Mounjaro and under active thyroid

[Sheila321]

Hello lovely helpful people, I would like to start this new thread for advice about using Mounjaro weight loss and also having an under active thyroid, there are a few comments about this topic on mumsnet but not a lot of people contributed, Thank you to the ones that did 👍🏻 I only had my first injection 2.5mg 5 days ago, I would really appreciate it, if people would share their experiences please, I take 125mg Levothyroxine daily, I’m wondering when at the beginning of this treatment people’s appetite maybe started to suppress ( if at all) I’m aware it’s early days for me, I would love to hear your success stories or anything relevant at all please? My main problem is I’m unable to exercise due to disabilities, I’m very sure I am calorie deficit but I’m still very hungry Thank you for taking the time to read this, I appreciate any help, advice I can get TIA

100mg Levo and month 4 . Working well. Marathon not a sprint. Gone slowly and moving 5mg to 7.5mg this time. Weight loss slow and steady. Lost a stone and a half. 5 more to go! Some weeks no loss. Food noise reduced, not eliminated. If I get to bed early, that helps.

Hi 👋🏼 @Sheila321 ive been on Mounjaro since October and have an under active thyroid / I take 150mg daily. I was pre-diabetic and obese in October; I am neither now 😀
for me, suppression started straight away and I’ve never needed to titrate all the way up (maxed out at 10 mg). But for others I know it can take a higher dose to get the full effects. If you follow the dosing schedule, you are likely to start feeling the effects- few people are non-responders.

I’m getting my thyroid checked next week so can report back if it’s changed anything there.

good luck on your journey - and remember to focus on protein, hydration and whatever exercise you can do - walking, housework, seated stretches/arm raises, etc x

Bless your heart for posting 👍🏻 I’m delighted Mounjaro is working for you, please may I ask ( I understand if you don’t want to) how much weight you have lost since October?

I do try to exercise the best I can, I’ve been using “Whey shakes” for protein as I don’t like eating meat, I’m ok with a bit of salmon,

Thank you again for your post and advice

I don’t mind telling anyone - I’m very proud of myself 🤗 - I’ve lost 61 pounds so far and aiming for another 10 to take me to a bmi of around 20

Oh wow 😮 you have really given me hope 👍🏻 Thank you and well done, you should be very proud of yourself, may I ask if your appetite suppressed quickly or was it gradual please?

Thank you for sharing your experience and well done for your weight loss so far 👍🏻

Thank u. My appetite suppression has been intermittent but the food noise stopped very quickly. So sometimes I feel very hungry and others I have to make myself eat (especially on the days I feel nauseous - my most common side effect). But I am never haunted by thoughts of food any more - possibly because I now let myself eat whatever I feel like. And although I do generally focus on healthy protein rich food I don’t deny myself treats - I even ate half a snickers bar yesterday 😂
I would never have believed this weight loss would be possible and in such a short space of time. I’m really excited for you starting your journey @Sheila321 x

Be prepared for your levothyroxine requirements to decrease if you lose a lot of weight. I've gone from 160kg to 74kg and after 40 years of needing 300mcg/day my annual blood test in January showed I was overmedicated.

Current levothyroxine dose now lowered to 200mcg and my hunger levels have dropped significantly, making it much easier to stick to 1400 kcals/day.

Thank you again @JustKeepsBreathing so kind of you to reply to me and tell me about your journey so far 👍🏻 I’ve just been working it out and I think I’m not eating enough, yesterday I had 850 calories so I’ve had a little more today but not much, I’m struggling to drink lots of water, I woukd kill for half a snickers 😂😂😂💐

Thank you @stealthsquirrelnutkin i will ask my doctor for a blood test soon, I’m only 5 days in with Mounjaro so I think I have a few weeks before I need my levels checking, may I ask how long it took you to lose your weight, that is amazing by the way 👍🏻

Underactive Thyroid here. Lost two stone by myself by doing the 800Fast.
Then struggled to keep it up. Have been on MJ for 11 weeks now and lost 1st 3 (I have had a 2 week holiday o it where I eat more). Did 5 weeks on 2.5, then stayed on 5mg. Losing slowly but that is fine. I want to use the drug as a tool rather than relay on it. A little bit of food noise but manageable. Some days I don't fancy much food other days I eat more. I eat much less sweet things and have cut down on drinking - though I do enjoy the off glass of wine. Planning to stick to 5mg for the foreseeable. I like lose another stone and a half.

