Less effective since changing suppllier

[Bati]

I am getting close to my goal weight.
2 months ago I changed suppliers from chemist 4u to Oushk as I would like to do a maintenance dose once I achieve my goal.
When I change I was on 6.25 dose (50 clicks) this had been working really well for me - I noticed the first pen with new supplier wasn't working as well so I thought I needed to move up so next pen I would do the full dose 7.5
Well the 7.5 is no better than the 6.25 - I have done a full pen on it now.

The effects used to be really strong for 48 hours after injecting and then gradually lesson through the week.
Now I am feeling hungry a lot and snacking is creeping in - I have maintained my weight but not lost any.

Could it be my body is now used to mounjaro and even though I increased my dose it won't have an effect on me now and moving up to 7.5 wasn't enough and I need to go to 10.

Or could the 2 different chemist's get their mounjaro from different suppliers and have slightly different ingredients - meaning it has different results for me.

Wondering if I should go back to my original supplier x

Mounjaro is a registered trademark so every legitimate supplier will have the exact same medication from them. It maybe that your body has just got used to the medication. Have you recalculated your calorie intake?

I have never calorie counted on it, just eaten less and more healthy.
6.25 worked really well for a few months, then I changed chemist's and it didn't work as well so I moved up to 7.5, this was 4 weeks ago and it's had less effect than any other dose x

It’s only made by one company, so it’s just a coincidence that your changes have been at the same time as moving supplier, I’d recalculate your calories with your current weight, you might just be having a plateau, maybe move up to 10 if you’ve not got enough suppression and are snacking.

As long as you're getting it from a registered supplier it's a coincidence. If you're getting very hungry it's worth going up but hunger is normal so I wouldn't try to repress it too much.

You need to go back to basics and calculate your calorie requirements and then what you need to eat to achieve an adequate deficit to lose the required weight. It's really worth calculating this and food logging for a few weeks at least as it may be less than you imagine. As you lose weight your calorie requirements go down so you can't rely on standing still, you need to reduce further.

It may just be that you are close to goal, so losing slows down and gets harder. Also, many people find they need to increase their dose after a long time on the same one, especially as you are on a fairly low dose.

ETA. I've not calorie counted at all either. I'm at goal now (BMI 20.8) having lost 100lb in a year.

Mounjaro is only made by one company so all of the (legal, registered) suppliers sell exactly the same medication.

Your body can react differently to doses and will become accustomed to certain levels over time. You may find that the 7.5 becomes more effective over time (or even less!) and you will need to move up. That is why there are different doses and a titration programme.

I've been with Oushk since January, never had an issue with delivery on nominated day and always arrives cold. It has been warmer lately with many days reaching over 30.C which is the max room temp, have you been storing your fridge in pen and if not are you using it within 30 days?

It is more likely to be tolerance, I've never managed to stay more than 2 pens on a dose, with most wearing off way before then due to having prediabetes. Actually 2.5mg and 7.5mg were the least effective pens for me. Also 6.25 and 7.5mg are really close together so there won't be a noticeable difference between the two. Why don't you go up to 10mg and use it as it is, especially if you have not had any side effects. I don't understand why you were doing a smaller dose.
I'm on 15mg now 2nd week in which is working beautifully. Also other factors may affect suppression and hunger like stress, poor sleep and hormones.

Yes I keep it in the fridge

I did have side effects, so when I went from 5mg to a 7.5mg, I decided to do 6.25mg to try and combat the effects.

I currently don't have any side effects now but my suppression is also a lot less - the 6.25mg worked well for a couple of months but then was less effective so I moved up to 7.5mg 4 weeks ago.

Normally when I move up I can telI I am on a stronger dose but the 7.5mg is the least effective of all so far and no side effects at all.
I will order the 10mg - just not sure if I should jump up to the 10mg or maybe do 8.75mg - don't want any nasty side effects x

Seriously I wouldn't mess with the doses unless you have to. If you don't feel any suppression on 7.5mg and don't have any side effects then an extra 1.25mg will be unlikely to work and again wasting time and doses and have to rely on will power.
Go up to 10mg and see how you get on.

When I started, 2.5mg only lasted 2 weeks and I had zero side effects, I did the rest on will power, yet I was too frightened to go up to 5mg because of all the side effects posts on social media, so I went up to 3.75mg first and was still starving and regretted it, i topped up 1.25mg after 4 days, which helped a little. 5mg was strong initially but only lasted 5 weeks for me, I then again went up to 6 and 7.125 but they only lasted a few days before 7.5mg which again was strong with nausea initially. It was all a waste of time as I had to rely on will power for months mostly. It was actually 10mg almost 5 months into my journey that finally worked well and resolved my high blood sugar symptoms and my carb cravings.

@Mysticmaiden In fairness, that's your experience, as someone who doesn't seem to respond so well to the lower doses. For those of us that do respond very well, we are likely to get side effects or too strong suppression if we move up 2.5mg at a time. I am about 22 weeks in and still on 5mg. I slowly went up to 3.75mg over several doses, but jumped straight to 5mg from 3.75 (which I did for 5 weeks). None have ever been a wasted dose. Should I feel the need to go up in the future there is no way I would leap up to 7.5mg, that's asking for trouble. However, that's fine for people who it doesn't have such a strong effect on.

However, it does sound like OP need to move up a dose. I suspect that as you move through the higher doses, the relative increase as a percentage is much less, removing the need for a stepped increase for some. Although, the boards are full of people who do have problems moving up, even in the higher ranges, so there does seems to be some merit in moving up slowly/using transition doses.

Could it be my body is now used to mounjaro and even though I increased my dose it won't have an effect on me now and moving up to 7.5 wasn't enough and I need to go to 10.

Yes.

Or could the 2 different chemist's get their mounjaro from different suppliers and have slightly different ingredients - meaning it has different results for me.

No.

Your body is used to it. Hunger is to be expected. Suppression is a side effect not everyone has.

It won't have different ingredients, but I guess if it's not been stored quite right it might lose efficacy. During their recent inspection it was highlighted that Oushk's fridge temperatures may not have been maintained at the correct level, but who knows whether this would have impacted the pens you received, or if that would have been the result anyway. I've had a similar experience though and moved suppliers, at which point things picked up again.

So what I mentioned was sticking to Eli Lillys recommended dosage increases, which was used in clinical trials. In fact in the trials the only doses used were 5, 10 and 15mg and then the half way doses were added after.
No pharmacy will recommend doing split doses and people shouldn't be promoting this as it is against manufacturer recommendation. In fact pharmacies to promote taking a dose less often if strong such as every 9 days.
I have had strong appetite suppression on most doses at the start where i struggled to eat but in a few weeks this reduces due to tolerance and this happens with most people. The best dose is one which keeps you suppressed most of the week.
The fact that OP said they are hungry a lot and snacking and the jump from 6.25 to 7.5mg didn't help and that 7.5mg is the least effective shows that they need a stronger dose.

This isn’t necessarily true. My pharmacy did recommend that I stick to a half dose (3.75mg) due to side effects. When I said I needed to go up, they recommended injecting every 5 days, rather than going up to 5mg. So it’s worth chatting to your provider, especially if you’ve had some bad side effects previously

What I wondering is will 15mg stop working as well. I've noticed a lot less suppression on my final dose of each pen so far. But only 15mg is a full dose.