones? Or what the active ingredients have been used for over the last few decades? You seem to have a very narrow social media led view it seems,

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I also do not have a favorable view of USA FDA approvals, as they have been very wrong on expediated approvals in the past.

WeAllHaveWings · 23/08/2025 16:00

as I've read often on this site there are many people who do not qualify in the obese category so they are fudging numbers to get them (again, not saying this is you), and there is a blanket acceptance that there are no issues with doing that since people see immediate results.

@anitarielleliphe There is no "blanket acceptance" for ineligible posters attempting to fudge numbers. Any of those threads are very divided and ime are weighted more towards the poster being warned about the risk balance. Sometimes MN will remove the posts if they are reported and breach site guidelines - which trying to obtain POM illegally does.

It is not appropriate to bring your "lecture", an inaccurate one at that, onto and derailing the thread of a poster who is eligible for this medication, asking for support. If you want to discuss your perceived risks with this medication start your own thread.

FoxRedPuppy · 23/08/2025 16:00

anitarielleliphe · 23/08/2025 15:03

I did not mean to offend, and certainly did not mean to sound like I was lecturing you.

I have had a very personal experience with these meds that hurt someone I love. Like with most medications, many people have no issues, but a select few do, so all-in-all, it feels like they have been good for most people. And when it comes to diabetic patients, or those with heart disease, obviously any risk is outweighed by the help in managing those diseases, and lessening the risks associated with them.

It's just for the select few that do not have a good experience with the medication it can be devastating. If you need them, great, but as I've read often on this site there are many people who do not qualify in the obese category so they are fudging numbers to get them (again, not saying this is you), and there is a blanket acceptance that there are no issues with doing that since people see immediate results. Again, anyone with connections to the pharmaceutical industry, which I have, knows that drug trials are often flawed, and not thorough, and sample a very small population, for a specific use. It is later that more data comes to light and revisions to risks are made.

Examples of what I mean by this are Vioxx and Ciprofloxin.

My personal feelings, and I believe I am entitled to my opinion without being attacked, are that the off-label usage of weight-loss only got approved two years ago, and that in the lifecycle of drug development, testing and approval, this is a short-span of time, so anyone willing to use just needs to be hyper-aware of potential risks.

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One person’s personal experience isn’t science though. It’s anecdata. Far better to look across all the studies. And yes, some people will have adverse reactions, like any drug. Life is about risk assessment.

And as previously stated gallbladder issues and pancreatitis are both impacts of weight loss, regardless of how you lose it.

you entitled to an opinion if it is based on fact, but your posts came across as scaremongers.

anitarielleliphe · 23/08/2025 16:11

WeAllHaveWings · 23/08/2025 16:00

as I've read often on this site there are many people who do not qualify in the obese category so they are fudging numbers to get them (again, not saying this is you), and there is a blanket acceptance that there are no issues with doing that since people see immediate results.

@anitarielleliphe There is no "blanket acceptance" for ineligible posters attempting to fudge numbers. Any of those threads are very divided and ime are weighted more towards the poster being warned about the risk balance. Sometimes MN will remove the posts if they are reported and breach site guidelines - which trying to obtain POM illegally does.

It is not appropriate to bring your "lecture", an inaccurate one at that, onto and derailing the thread of a poster who is eligible for this medication, asking for support. If you want to discuss your perceived risks with this medication start your own thread.

This thread which I was a part of months ago shows what I am speaking of if you read further down . . . various people suggesting editing photos and fudging weight numbers to get the meds.

https://www.mumsnet.com/talk/weight-loss-injections/5368535-injections-when-not-seriously-overweightobese?reply=145501580

So, like I was saying, not trying to be a fear-monger, but what I see a lot of with people (in general) when it comes to most medications is a blanket acceptance that if it has passed drug-testing and is approved and people are seeing results, there is nothing wrong, to the point that people will fudge numbers and what-not to get them when technically they are not really in the demographic approved for its use.

As I mentioned, then what happens later, oftentimes, and I am not saying it will with these drugs, is more people using the drugs results in more data, and then revised risk numbers and warnings.

Injections when not seriously overweight/obese | Mumsnet

I’m a bit overweight…BMI around 26.5. Late 40s. I do have high blood pressure (genetic - both parents had heart attacks) and my mother also had type 2...

https://www.mumsnet.com/talk/weight-loss-injections/5368535-injections-when-not-seriously-overweightobese?reply=145501580

FoxRedPuppy · 23/08/2025 16:14

People take lots of drugs inappropriately. That has no bearing on the data, because they aren’t using it as it was intended.

That’s like using use of heroine to measure how effective morphine is.

anitarielleliphe · 23/08/2025 16:18

FoxRedPuppy · 23/08/2025 16:14

People take lots of drugs inappropriately. That has no bearing on the data, because they aren’t using it as it was intended.

