Just had message from supplier saying I can jump to 5mg after 2 jabs - any one else done this?

[Ethela]

"Is it time to increase your dose?

If you last ordered 2.5mg of Mounjaro and have taken at least 2 doses without SE or with manageable side effect, you may be ready to move up to 5mg.

If you’re experiencing side effects that are difficult to manage or interfere with your daily routine, it’s usually best to stay on your current dose a little longer before increasing."

I had a great first week down 9lb - but week 2 nothing so far (day 6) - not had any SE. Should I jump up to 5mg now? I could use both my 2.5mg together - or I could do another week of 2.5 and then combine the 4th and 5th (bonus dose).

I think it means that you can order your next pen as a 5mg pen, not that you should immediately increase your dose to 5mg. The pharmacy are not ever going to suggest or recommend that you do two injections in one week, as that's not in the prescribing guidelines.

Agree with @SilenceInside , it is just a badly worded email. They mean for ordering your next pen.

Remember even without side effects you do not have to move up to 5mg if 2.5mg is giving you the effects you do want - it is a sensible approach to stay on lower doses while they all you to stay in your calorie deficit.

Many still buy the 5mg to give them the flexibility to move up mid month but only take 2.5mg out of the pen by click counting.

The move to 5mg is the only time the dose doubles. I had no side effects on 2.5mg but the first couple of weeks on 5mg were hideous. Don't rush it.

No they are saying you can order the next pen at 5mg, not to use the one you have to take double.

Thanks for the insight. It was me who came up with the idea of using up my remaining 2x 2.5 in one go.

But I think this line is clearly stating you can move up?

If you last ordered 2.5mg of Mounjaro and have taken at least 2 doses without SE or with manageable side effect, you may be ready to move up to 5mg.

'May' be ready. It is a badly worded message or purely a terrible marketing tool that goes against advice.

Which supplier out of interest. Mine has never sent me any push messages.

Its Zava who are the pharmacy wholesaler supplier to Asda.

I use MedExpress and I like them BUT they go full-on marketing at you. I have never gone beyond 5mg and I kind of wish I’d stayed on 2.5 for a second month before moving up, as it worked really well for me. If it’s the same company or a similar high-marketing company they will send heaps of emails. Just ignore until you’re ready to order and order what you think you need. They are not emailing you because you have to or should do it, they are emailing to make a new sale.

They clearly mean you will be ok to move up on your next pen. They are saying if you have had 2 doses without side effects you can order your next pen as 5mg as it looks like you are tolerating the medication so far, not you can start 5mg now.

Finish at least your 4 x 2.5mg doses then if you want to move up.

Reading comprehension fails again.

They mean that if you've had two doses and had manageable side effects at your next pen you can move up to 5mg.

Why are you wanting to rush op?

Your paying through the nose via asda? Why?

Went to Zava direct - was just over £100 + P&P with a 25% discount code.

I read that as you've had two weeks at 2.5 mg, you've got two weeks left. If you've been OK so far, you should be thinking of reordering now, so with no side effects, you should be okay moving up to 5mg when you reorder.

And to answer @TourangaLeila, not everyone can wait around all day for a cold chain courier to deliver, so paying extra for in store pick up is the only other option available.

It isn't clear at all.

I’m going to disagree with almost everyone and say that I interpreted that as you can move to 5 mg after just 2 doses of 2.5 mg. I agree with you OP.
as the 2.5 mg is a loading dose, this would make sense, as for those who fulfill the criteria, it means a rapid move to an ‘active dose’ which enables better weight loss

I have a discount code if you want to DM me.

2.5mg is not a loading dose so your sentence does not make any sense at all.

You are correct - this is from the manufacturers website:

The 2.5-mg dose is for treatment initiation and is not intended for glycemic control.1 The recommended dosage escalation should be followed to reduce the risk of gastrointestinal adverse reactions.
‡Consider patient history and monitor for tolerability and side effects.

https://mounjaro.lilly.com/hcp/getting-patients-started

It’s very clear. This is a prescription medication and you have been prescribed 4 x 2.5mg so that’s what you take. The email is referring to your next prescription.

2.5mg isn’t a loading dose. A loading dose is an initial higher dose that you give at the start of a course of treatment before dropping to a lower maintenance dose.

I use Zava, they really don’t mean that you should only do two doses of 2.5mg and then immediately go to 5mg by doing two injections from your 2.5mg pen. If you want to clarify this, I would suggest messaging the doctors at Zava and asking for clarification.

If you read a bit more on that website it clearly says 4 weeks at 2.5mg before stepping up.

The UK prescribing info
www.medicines.org.uk/emc/product/15481/smpc
"The starting dose of tirzepatide is 2.5 mg once weekly. After 4 weeks, the dose should be increased to 5 mg once weekly. If needed, dose increases can be made in 2.5 mg increments after a minimum of 4 weeks on the current dose.

The recommended maintenance doses are 5, 10 and 15 mg."

It's a badly worded email from the pharmacy but v unlikely they are encouraging you to increase after 2 weeks, rather they are suggesting the next order will be a 5mg pen if you seem to be tolerating it.

@AltitudeCheck you said, The recommended maintenance doses are 5, 10 and 15 mg."

So what are 7.5 and 12.5 pls?

Email the pharmacy and ask them for clarification. I promise they are NOT telling you to go up to 5mg after 2 weeks of 2.5mg. It’s just an email written by an idiot!

@WeAllHaveWings you are incorrect

2.5 mg IS a loading dose. As a clinician, it would not be unreasonable to increase more rapidly IF the patient’s circumstances allow. There are plenty of medications which we would do this with.
however, I do agree that the email is badly worded and confusing and that patients should seek clarity before altering their meds.
ny post was simply to agree with the OP that her interpretation of the email is a valid one