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Mounjaro and low mood

28 replies

Hollebob · 01/04/2025 23:02

Hello!
Anyone else suffering severe low mood since starting Mounjaro?
Im on wk 4 of 2.5mg, about to go to 5mg as very little suppression last week and this week.
Ive had low mood before but itd has totally gone (thanks sertraline and CBD gummies-life changing!) since taking Mounjaro tho I can barely crack a smile. I’m ratty with my kids and have lost focus a bit. Normal life has its ups and downs though so maybe it’s that but this is pretty extreme for me!
don’t get me wrong I wanna be thin so bad I’ll put up with it (!) but just haven’t seen many others saying they’ve had this as a side effect so am curious

OP posts:
Mysticmaiden · 16/04/2025 23:34

Reginaphalangeeeee · 16/04/2025 21:34

Sorry you are feeling low too. It was worst when I first started & then improved. My dad died 2 months ago & I have been off work since. Now when I look back I do t know what is MJ effects, what is grief and what is genuine depression.

Sending hugs your way, sorry for your loss

Bigfish51 · 16/04/2025 23:56

Relationships change as your relationship with food changes. My family all miss the food obsessed me who would nip to the supermarket to get ingredients to make gourmet meals at the drop of a hat. Now I prefer to have a jacket potatoes. Everyone has to adapt. My DC are adults so if I don’t feel like cooking it’s up to them or their DF go get their preference. I am no longer a slave to food. It is a time of adjustment. It gets easier as you go up the doses (IME).

Laynie61 · 31/08/2025 18:05

I ve been feeling the same. Have a history of depression but this is on another level. Crying all the time and so anxious. I have decreased from 12.5 to 7.5 in hope it may help but it’s early days

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