That’s like using use of heroine to measure how effective morphine is.

Except for the fact that we are not talking about "two" different drugs, but the same drug used by people that have different weights/BMIs/

Horserider5678 · 23/08/2025 16:22

SilenceInside · 22/08/2025 14:10

@anitarielleliphe what on earth are you on about?? Each time the OP asks for a new prescription for a specific dose it is reviewed along with her medical history before being approved. It's totally inappropriate to advise her to stop taking it!

Mounjaro is not used "off-label" for weight loss, it is fully approved for weight loss by the MHRA and has been for a good long while.

Muscle loss and issues with bone density are related to any weight loss programme, and are easily mitigated by exercise and good nutrition. This is not new information for someone who has been legitimately prescribed Mounjaro for weight loss.

Not every one is getting them with medical support! Many are buying from unreputable sources such as TicToc! What poster is asking is OP being reviewed before increasing her dose! You are really naive if you think everyone gets medical advice!

anitarielleliphe · 23/08/2025 16:31

Horserider5678 · 23/08/2025 16:22

Not every one is getting them with medical support! Many are buying from unreputable sources such as TicToc! What poster is asking is OP being reviewed before increasing her dose! You are really naive if you think everyone gets medical advice!

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Yes, that was it. I was just hoping that she was dosing under medical guidance and was aware of the risks. I was not judging her on her desire to lose weight or her methods if she was doing it under a physician's guidance and not supplementing from other sources . . . which I have seen people do if their physician will not up their dose.

I feel badly that my questions were perceived as fear-mongering and attacking her. That was not the intent at all.

PinkArt · 23/08/2025 16:39

anitarielleliphe · 23/08/2025 15:03

I did not mean to offend, and certainly did not mean to sound like I was lecturing you.

I have had a very personal experience with these meds that hurt someone I love. Like with most medications, many people have no issues, but a select few do, so all-in-all, it feels like they have been good for most people. And when it comes to diabetic patients, or those with heart disease, obviously any risk is outweighed by the help in managing those diseases, and lessening the risks associated with them.

It's just for the select few that do not have a good experience with the medication it can be devastating. If you need them, great, but as I've read often on this site there are many people who do not qualify in the obese category so they are fudging numbers to get them (again, not saying this is you), and there is a blanket acceptance that there are no issues with doing that since people see immediate results. Again, anyone with connections to the pharmaceutical industry, which I have, knows that drug trials are often flawed, and not thorough, and sample a very small population, for a specific use. It is later that more data comes to light and revisions to risks are made.

Examples of what I mean by this are Vioxx and Ciprofloxin.

My personal feelings, and I believe I am entitled to my opinion without being attacked, are that the off-label usage of weight-loss only got approved two years ago, and that in the lifecycle of drug development, testing and approval, this is a short-span of time, so anyone willing to use just needs to be hyper-aware of potential risks.

Show quote history

Siri, what's a word to describe mansplaining but it's explaining the risks, side effects, research of WLI to people who are fully informed users of WLI, by people who aren't using WLI themselves?
No-one seemed concerned about the potential side effects when it was just diabetics they were prescribed to. No-one seems concerned about them for future cancer, heart, dementia, addiction patients. Just the fatties who've been prescribed it for the disease of obesity - is it because people think we're all stupid so can't possibly have risk assessed?

WeAllHaveWings · 23/08/2025 16:51

@Spookygoose sorry your thread has gone tits up. You might be better starting another, if you still need support, as this one is now under the expert guidance of the Senior Vice President of Weight Loss Doom 🙈

GLP1Girl · 23/08/2025 16:58

WeAllHaveWings · 23/08/2025 16:51

@Spookygoose sorry your thread has gone tits up. You might be better starting another, if you still need support, as this one is now under the expert guidance of the Senior Vice President of Weight Loss Doom 🙈

🤣

anitarielleliphe · 23/08/2025 17:01

PinkArt · 23/08/2025 16:39

Siri, what's a word to describe mansplaining but it's explaining the risks, side effects, research of WLI to people who are fully informed users of WLI, by people who aren't using WLI themselves?
No-one seemed concerned about the potential side effects when it was just diabetics they were prescribed to. No-one seems concerned about them for future cancer, heart, dementia, addiction patients. Just the fatties who've been prescribed it for the disease of obesity - is it because people think we're all stupid so can't possibly have risk assessed?

