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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Mounjaro - what actually happens when you stop?

8 replies

Pinkparka · 06/07/2025 18:44

Looking for those that have!
MJ journey is going well for me on 2.5, I’ve not felt the need to move up yet. No SE apart from occasional light head and slight nausea after eating. If i reach my goal weight I would then like to stop and hopefully my new relationship will food will continue as it is - feel confident I can suppress the food noise.
but what actually happens to your body, does the weight come back on instantly? Is it gradual or not at all? I don’t know what I’m picturing but obviously concerned.

OP posts:
DarkForces · 06/07/2025 18:53

Keeping the weight off or not is dependent on your calorie intake vs use. It won't come back on instantly but weight loss injections don't change your metabolism so you'll face the same challenges when you aren't taking it as any other weight loss regime. Most people regain the weight they lost (see the Surpass study). This is why life long/long term maintenance is increasingly available from a range of prescribers. I intend to see where I can reduce it to eg every other month rather than thinking I can come off entirely. I've been on it for 8 months and am on 7.5 so allowed myself space to go up doses if needed. I'm about a stone off my goal weight where I'll be a bmi of 23.

blunderdul · 06/07/2025 18:56

I don’t plan to come off it. 30 years of experience tells me that it is the only thing that’s got me eating properly.

Mounjour · 06/07/2025 20:44

@DarkForces do you mean you’ve done a month on, month off all the way along?

PreciousMomentsHun · 06/07/2025 20:49

My friend works in a diabetes clinic

She is quite pessimistic about it because according to her, all her patients regained the weight the moment they came off the jabs

I'm sure it is not that bad but as with ANY successful weight loss, the hardest part is maintenance

It will mean calculating your TDEE and eating no more than number of calories for the rest of your life

Doable but it may require a lot more awareness of calories and using all the old tricks like drinking water before a meal, never the junk you might binge on in the house, exercising more to help you be in the right place calorically, prioritising protein and veg, etc etc Nothing new and all boring but also not as easy as it sounds.

DarkForces · 06/07/2025 21:04

Mounjour · 06/07/2025 20:44

@DarkForces do you mean you’ve done a month on, month off all the way along?

No. This is what I'd like to do in maintenance I think. I'm still working on it!

India4 · 09/07/2025 12:49

DarkForces · 06/07/2025 18:53

Keeping the weight off or not is dependent on your calorie intake vs use. It won't come back on instantly but weight loss injections don't change your metabolism so you'll face the same challenges when you aren't taking it as any other weight loss regime. Most people regain the weight they lost (see the Surpass study). This is why life long/long term maintenance is increasingly available from a range of prescribers. I intend to see where I can reduce it to eg every other month rather than thinking I can come off entirely. I've been on it for 8 months and am on 7.5 so allowed myself space to go up doses if needed. I'm about a stone off my goal weight where I'll be a bmi of 23.

Thanks for this info…I dread the weight gain.

IReallyNeedThisToWork · 09/07/2025 14:11

I don’t intend to ever find out!!

There are a percentage of people who manage to maintain the majority of the weight loss but for most it does creep back on. Mounjaro is helping with various physiological processes behind the scenes that help with insulin, inflammation etc as well as simply helping you reduce your calorie intake so once that stops, the odds are that you will gain at least some of the weight back.

If you genuinely suffer from a metabolic dysfunction, the medication is likely to be needed for life but if you have generally been a healthy weight and only out some on because of lifestyle changes/trauma etc then you may have greater success at keeping it off. This has NOTHING to do with ‘good habits’!!

Redlightbulb · 09/07/2025 14:41

I would like to come off it eventually due to financial reasons.
I can afford it each month but my frugal nature does not want to be paying out £150 every 5 weeks long term.
Having said that I will likely have to stay on it as with 22 years of dieting so far I haven't been able to maintain a healthy weight.
Mounjaro has really helped with my binge eating.

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