I’ve lost 65lb on MJ since the end of Nov and 75lb since the end of August, currently 23 BMI. My levo was increased to 100mg earlier this year which has also had an effect on wl.

I immediately felt suppression and the food noise stopped, as I felt queasy for the first two weeks. I’ve had a wl nearly every week since Nov, between 1-5 lb but usually 1-2 lb, stayed the same a few times and put on weight twice and then lost it all the week later. I stayed on 2.5 for three pens, then 5 for quite a long time and eventually moved to 7.5, going no higher and now I’m tapering down and lengthening the times between shots now that I am a healthy weight with a decent cushion that would keep me below BMI 25.

I would say that it’s better to look at wl across a month, rather than week to week. Re side effects, after the initial nausea and some diarrhoea, which could have been a bug, it’s really only been constipation and tiredness. These could also be due to the many other medications I take.

Re exercise, I’ve always gone to the gym regularly and enjoy walking with my family at weekends which we’ve been doing a lot more of.

Thank you for your reply to my post, it’s very helpful to me to know about others experiences, well done on your weight loss @Mangolover123

3 years and five months.

I listened to a Zoe food science podcast back in February 2022 that presented recent research showing that adding 6 small portions of fermented food (kimchi, sauerkraut, kombucha and kefir) to the test subjects diet resulted in a 20% decrease of inflammation markers in their blood at the end of the test period.

I was in agony with rheumatoid arthritis (have a shedload of auto immune conditions including diabetes, hashimoto's, sjogrens, lupus, eczema and asthma), and was willing to try anything to get my joints to stop torturing me, so I ordered a load of jars and bottles of fermented stuff online that same day, and have been eating them every day since.

I still order the kimchi and sauerkraut from Loving Foods UK, but make my own kefir in the instant pot and brew my own kombucha because it's so much cheaper and very easy to do.

To my complete incredulity I lost 10.5kg that first month (while eating what was then my normal diet of between 3500 and 4600 calories/day), 9kgs the second month before it settled down at between 1.5 and 3kg/month over the next couple of years.

I weigh myself every 4 weeks. If the weight loss has been slow for a couple of months in a row I shave another 200 calories off my daily allowance.

Now that I am merely overweight and not obese I've had to lower my calories at closer intervals, but that is compensated for by much shorter intervals between needing to buy a smaller dress size. Before I got fat I measured 36", 28", 36", which used to be a UK size 14. The sizing changed while I was living abroad and last time I checked a 36" bust was a size 12. I'll be 69 in a few weeks time, so I've set my end goal as 67kg (9kg to go) which will give me a BMI of 24.9.

I wish I'd known about the gut microbiome and chronic inflammation levels back in the late 80's when I first started collecting autoimmune conditions and getting fat. For the past 40 years GPs have batted away any health problems with "you just need to lose weight, eat less and move more" and now that I am within a whisker of a normal BMI I'm so old they are going to dismiss any concerns with "what do you expect, at your age?"

@stealthsquirrelnutkin Wow, your experience with fermented foods sounds so interesting. Congrats on your weightloss and general health improvements. When you say 6 portions, do you mean in a week? I sometimes have some kefir but not regularly so maybe I should look into.

@Sheila321 I have an underactive thyroid although it's managed fine by 100mcg thyroxine. I've lost 15lbs in 11 weeks so definitely slower than most and I'm on a 4mg dose. Having said that I started from an overweight position rather than obese and my BMI is currently 26.8 so not too far off a healthy BMI which may explain the slower losses 🤷‍♀️ Hope you've settled into a routine now and are able to eat enough.

@stealthsquirrelnutkin Thankyou for your reply and advice 💐