Show quote history

If that is how you walk through life . . . coming to that type of negative interpretation on another person's character . . . I am really sorry that someone or so many people hurt you so profoundly. Again, your interpretation of my intent is just wrong, and given you are not the only one, it has made me realize that many people using this drug for weight-loss have some sort of internalized fear of judgment. You should not, and again, that was not my intent.

anitarielleliphe · 23/08/2025 17:02

GLP1Girl · 23/08/2025 16:58

🤣

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I fully give this thread back, and will not be posting anymore. --Sincerely, Senior Vice-President of Weight Loss Doom, as interpreted by others

FoxRedPuppy · 23/08/2025 17:07

anitarielleliphe · 23/08/2025 17:01

If that is how you walk through life . . . coming to that type of negative interpretation on another person's character . . . I am really sorry that someone or so many people hurt you so profoundly. Again, your interpretation of my intent is just wrong, and given you are not the only one, it has made me realize that many people using this drug for weight-loss have some sort of internalized fear of judgment. You should not, and again, that was not my intent.

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It why just this thread? Have you copied and pasted onto the other 75 threads on the WLI board? It was so weird and out of sync with the question the OP asked.

Also heroine and morphine are essentially the same drug.

FoxRedPuppy · 23/08/2025 17:07

WeAllHaveWings · 23/08/2025 16:51

@Spookygoose sorry your thread has gone tits up. You might be better starting another, if you still need support, as this one is now under the expert guidance of the Senior Vice President of Weight Loss Doom 🙈

😂😂😂😁

HansHolbein · 23/08/2025 17:12

What is it with these fuckwits wondering in on the WLI section giving their unsolicited opinion on things they have no personal experience of?!

hAvE yOu DoNe YoUr ReSeArCh BeCaUsE yOuRe GoInG tO dIe 🫠

Mounjaro seems to be getting less and less effective…

PinkArt · 23/08/2025 17:24

anitarielleliphe · 23/08/2025 17:01

If that is how you walk through life . . . coming to that type of negative interpretation on another person's character . . . I am really sorry that someone or so many people hurt you so profoundly. Again, your interpretation of my intent is just wrong, and given you are not the only one, it has made me realize that many people using this drug for weight-loss have some sort of internalized fear of judgment. You should not, and again, that was not my intent.

Show quote history

LOL. Oh pipe down 😂
You came here with your ill-informed opinions, for whatever bizarre reason, and people have called you out on your nonsense. @Spookygoose is planning on using mounjaro exactly as it's licensed, with increased doses each month, for a disease it's licensed for. And she's getting it prescribed, as most of us are, by a doctor at an online pharmacy.
There was nothing in her post that suggested she needed a lecture from anyone, especially someone who doesn't even know that semaglutide and tirzepatide are different medications. You though, for some reason, thought that was the best thing to do.
You are the WLI equivalent of men mansplaining periods to women.

Scarlettpixie · 23/08/2025 17:33

anitarielleliphe · 23/08/2025 16:31

Yes, that was it. I was just hoping that she was dosing under medical guidance and was aware of the risks. I was not judging her on her desire to lose weight or her methods if she was doing it under a physician's guidance and not supplementing from other sources . . . which I have seen people do if their physician will not up their dose.

I feel badly that my questions were perceived as fear-mongering and attacking her. That was not the intent at all.

Show quote history

I have been on these boards and other forums and taking MJ since October. I have never seen anyone say that their physician refused to up their dose if they are taking MJ for weightloss. The manufacturers guidelines were that you move up each month but with use and experience it has been found that many people have great success by staying on the lower doses for longer. The general rule is if it is still working you can stay on your current dose and when it becomes less effecive you can move up (depending ont the severity of any side effects you may experience).

mollibu · 23/08/2025 17:36

2.5 for me - like injecting water
5 for me - injecting water in terms of how much I could eat but no urge to snack in between meals
7.5 for me is when I first started to notice a difference but my appetite was still there
10 now and my favourite dose so far, I would recommend buying 10mg next!

ForHonestTiger · 23/08/2025 19:45

Are you drinking enough, doing any exercise and eating in a calorie deficit? Its supposed to be used alongside all those things. I have been on 2.5 for 25 weeks and have lost 3 stone, but I've have to work hard at the above.

PearlsPearl · 23/08/2025 20:18

HansHolbein · 23/08/2025 17:12

What is it with these fuckwits wondering in on the WLI section giving their unsolicited opinion on things they have no personal experience of?!

hAvE yOu DoNe YoUr ReSeArCh BeCaUsE yOuRe GoInG tO dIe 🫠

YES love this! Weird spate of 'JUST EAT LESS AND MOVE MORE' and 'WLI WILL KILL YOU' trolls recently.

Burnserns · 23/08/2025 20:42

You have to wonder if some people come on a thread and think, "now how to I make this other's person's thread all about me...."

Burnserns · 23/08/2025 20:47

Op on a serious note, I would say don't judge a dose's effectiveness by suppression, judge it by satiety. Do you feel full after eating a balanced meal and stay full for longer, and are you losing 0.5-1% of your body weight a week (averaged over 4 weeks)? Then the dose is doing it's thing.

Suppression IME comes and goes and often doesn't last when you've been on a dose a while, if you're chasing suppression you might find yourself climbing the doses quickly.