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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Piling the weight back on when stopping MJ

632 replies

Richtea67 · 15/05/2025 19:10

Hi all....I'm so disappointed. I lost 3 and a half stone, have been off injections for a month and regained nearly 7lbs 😩. I was a slow loser (1-2lb per week) and focused on changing habits and reducing portion size rather than diets/calorie counting (this has led to binging previously). I have kept up with a lot of the habits (smoothie for breakfast, cutting out alcohol and healthy high protein snacks). But portion sizes have definitely gone up as I'm hungrier! And I've been more tempted by the biscuits at work and the kids treats! Any advice?? I'm considering re starting if I put too much weight on, but financially this would be a struggle, which is part of the reason I came off them. My starting weight was 14.5 stones, weight when stopping injections 11 stones and at present nearly half a stone back on!! Help!

OP posts:
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BurnoutGP · 16/05/2025 11:35

Crikeyalmighty · 16/05/2025 11:34

I can’t be the only person that knows people who have lost 4 or 5 stone ( not via wli) and have maintained it- give or take a stone or so - they’ve certainly not gone up by 4 or 5 stone again. It is doable for plenty but they have all said to me when I’ve asked that they now weight themselves weekly, and lose a few pounds at first sign of it going up , don’t eat deserts or cake very often at all , those that drank drink far less and every single one has upped their exercise somewhat . This is from people in their 40s to late 60s. They gave all said too they can’t eat as much now they are smaller anyway

I'm quite sure your anecdote and few friends trumps the large studies that have been published.

Twiglets1 · 16/05/2025 11:36

BurnoutGP · 16/05/2025 11:10

But they don't give it as opinion. They give it as fact and advice. Incorrect fact and advice. Which is both damaging and incredibly patronising.

That's just how some people talk ... they give their opinions as facts.

It's ok, we all know people are mainly just giving their opinions on here or their personal experiences.

SuperTrooper14 · 16/05/2025 11:36

BurnoutGP · 16/05/2025 11:30

MJ does not rewire your brain. Most obese people are obese because our brains do not "learn" this. Believe it or not we are not stupid just because we are fat. We know portion size and healthy eating probably better because we have been trying to "learn" our whole lives.

I wasn't going to come back to this thread, but saw you are a GP and have post-grad qualification in diabetes and obesity and I have a question I hope you don't mind answering.

Do you think obesity is triggered by going on a diet in the first place that we never needed to go on? I was 15 when I went on the Hip & Thigh Diet in the late 80s because a family member said I was looking chunky. That diet was the start of my personal feast-and-famine bulimia cycle. I'm now 53.

I look back at pictures of myself at 15 and I was slim and healthy and in absolutely no need of a diet. 😪

samfired · 16/05/2025 11:37

@MicroCrisis I am fat, I'm a non drinking, non driving vegetarian who cooks her meals from scratch and walks everywhere and goes to the gym 3 or 4 times a week. I worry about my weight but my GP says my blood pressure, cholesterol and blood sugar are all perfect, better than most my age.

I gained a lot of weight on a medication I took for a neurological issue about 10 years ago and have struggled with my weight ever since. I don't use a weight loss injection and continue to struggle with my weight.

I think your view of fat people is very ignorant.

BurnoutGP · 16/05/2025 11:40

SuperTrooper14 · 16/05/2025 11:36

I wasn't going to come back to this thread, but saw you are a GP and have post-grad qualification in diabetes and obesity and I have a question I hope you don't mind answering.

Do you think obesity is triggered by going on a diet in the first place that we never needed to go on? I was 15 when I went on the Hip & Thigh Diet in the late 80s because a family member said I was looking chunky. That diet was the start of my personal feast-and-famine bulimia cycle. I'm now 53.

