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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Mounjaro 5mg weight gain

3 replies

Bumshell27 · 08/04/2025 07:15

Hi, I’m after some advice. I completed my first (2.5mg) pen last week and lost over 1stone in 4 weeks. I decided to move up to 5mg last week. I feel like it’s done absolutely nothing for me, weighed myself today after completing 1 week on 5mg and I’ve put on 4lb!! Any advice on where to go next? Do I reduce my dose back to 2.5mg as that clearly worked for me or do I reduce to 3.75mg with my 5mg pen. Should I change up my inject point? Helpppp!

OP posts:
Lovegame · 08/04/2025 07:19

Are you counting calories? What is happening with the food you are eating, are you eating more than before?

Are you constipated or retaining water because you’re not drinking enough?

northerneast · 08/04/2025 07:20

Why did you move to 5mg if 2.5 was working so well? Also what have you been eating? Are you tracking every calorie?

WeAllHaveWings · 08/04/2025 07:30

First of all calm down. This is a long term medication, not a quick fix.

5mg gets a bit of a bad rep when a lot of weight is lost on 2.5mg and your body starts to think "what is going on here!" and starts trying to protect itself from more loss. You did not gain 4lbs in one week. Are you hormonal? Did you have a salty/high carb meal yesterday and retaining water? Constipated?

Take the focus off your weightloss and instead think about whether Mounjaro is giving you the effects it should. Is it helping reduce food noise, is it helping you eat smaller portions, keep in a healthy calorie deficit? If it is doing that the weightloss will restart, be patient.

Are you tracking calories and keeping in your calorie deficit?
Are you drinking at least 2L of water a day? - thirst can present as hunger
Are you eating plenty of protein and including protein in every meal? - keeps you feeling fuller for longer and helps with muscle loss

If you feel hungry it might be your body fighting back again the lack for food or nutrition over the previous 4 weeks. Feed it (within reason).

As pp says if your dose is doing what you need (helping you keep within your calorie deficit) you don't need to move up, it makes sense to stay on lower doses while they are working (some providers don't make this clear).

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