Why isn't 10mg working?!

[Alabamasunset]

Why?
Why did I feel strong appetite suppression on 2.5mg and 5mg Mounjaro and I lost weight, but 7.5mg did nothing to suppress my appetite so I've moved up to 10mg and it is having ZERO EFFECT on my appetite. Literally zero effect. To the point where it's as if I'm injecting saline. I'm starving all the time. Food noise is back. I've gone back to feeling just like I did before I ever started MJ and the pounds are creeping back on again since I started on 10mg.
After such a good appetite suppression and weight loss on 2.5 and 5mg, HOW is this happening?! I want to cry.
(From a woman who has tried every weight loss diet known over the past 12 years and am getting heavier every year. I thought MJ was my answer😓.)

How long have you been on it ?

If 2.5mg was working why did you change

You should ask MN to move your thread to the WLI section. You’ll find lots of advice there from people on it.

If suppression was good on the 2.5 and the 5, why did you move up to 7.5? If I were you, I would go back down to 5 again and see if that suits you better.

Have you had any gaps at all? How long have you been plateauing?

Thank you - I will.

Since May

Cos that's what you do

No gaps at all
Plataeuing since October
Gaining past few weeks

It isn’t what you do though really, it’s not a given if a dose is working for you

how much have you lost to date since last May? How far away from target are you?

Cos the correct schedule is that you move up the doses.
Point is I'm gaining weight on a higher dose.

It’s the standard schedule, not the “correct” one. It’s suggested because people on the clinical trials lost the most weight at the highest dose, so the 4 weeks at each level is the quickest way to reach that level. But, plenty of people on the trials stayed on 5 or 10mg if that’s what suited them.

But as you say, that’s not relevant.

I honestly don’t know why things have stopped working for you. Perhaps you have become tolerant to the effects and need a higher dose now. I can’t see how dropping back to 5mg would work, if 10mg isn’t working for you now.

Did you buy it from a proper authorised pharmacy?

People were randomised in the trial SURMOUNT 1. They didn't have a choice which dose they were on nor did they know.

how much have you got to lose and what are you eating?

I would try stepping up the dose.

People were able to move down a dose on the surmount trials if they weren’t tolerating a higher dose. Presumably there was a mechanism for people to report that and have their dose changed even if they didn’t know what that dose was.

The guidance to increase doses every month has pretty much been overtaken by real life experiences, it was still being banded about when I started last June and many followed their providers generic "advice". Whether it was to do with the providers lack of resources/late understanding of how the medication was successfully being used or wanting to sell higher dose pens, I feel many of those providers have let their patients down. What ever the reason was OP is where she is now.

OP, no one will know how you will react regardless of which direction you go in - any option might or might not work. Either, go up, go down, come off it for a couple of months and restart, maybe try Wegovy...

Personally (and I have no experience of this because I have been on 3.75mg for 8 months) - I think I would worry about losing the investment in going up the doses I had already made and I would continue to go up.

I haven't seen any posts yet where someone came off/went down and said the effects came back. Hopefully they will see your thread and respond if they have.

Good luck whatever you try.

You are absolutely right, it is my provider who gave advice to increase my dose. I was told 10mg is the therapeutic dose where real weight loss happens.

I lost 2 stone May to October.
Felt like my weight loss was on fire during this time.
Then plateud Oct to Feb even though I was eating exactly the same calorie intake as I'd eaten when I lost 2 stone, I didn't lose an ounce in these 4 months, no gaps in using MJ, and during this time I increased my doses.
Then I started gaining weight from Feb to current date, having gone up to 10mg by February.
I have another 2 stone to lose to get a BMI of 25.

Yes, 100%.
It's from MedExpress.

I agree, I can't see how that would work either!

I also think you should go up a dose, in fact if I were you I would go up to 15 over the next 2 months without any hesitation. I assume you have recalculated your TDEE for your new lower weight and adjusted calories?

I think there is a bit of a misunderstanding about appetite suppression - in the beginning of taking MJ there is a certain amount of actual appetite suppression but the way MJ works seems to be by increasing satiety rather than by any true suppression. It puts in place the signalling system to stop eating when you have had enough (which so many of us lack) rather than stopping us wanting to eat. The result can be similar and feel similar, but it is not the same thing. The suppression effect seems to wear off after a few months as we become more tolerant of the drug, and it can leave those who are chasing that as the primary means of limiting their intake in a difficult place. I don't know if this applies to you, but it certainly seems that these internet forums are full of people in their early days of taking MJ all excitedly comparing notes about how they can't eat and don't want to eat, and it can make someone who is past that stage feel that something has gone wrong...

How MJ should work, is that you should feel hunger, you should eat a (calorie counted) meal and then you should feel sated until it is time to eat the next meal when you will again feel true hunger and will again find it is satisfied by your meal. Again, if you are expecting to have to force yourself to eat, or expecting to not experience hunger, then this can feel like the drug is not working.

There are things you can do to help as well. One is to really, really limit carbs, and also limit any carbs you do eat to the most complex ones you can. So no sugar or fruit, no carbs like potato, rice (white or brown) or grains, just protein and leafy salads & veg. Maybe a small amount of pulses. This will help get your cravings under control - and this will be possible because the MJ will be trying to help. Low carbing is a fantastic way to stop the blood sugar spikes that can lead to cravings. Later you can start to reintroduce carbs, but meanwhile the key is to find that you can eat without needing to carry on eating past the point where the meal is finished, and that you do not need to eat again until the next meal time.

I have been on 2.5mg mounjaro for 8 weeks and I was bravely moving up to 5mg yesterday well I thought I was until I accidentally injected 10mg! Will I be okay? Long story cut short med express forgot to send me out needle heads with one so I was advised to use insulin needle but I got the dose wrong! (Night shift all week) no excuse really. I’m panicking so much so any advice will be welcomed.