I look back at pictures of myself at 15 and I was slim and healthy and in absolutely no need of a diet. 😪

Yes unfortunately there are lots of studies which show this for many reasons.
Not necessarily the feast/famine reason which isn't really scientific.
But because of rebound weight gain, disordered eating and body dymorphia.
The vast majority of morbidly obese people with disordered eating will have some ACE in their past

Knakeredd · 16/05/2025 11:40

Thanks for sharing this -

"In conclusion, many clinical trials have shown that consuming more protein than the recommended dietary allowance induces weight loss and improves body composition regardless of total energy intake. HPD was also observed to have long-term weight-loss effects and to prevent weight regain following initial weight loss."

Looks at a range up to 1.6g/KG of body weight.

aylis · 16/05/2025 11:40

It's amazing that people are still trotting out the 'quick fix' line when it's clear that most people are trying very hard to make sustainable life changes now that they're not constantly battling food related compulsions. It's making those changes that will give us the best chance of dealing with the cravings and compulsions when we stop taking mounjaro.

MellowCritic · 16/05/2025 11:41

BurnoutGP · 16/05/2025 11:32

That is in fact not in any way shape or form how these drugs are designed. NOT.AT.ALL.
What are your qualifications to state this?

My brother was on the injections himself and this is what was explained to him. He lost 3 stone and didn't gain it back . He struggled to lose weight because he had a large appetite and couldn't control this. He used the time on the injections to change his eating habits , he didn't have the appetite he use to on the injections and as the weight dropped off he was eating better foods which was actually how he lost the weight. The injections interfer with your appetite do they not ? It's not a cure for over eating so I have no idea why you're so triggered by what I said. You can be on the injections and still carry on eating bad quality foods that are high in calories hence why some don't see results. You explain exactly why what I said is wrong or why I need qualifications to speak on mumsnet of all places

BurnoutGP · 16/05/2025 11:44

MellowCritic · 16/05/2025 11:41

My brother was on the injections himself and this is what was explained to him. He lost 3 stone and didn't gain it back . He struggled to lose weight because he had a large appetite and couldn't control this. He used the time on the injections to change his eating habits , he didn't have the appetite he use to on the injections and as the weight dropped off he was eating better foods which was actually how he lost the weight. The injections interfer with your appetite do they not ? It's not a cure for over eating so I have no idea why you're so triggered by what I said. You can be on the injections and still carry on eating bad quality foods that are high in calories hence why some don't see results. You explain exactly why what I said is wrong or why I need qualifications to speak on mumsnet of all places

Because you've trotted out your anecdote as fact and given entirely incorrect advice which is in fact only your opinion/2nd hand anecdote.
Sure for some people like your brother it may show them what they have been doing wrong.
But that is not how this drug is designed.

SuperTrooper14 · 16/05/2025 11:45

BurnoutGP · 16/05/2025 11:40

Yes unfortunately there are lots of studies which show this for many reasons.
Not necessarily the feast/famine reason which isn't really scientific.
But because of rebound weight gain, disordered eating and body dymorphia.
The vast majority of morbidly obese people with disordered eating will have some ACE in their past

Edited

Thank you for answering. So, really, we should be educating our children to never go on diets and just let their bodies be. Isn't it also right that girls in particular gain about 20lbs in puberty but that if you leave it alone the weight rebalances at the end of your teens?

BurnoutGP · 16/05/2025 11:47

MellowCritic · 16/05/2025 11:41

My brother was on the injections himself and this is what was explained to him. He lost 3 stone and didn't gain it back . He struggled to lose weight because he had a large appetite and couldn't control this. He used the time on the injections to change his eating habits , he didn't have the appetite he use to on the injections and as the weight dropped off he was eating better foods which was actually how he lost the weight. The injections interfer with your appetite do they not ? It's not a cure for over eating so I have no idea why you're so triggered by what I said. You can be on the injections and still carry on eating bad quality foods that are high in calories hence why some don't see results. You explain exactly why what I said is wrong or why I need qualifications to speak on mumsnet of all places

https://www.sciencedirect.com/science/article/pii/S0002934325000592

Illprobsregretthis · 16/05/2025 11:48

Blackcordoroys · 16/05/2025 11:31

I second this. It is hard to maintain but it is so motivating to be in lovely clothes and look good. I have accepted I need to weigh myself daily for th rest of my life and not put my head in the sand ever

Well done! I’m near goal but really stressed about coming off the WLI! How have you found it? How long have you been off the meds for? Did you consider staying on a smaller maintenance dose?

