Is anyone VERY sensitive to the jabs?

[Seriestwo]

I’m on monjourno, had 2 x 2.5mg and had zero appetite - I was managing about 700kcsl a day. So I left the 3rd dose til day 10 when I started to feel like I wasn’t still digesting last week’s food. I took a 1.25mg dose this morning and am now nauseous, knackered and have a headache. My plan is to do half dose twice a week - but I’d quite like a moan about the side effects of what is supposed to be a priming dose! I assume this means I will have a good effect, which is great as I have about 5 stones to lose and nothing has ever worked. But, I feel rubbish and I’ve only had a baby dose!

In your position i would just do the half dose weekly and only increase it if/when it stops working. So long as you keep it refrigerated and are careful with swabbing etc it will be fine

I am not so sure.

You can find a 'tribe' of microdosers who all also believe they are especially sensitive blah blah. Many of them decide this even before they start...

HOWEVER this 2.5mg dose is designed for you to get used to the drug, to allow your body to become tolerant and therefore allow the drug to work in the utterly remarkable way that it does which is to increase satiety rather than suppress appetite.

Some people feel nothing on the starting dose and some feel immediately affected. What you describe is fairly common.

So I would say, give it the full month. Learn what the drug does, learn the best way to eat to keep your body nourished and therefore to stop the tiredness and nausea that will come from not eating. Not eating is as much the enemy as binging is...

Learn what you can eat that does not sit in your stomach in the way you describe - perhaps eat a lot more clean protein like chicken/fish and some green vegetables/salad rather than carbs. Find what works for you. You may need to eat many small meals a day to keep your calories up - your side effects can equally be due to not eating enough. And BTW a headache can often be cured by a pint of electrolytes or a pint of water and a salty snack... I am not saying this is definitely the case - I don't know - but that is the thing to try first.

You may find that by the 5th dose you are even ready to go up a dose.

I can only say that I stayed on 2.5mg for 3 months and then stayed on 5mg for the next 5 months. Some weeks I honestly wondered if I had a duff pen as it didn't seem to be working very well and some weeks I had to force myself to eat. It varied ALL THE TIME - something I would never, ever have known if I had been pissing around changing my dose every time something was different. I am now maintaining having lost 5 stone - and bizarrely now finding that although I am making myself eat far more calories AND slowly slowly dropping my dose I am still losing weight. This drug is remarkable - let it work!

Thanks, that’s encouraging, both.

I haven’t come across super sensitive people - thanks, I’ll have a look. I take your point about having too small a dose for effect, but I need to make this sustainable which means eating 1200 calories or so.

I really don’t like vomiting at work, it comes on so quickly and I work in health so puking in the ward loo is not ideal, I’ll get sent home for 48 hours cos thats the rule.

I took 1.25 and thought I’d do it again on Wednesday or Thursday.

I really want it to work, so I’m encouraged by “remarkable drug” comment.

Sorry to hear that you are feeling like that.

Yeah i have been really nauseous after takijg mounhjaro. Its horrible, especially when you are working.

I stayed on 2.5mg for 5 months and lost 3 stone. I never felt the need to move up from the starter dose.

I never felt hungry or fancying treats. Most days I could have probably eaten 200 calories & felt that was enough.

When I would hear about people on 15mg it would seem crazy to me. But maybe like you say I'm just lucky it had an effect on me in small doses.

i just started three days ago and have been vomiting since, about 15 times in total. I have over half my body weight to lose unfortunately doctors advised I stop

Depending on what the side effects are she may not be able to. Eg my doc and 111 advised me to stop

I am one of the crazy ones on 12.5mg soon going upto 15mg! I was prediabetic and insulin resistant so needed a higher dose. Barely felt 2.5mg and it only lasted 2 weeks with minimising food noise and weak suppression. Each dose has not lasted long for me, most wore out after 5-7 weeks. I'm now almost 9 months in. I do remember lots of headaches starting off and feeling nausea and tiredness and dizzy. I think its because it lowers blood sugar. Definitely eating little and often and drinking plenty of water and protein helps.

I’ve lost over 4 stone on 2.5mg, sometimes only taking every 2 weeks. I’d definitely class myself as a super responder. Side effects wore off after a month or so.

Ooh do you mind if I ask something. When you only took every two weeks, was it not like going back to the start from side effects? I’m on my third day of 2.5 and have thrown up around 15 times in 72hrs

Did you get offered an alternative @OneGiddyRubyViewer? Will they trial you on a different medication?

Well, I have appetite suppression today. Ate 6 prunes for breakfast and am going to force myself to eat some toast and peanut butter for protein. I feel bone tired.

