Out of date Mounjaro

[MJQs]

I cant seem to find an answer re using MJ once it has been opened for 2 months.

Should we not use it purely because it has possibly lost its initial effectiveness, or is it unsafe?

I have been cutting down as am at target, but still have about 4 mls of the "golden dose" that I could use.

Thanks for any help

No one will know for sure, Eli Lilly will stick to the 30 day instruction, and no one else is qualified enough in Tirzepatide and the uk preservatives used to answer. I have read posts of people being ill in hospital after using long opened pens and others saying they have been fine.

I wouldn’t go that far past the discard date.

"Should we not use it purely because it has possibly lost its initial effectiveness, or is it unsafe?" - they are both risks. The preservative will lose effectiveness and it and the medication itself will begin to degrade. Each time you use the pen and pierce the red seal you risk introducing contamination, and the more times you do that and the longer you keep it the higher that risk. But as WeAllHaveWings says, no one here can accurately quantify those risks.

Thank you @SilenceInside and @WeAllHaveWings 😊

Unlikely to get more out of Eli Lilly than this. Will the medication turn toxic on day 31, no, but 60 days just feels too far to risk it for the sake of one dose.

That is very helpful @WeAllHaveWings thank you x

It's not likely to become toxic, the worst that can happen is that it will become less effective (or possibly ineffective).
Not directly about MJ but a few years ago there was a big study done by the US about whether medicines actually lost effectiveness after their 'use by date'. Apart from antibiotics (which did become ineffective), none of the other medicines trialed were significantly less effective. They chose to extend the 'shelf life' of them by up to 20 years for use by military personnel.
It doesn't necessarily mean we should all ignore expiry dates but it did make me think that a month or two here and there might not make much difference.

@IsItSnowing that sounds like an interesting study. I wonder how many cold storage medications were included and if that made a difference compared to room temp liquids and tablets. Also which preservatives in liquid cold storage medications were studied. Mounjaro has benzyl alcohol as the preservative, for example.

I looked into stability after forgetting to put a delivery in the fridge and, while there is no definite information, as Lilly only test the product for 4 injections within 30 days, the US compounding companies seem to say that peptides are fragile molecules and may be subject to more degradation than a lot of others.
Like others, I would not be averse to a little over but 60 days is quite a time for degradation to occur or contamination to grow