Twiglets1 · 16/05/2025 11:48

BurnoutGP · 16/05/2025 11:44

Because you've trotted out your anecdote as fact and given entirely incorrect advice which is in fact only your opinion/2nd hand anecdote.
Sure for some people like your brother it may show them what they have been doing wrong.
But that is not how this drug is designed.

Most users of the drug (for weight loss) don't care about how the drug was designed. They care about how it works in practice and in practice, it reduces appetite in most people which is largely what has made it so popular. So many users talk about the relief of "food noise" being silenced for once, which I presume they mean cravings for unhealthy but tasty food.

MatildaMovesMountains · 16/05/2025 11:54

SilenceInside · 15/05/2025 21:35

It's correct I'm sure, but what is the point in stating it on a thread where the OP is asking for help and support, and the implication is that you're just totally stuffed so give it up? The clinical evidence is overwhelming that you will regain all the weight....and... what? What is the OP, or me when I get to that point, supposed to do about that?

Keep lining the pharmacies' pockets forever?

MatildaMovesMountains · 16/05/2025 11:59

BurnoutGP · 16/05/2025 11:11

You know it's just us stupid lazy fat people! We don't understand what healthy eating and portion control is. ....

I read that post, followed the advice, and 10 minutes later I'm back in my size 12 jeans!!

FortyElephants · 16/05/2025 12:00

MicroCrisis · 16/05/2025 11:28

It's never 'impossible' to lose weight.
Difficult, oh yes.
You would find that out quite quickly if you were unfortunate enough to become unwell, or experienced a food shortage, war, or famine.

I think most of you would find that out, eventually, if you just actually stepped out of your SUV's for long enough to work up a sweat. We might be able to have walkable towns once again!

People have convinced themselves that activity isn't necessary. That there isn't a remote possibility of reducing the volume of food. This is misleading no matter how difficult it is once the body has reached a much larger 'set point'.

The country needs better mental health care for food addiction, that's for sure, and more resources to steer parent's into avoiding their children becoming obese.

If you are very obese then I would imagine you ought to be prescribed the drugs for as long as they benefit your health. Perhaps for all time - same as with blood pressure or statins.

OFDOD

HelloClouds · 16/05/2025 12:01

I've lost 17 lb in the last year by cutting out refined sugar (and gin!). I have a very sweet tooth! I did struggle with sugar withdrawal at first but have got used to it now. I've maintained my weight loss with snacks that I love that are sugar-free (especially full-fat Greek yoghurt pots sweetened with Stevia, granola with no sugar added, or cheese oatcakes with hummus). About once a month I have a home-made cake in a café as a treat. I still eat carbs (potatoes, rice) but smallish portions. I think so long as I keep away from refined sugars, especially in high-UPF foods, I'll be able to maintain this weight without suffering!

AmythestBangle · 16/05/2025 12:02

Do you accuse all the drug companies which make long-term/lifelong medications of "lining their pockets"? They are businesses and they make money out of people continuing to buy their products long-term, of course. So are Cadbury, Nivea and Bisto...they are also "lining their pockets" by keeping us hooked if they can...

Eli Lilly themselves make a number of products that are lifelong medications. No-one is railing against their antipsychotics or antidepressants...

