Can I expect much better suppression on 15mg?

[JMSA]

I’m on 12.5. Interestingly, I haven’t noticed much of a difference between the doses, from 7.5 and upwards.
I’m still relying on willpower, obviously eating at a calorie deficit and making good choices. Things are stagnating and I haven’t lost any weight in a month. I haven’t put on any either, which is a plus, but it’s too expensive for that!
No regrets, Mounjaro has been good. But I’m starting to feel a bit disheartened.
Everyone is affected differently, I get that, but is it likely that things will start moving on 15mg? I still feel hungry a fair bit and would absolutely not struggle to eat a big meal.

I think no one can tell you you need to try it. If you’ve been moving up each month, not felt anything, relying on will power and can eat a big meal, I’d say you’re maybe someone who it doesn’t work for and the early doses were a placebo effect, but maybe not, if you’ve finished your 4 weeks on 12.5 then I’d give it a shot. If you’ve been maybe staying on lower doses too long ie doing multiple pens, then anecdotally those folks can often struggle, the body acclimatises quite quickly. Good luck.

Thanks for your reply! I’ve been moving up each month. I’ve never settled on the same pen twice.
7.5 was as effective for me as 10 or 12.5. So fairly good but not absolute suppression.

@JMSA how much have you lost?
I moved up each month, didn’t have much suppression from 7.5mg. I do feel a bit better suppression on 15mg. I’m going to keep going - I know I’d have given up by now without it and be gaining. I’ve lost on average 1lb a week (I did have a holiday though where I put on 5lbs so that set me back a bit).

I’m week 3 of 15mg and feel more suppression than on week 1 and 2.

That’s good to hear!
Ive actually done not too badly. I’ve lost a good couple of stone. But it seems to have plateaued a bit now.
I’ll definitely keep going. I guess losing it slowly means you can sustain it a bit better.
I’ve lost 4 stone before (way before Mounjaro) and piled back on every lb and more, so I live in fear of that happening again!

Good luck to all of you.

It should never be absolute suppression, but there is a huge difference between absolute suppression and can eat a big meal. So I’m struggling with where you are, as you start off saying you’re relying on will power and can eat a big meal but then say it’s pretty good just not absolute. I’d say you’re on too low a dose if you can easily eat a big meal, but if you’re aiming for absolute suppression and it’s pretty good, then you’re on the right one, it is not really feasible for us to say which it is as you’ve said you’re both.

What is your TDEE?
How many calories a day are you eating?
What does a typical day of food look like?
Are you getting enough sleep, or are you more stressed than usual?
Are you drinking enough water?

All the above will contribute to your appetite level and your weight loss success even with Mounjaro supplementing you.

I guess I mean good in relative terms, like better than it would be if I wasn’t on Mounjaro at all! It does help a lot with food noise and curbing cravings of chocolate, etc. But the suppression could be better.

I am for around 1300 calories a day. I know my body and any more than that, I would struggle to lose at all. In fact, my best losses come when I eat less, but the lack of suppression can make that difficult.
I will admit that I am very poor at drinking enough water. It’s a real failing of mine.

So I'm similar to you, doses wore off quickly, I have been prediabetic for years and didn't know. I'm 5 weeks in on 15mg and struggled everyday to eat over that time as it gave me super strong suppression even though 12.5mg wore off and I was getting cravings amd ravenous hunger again.
I'm just so glad I've finished this pen so I can drop down to 12.5mg so i can eat. I am at bmi 24.2 so I'm not bothered about staying at the top anymore. I managed 930 cals yesterday and so far today 350 cals and its 6pm! I do jab on Friday night so its the strongest right now and I did the bonus dose so probably got 17mg, not great! Luckily I've not suffered any GI side effects, just very tired throughout.

@Mysticmaiden
That’s really interesting - thanks for your perspective. Tiredness has been a thing for me too.
If you don’t mind me asking, how was it brought to your attention that you were pre-diabetic?
I can’t imagine being so fully suppressed that I don’t want to eat, but let’s see!

I had my nhs health check at 40 in june 2022 and was told everything was OK, just low in haemoglobin and raised BP, so take iron and try to eat healthier and exercise etc I then changed GPs almost 3 months ago now and they updated my nhs app and GP app where I saw all the results. My HBA1C was 45, 48 and above is diagnosed as diabetic. I also had other abnormal tests like top of the range of plasma glucose and abnormal liver test and 12.5% hyperchromic cells, which should be below 5% and indicates anaemia.
Mounjaro does interfere with dopamine pathway which leads to tiredness and low energy, though it could be the low calories too. Eating a higher protein diet and low carb has been a life changer for me. A lot of western population are insulin resistant and not aware, carb cravings is a big sign of insulin resistance and prediabetes and thats all i wanted to and used to eat, especially as i didn't eat meat for 5 years. I have overhauled my diet on mounjaro so hoping I have reversed my insulin issues, it was 10mg that resolved my unstable blood sugar symptoms of feeling dizzy, shaking hands and having extreme hunger and mood swings if I didn't eat regularly, also unable to fast due to feeling light headed etc. Now I'm fine not eating for ages, didn't eat until 4pm today.

I've found suppression on 15 mg good so far. Better than previous doses (10 mg/12.5 mg) - early days though (only taken 5 doses so far but suppression still good). I did sub dose my way up though. Had bad side effects around 4.5 mg and so was probably a bit too cautious going up, but picked up the pace at the end as really wanted to get decent suppression back.

Graph is the doses I have taken so far (need to click on it for full picture, last 4 doses of 15 mg & Y axis labels missed off on preview).