I’ve only had one vomit, and my plan is to re jab on Wednesday. The nausea/headaches etc are annoying, the vomiting is inconvenient but I WFH 2 days so I can manage that with timing. The total suppression is not sustainable - I need to make this work which means learning to eat 12-1500kcal and 80mg protein, minimum. I just can’t do it in 2.5, I feel like Christmas dinner every day

It's a bit silly to make up a "tribe" and then snide out on them over something so inconsequential. I think that's a very weird take, tbh, IrisPallida. People are different - and that's ok!

Of course I think this, because I take a low dose! 😉On anything over about 3mg I found I couldn't eat really anything - was struggling to eat 500 calories - and felt so ill I was missing work, which I can't afford to do. So I stay low - between 20 and 40 clicks of a 5mg pen - and that seems to keep me in a sweet spot where I don't have many side effects, enjoy food, but don't feel very hungry and get full quickly. I can make it through about half of a restaurant plate and eat from a side plate at home.

I'm happy to go slower for longer. I've lost 30 pounds in 12 weeks.

Sorry to hear you're being sick. That's horrible.

I'm a super responder, I am sensitive to all meds so not surprised. I took 1.25mg for 3 weeks, and 2mg for the last 2 weeks. I've lost over a stone in 5 weeks.

It's not in my head or placebo. I used to feel physically ill when I was hungry, stomach aches, nausea and headaches. Now I feel nothing. I'm never hungry. I eat my 3 (small) meals a day and that's me good. I eat around 1100 a day.

@Seriestwo I was on MJ for 6 months and never got above 2.5mg. I spaced out my doses to once every 8 days for the first couple of months and forced myself to drink protein drinks so that I got over 1000 calories a day as I really didn't want to lose weight too quickly. Food repulsed me. If I'd known that you could halve the dosage back then, I would have done that. I tapered down that way. I'm not usually sensitive to medication, so it was a real surprise for me.

A little bit of peanut butter is not enough protein. Can you look at ways of incorporating more? I used Huel protein shakes, as I can't digest whey protein very well. It was what got me through!

No real advice as I find that side effects seem to hit me randomly. However I would class myself as a super responder. I moved up to 5mg after 4 weeks but dropped back to 2.5mg as suppression was too much and I had days where I couldn't eat anything at all. Been on MJ for 16 weeks - feeling healthy, full of energy, blood sugar and blood pressure both dropped significantly. Oh, and I've lost 2 stone. It's important to stay on the lowest effective dose and not be rushed into moving up. We're all very different in how we respond.

I’m over 20 stone and just lost 7 pounds in less than a week from MJ (or maybe all the throwing up) it sucks that I have to quit

I have been in 2.5mg for 7 months. At first I was like you and struggled to eat but after a while it let up and I was able to eat ‘enough’ - now I easily eat 3 meals a day and around 1500/1600 calories. I would stick with the 2.5mg, your ability to eat will increase.

Well, it’s jab day for my half dose today and I think it has been much better. I felt tired and headschey, had a couple of casual vomits but have eaten 1300 calories ish and am getting 70-100g protein.

that is sustainable, do you think? I have 5 stones to lose. Once I’m less tired I’ll get back to the gym

“Casual vomits*

no I would say it’s not sustainable to puke every single week

I don’t know her name but there’s a doctor on YouTube who herself lost a lot of weight with MJ, remaining on 2.5mg throughout. She confirms that 2.5mg is a therapeutic does for anyone who isn’t diabetic. It does also serve the purpose of getting your body used to the drug but it will have an impact for most people.

I’m a low doser, never been above 4mg and I’m at maintenance now after losing 60lbs (30% bodyweight) in 35 weeks

However, I’ve never vommed or had the bad shits, the side effects which made me stay on low doses were extreme fullness/delayed digestion which made getting enough calories impossible. Even when lowering doses, my average calories were 1100-1200, eventually getting up to 1300 towards the later weeks, always focused on protein and fibre. The hair loss from fast loss/lack of calories has sucked….

I’d get some pesto bismal for your tummy and give it a few weeks and you might find that eases as you get used to the drug. I personally would do a half dose weekly so your body gets used to the peaks and troughs, until you’re able to tolerate that and then move up. We’re all different though, my friend has been on MJ since Jan, on 12.5mg now and has lost 12lb in 6 months.

This is so helpful, thanks all.

I should have jabbed yesterday but delayed because I wasn’t really hungry. Bit more hungry now but it’s mid afternoon and I ate a bowl of strawberries and yogurt at 0800 and still not bothered about lunch. I’ll jab tonight, stay on the 1.25 until the vomiting stops. It is totally inconvenient for work, I really can’t have that happening!

Casually vomiting daily? No way.