BurnoutGP · 16/05/2025 12:03

HelloClouds · 16/05/2025 12:01

I've lost 17 lb in the last year by cutting out refined sugar (and gin!). I have a very sweet tooth! I did struggle with sugar withdrawal at first but have got used to it now. I've maintained my weight loss with snacks that I love that are sugar-free (especially full-fat Greek yoghurt pots sweetened with Stevia, granola with no sugar added, or cheese oatcakes with hummus). About once a month I have a home-made cake in a café as a treat. I still eat carbs (potatoes, rice) but smallish portions. I think so long as I keep away from refined sugars, especially in high-UPF foods, I'll be able to maintain this weight without suffering!

Gosh well done ...come back and preach when you have 100+lbs to lose....

PlodAlongPolly · 16/05/2025 12:04

Placemarking, some v helpful replies on this thread re: maintenance

AmythestBangle · 16/05/2025 12:05

Gently, I must say that coming on a forum for people who have clearly been overweight enough to be prescribed WLIs, and preaching your radical diet ideas like having sugar-free desserts and leafy veg is...well, bold...

Crikeyalmighty · 16/05/2025 12:06

@samfired as per my previous post I really do feel this is a very individual thing and yes one of those things can be medication that does interfere with weight - we all know people who have been on steroids and their weight balloons, same with some of the drugs for neuro issues etc. of the people I know like this they have found it much harder to lose weight by the usual methods and keep it off which does make me feel that somewhere down the line their body chemistry has changed.

Frostiesflakes · 16/05/2025 12:12

Illprobsregretthis · 16/05/2025 11:09

Hey, if you take it once a month, can I ask how you make sure you don’t go over the 30 days? Isn’t there a thing about not keeping the medication outside the fridge for longer than 30 days? Seems like it would be quite wasteful otherwise?

I just keep it in the fridge until I have used it up
Ive not had any side effect and I’ve maintained my weight by doing this

Tohaveandtohold · 16/05/2025 12:12

Well op, there’s a lot on this thread however my personal experience is I was on MJ for 4 pens, lost 46lbs (BMI of 33 to 24.8) and I stopped. Never went over 5mg because I didn’t want full suppression.
I’ve been off now for over 3 months so almost the time that I was on MJ and my BMI this morning is 23.8 so I weigh less.
What I’ve been doing is I’ve continued to exercise 5 days a week (first thing in the morning at home), lots of weight training, still weigh myself every week, eating well, less carbs and having the right low calorie snacks and lots of fruits at home for when I’m hungry. I have not felt restricted. I will continue to do this. I’m not being smug but I can’t see myself gaining even a quarter of the weight back in 9 months seeing as it took me 11 years of no proper exercise, eating without a care and 3 pregnancies (which I’m done with) to get to that weight in the first place. I cook at home and I don’t drink alcohol.

There has been lots of research on habits and with each day that passes, I’m getting closer to all these new habits sticking.

Long term plan. I’m only in my late 30s so I have a life time ahead. I can’t already commit to being on MJ for life but with each month that passes, I see this as a saving.
IF in 2 years time for example, I slack and start to pile weight back on, when I get to a BMI of 30, I will get the jab again to get it back in control. In that time I would have learnt a thing of two, and I would have saved myself almost £4000 that I would have spent on the jab in that time.
Theres a lot of research that shows how easy it is to pile the weight back and I know if I stopped exercising, I’ll just spiral from there and that’s why I’ve made sure this is the first thing I do everyday. Good luck whichever way you decide to go.

Blackcordoroys · 16/05/2025 12:14

Illprobsregretthis · 16/05/2025 11:48

Well done! I’m near goal but really stressed about coming off the WLI! How have you found it? How long have you been off the meds for? Did you consider staying on a smaller maintenance dose?

I was on the lowest dose for 4 months I think, going from weekly to injections every 10 days. I tracked in my fitness pal every day in that time and really made an effort to find exercise I like (Pilates, swimming). I only lost 3lb in that 4 months but stabilised I think.

it’s worth saying though that I am now the weight I was my whole life hntil lock down when I got depressed and put on 2.5 stone which I couldn’t lose - so my set point might be this weight which is different for others

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