Split dose

[dimplesanddonuts]

I have taken 15 clicks of a mounjaro 2.5mg one around 11am today. Just to see how I react. After a panic attack I realised I’m ok. Is it ok to take the remaining, so 45 clicks on Wednesday, so it’ll be a split dose? Then on Saturday I will just take a full dose?

Your first dose? I’d either take the rest of the dose today or tomorrow, or wait a week between the second half and your next dose. Otherwise there will be too short a gap between the rest of the first dose and the second, which will mean the drug builds up too quickly in your system and you may get increased side effects.

splitting doses once at steady state is fine, but you are still in the building up the amount in your system phase.

It actually may not show full effects until a few days later as can take upto 72hrs to act fully, for me its always 2-3 days after jabbing though i get some effects the next day. Why did you decide to do 15 clicks? That's a tiny amount and won't even reflect 2.5mg and side effects you may get on that. I'd just take the rest of the 45 clicks today and just take as prescribed. I'm on 12.5mg and tolerate it fine with no side effects, i barely noticed 2.5mg and it only lasted 2 weeks for me.

2.5mg is lower than the first dose 5mg used in clinical trials and most people don't react at all. Usually side effects can be linked to food eaten such as greasy, fried fatty food or over eating past feeling fullness. Better to eat little and often and drink lots of water to minimise side effects and eat cleaner, less junk, processed and takeaways. Though most eat a little of what they like and are fine.

No one knows if it is "ok" as it has not been tested that way. The dosing schedule is 7 days for a good reason. Start messing about with it from day one, with no knowledge of the impact is much more risky than following as prescribed.

Stop listening to whoever it is on whatever social media who is filling your head with this nonsense as a new Mounjaro user.

I would inject the rest of the starter dose today (be very careful you only do the balance of todays dose) to get back on track. Or wait 7 days and do the full dose then so you are following a 7 day schedule.

Sounds like you arean over thinker. Just take it as instructed, you will be kicking yourself if it doesn't work. The medication was mediocre all the way up to 12.5mg.

What is the point in this? Just take it as prescribed or not at all.

So if I take the remainder on Wednesday 45 clicks should I wait for the next Wednesday to take the next dose?

🙈 I don't think I will ever understand those who are so nervous about taking a prescribed, extensively tested, low starter dose on a 7 day schedule but are quite happy first dose to play fast and easy with pharmacokinetics based only on posts of unverified randoms off social media.

Everyone is saying just take it on the 7 day schedule as prescribed @dimplesanddonuts , that is the safest next step. You are not going to know how the medication is building in your body if you are messing around with the schedules and you are going to get yourself in a pickle if you want to move to 5mg after your first pen as you will not have been on the full 2.5mg for a full 4 weeks minimum as required.

I will slowly titrate up. I have had side effects since taking the lowest dose. I suffer with acid reflux so last night I was sick and couldn’t eat. I’m going to leave it a week and do 30 clicks. I know some people don’t agree with microdosing. I’m going to then start on a full dose week after.

You must wait 72 hours/3 days before the second dose. Note that day 1 is the day after you have taken the injection.

And note op some people who comment in here aren't on mj, they are just sharing their opinion.

@dimplesanddonuts
Op, you've taken 25% of a non-therapeutic dose, and 2 hours later, all is well. I'm not being deliberately harsh, but I think all you've proven is that you won't have an anaphalactic reaction (which is a very rare response in any event). Is this what you were concerned about? The subsequent panic attack suggests so - all of us were nervous after taking our first dose, that's completely normal, but a panic attack suggests more at play here.

I would strongly advise that you work closely with your prescriber over the coming weeks as you are very likely to experience other anxiety-provoking situations while taking MJ. Listen to what they say, and don't be tempted to do your own thing until you fully understand how this drug works and it's impact on you. You could get it badly wrong and if you go off script, your prescriber will struggle to properly support and advise you.

Please don't start micro dosing it's not how the drug is designed.

You haven’t taken the lowest dose though?

Those are the instructions in the leaflet if you are consistently taking Mounjaro and as a one off exception miss one of your doses.

It does not mean a patient can make up their own interpretation of their prescription instructions and use the guidelines around missing a dose for pissing about with their dosing schedule especially when just starting out.

And note, your post is also only an opinion, the type of opinion that encourages new Mounjaro users to mess around and take unnecessary risks which will cause issues if they either need support from their provider or understanding what to do next in their made up scheduling with no provider support 🙄

I don't even know what the comment suggesting other posters are not on MJ is for? Is it an attempt to somehow dismiss the mostly sound advice, for the OPs safety going forward, that has been given by most posters on this thread to stick to the schedule at this stage of starting?

It's all a bit muddled. Op also said she'd taken first dose yesterday morning but had SEs the night before?
This is why getting medical advice off SM, rather than your prescriber, is so dangerous (it's got nothing to do with people being pro or anti microdosing) - we're advising on incomplete or inaccurate information.

Agree @KrankyKumquat

All this microdosing nonsense drives me bonkers, ask on here what it means and you will get a dozen different interpretations.

The Dr that originally started the all the hype around it even said in an interview recently what she meant by microdosing has been misunderstood and misquoted. She clarified that she talks about microdosing GLP1s in tiny amounts for benefits other than weight loss (reduction in inflammation etc etc) and would not expect weight loss benefits microdosing or encourage it for weight loss.

I get adjusting doses while sticking to the 7 day schedule/4 weeks minimum at each full dose before increasing guidelines, and do it myself, that is very low/no risk. But posts encouraging others just starting on Mounjaro to inject random amounts more than once a week regularly when the risks are entirely unknown, and leaves new patients a bit out on a limb when they don't understand what they are doing, are irresponsible and really annoy me.

@Herewegoagainandagainandagain
This was always going to be one of the risks of introducing millions of people to the bountiful world of private prescribing, with minimal/optional medical oversight. I'm sort of amazed that people are so blasé about messing about with an injectable medication in particular, from day 1, without even an apparently pretty basic understanding of the actions of the medication, the evidence from trials, the rationale for the dosing, the half life, etc, etc but we are where we are.

Sorry, just realised that op had posted about SEs this morning, so after taking dose. Underlines my point though.

Yes but you don't know if the feeling sick is to do with anxiety especially with playing around and excess concern over side effects which led to you messing about with your first dose or your acid reflux or anything else like hormones etc or a quarter of the starter dose of mounjaro.

Hi all. I took a second dose and I’m fine. I was just a bit anxious as I’m very sensitive to medication and during pregnancy had severe sickness daily, which caused me to now have GERD. I’m going to continue on 2.5 and the side effects have been minimal up to now.