Giving up mounjaro because of anxiety

[mounjaro2025]

Today I have made the decision to stop taking mounjaro. I should have had my 4th 5mg injection, moving up to 7.5mg next week. However I just can’t do it anymore. I’ve been anxious and depressed during the last few weeks, and it’s getting worse - overthinking everything with intense brain fog and not seeing a light at the end of the tunnel.

I am already an anxious person anyway and maybe I’ve got it into my head that mounjaro is the reason I am feeling so overwhelmed by everything. But I’ve read quite a few posts now online that people are suffering with anxiety from taking it and I think I may be with one of them. If I was experiencing fantastic weight loss then maybe I would consider pushing through, but I am not even getting the benefit of that. I also hate how for a few days after every dose I feel like my food is repeating on me and burps taste like food I have eaten 2/3 days prior 🤢

Good luck to those on your journey, I hope the drug works for you.

I have also been struggling with low mood and anxiety.

When I started on mj I had 6 weeks of feeling the best ever! Loads of energy, feeling really positive. I stayed on 2.5mg for my 2nd pen, but after a couple of weeks the effect started wearing off... my supression was less (although still plenty) , the energy boost had gone and I began having some intrusive thoughts around dieting. I also started feeling a bit low and quite anxious. Particularly that horrible feeling where it seems like your muscles are constantly tense!

I'm hoping that going up to 5mg will sort me out. But it is quite worrying. I've wanted to speak to my psychiatrist (I have EUPD and am medicated for anxiety, depression and also take a mood stabaliser/anti-psychotic) but worried they'll tell me to stop taking the mj. Which I don't want - it is working so well and I am so happy to be able to finally start losing this weight which has been put on due to the medication I take!

Why not try a different WLI. I take Wegovy and it has reduced my anxiety massively which was an unexpected side effect. I googled it and found many people have also experienced this.

Do you mind me asking how long you having been taking it?

I felt mj was helping with this up until the last couple of weeks and now it's back with a vengeance!

Hi, I started taking it in September. noticed the difference in my anxiety levels pretty quickly. So it wasn't just a case of losing weight and feeling better about myself and being less anxious. There must be something in the drug which does something with the brain receptors which reduce anxiety.

I suppose if some (MJ) increase anxiety then Wegovy reducing it isn't too much of a stretch

Oh that's great.

I'm on mj and it was definitely reducing my anxiety and intrusive thoughts. But I stayed on 2.5mg for my 2nd pen and after 6 weeks the effect started wearing off and the anxiety came back very badly like a rebound effect! I actually am feeling better this week, though. I'll be starting 5mg soon and hope I get the full effect again!

I went back on mounjaro on a low dose for two after stopping for two weeks from 7.5mg due to anxiety and depression which I am certain Mounjaro was the culprit.

Well the same thing happened, week one wasn’t bad but week two was dreadful with the anxiety particularly and irrational thoughts and foggy brain. First full day after stopping and the fog has already started lifting and I feel happier. I am happy about the weight loss but the mental health issues that came with it make me conclude that it actually wasn’t worth it. These past two weeks have been so rough on my mental health. Good luck on the mounjaro journey

That’s a shame OP, but sounds like absolutely the right decision for you.

I’m really lucky I think, in that even on 15mg, I didn’t have a single side effect. I loved it so much, that I felt anxious about stopping it for the mood boost I felt it gave me. Or maybe I just loved the fact that I was dropping so much weight with ease (53 effortless pounds). Interesting how different people tolerate it. Or don’t.

I’ve watched a podcast of Steven Bartlett, he had a guest specialist on who explained some real disadvantages of these diet injections. 40% of the weight loss is muscle, and if women over 60 have lost weight by this method they will never be able to gain this muscle mass back. Possibly explains why Sharon Osbourne looks so shocking, Robbie Williams also looks shocking, he no longer has any muscle, he looks like a 12 year old boy, shocking.

I get that people want to lose weight but surely this isn’t the answer, so many people are having awful side effects. What are users going to suffer with 5 years from now?

I had a friend who quite frankly bloody annoyed me with all her excuses as to why she couldn’t lose weight. Her diet was shocking and the alcohol consumption was ridiculous, her portion sizes were as large as what a manual worker would eat. She travelled to Turkey for some sort of bariatric surgery but still drank copious amounts of booze. Quick fix products aren’t the long term answer, it’s a mind set that requires changes. I’ve been following intermittent fasting for nearly two years now and have lost nearly a stone in weight, which has taken me back down to a healthy weight for my height.

In Japan they have a philosophy to stop eating when 80% full, in western society this doesn’t seem to be the done thing.

@Snippit Robbie Williams looks amazing on his tour right now?

@Snippit I don't suppose there were any references to back up those statistics and claims mentioned in the podcast?

Sharon Osbourne looks shocking because she has serious issues before she took Ozempic. She was a healthy weight when she started taking it, so she was taking it in a manner that would not be allowed in the UK. She also continued to take it till she was significantly under weight. Again, not something that would be approved in the UK.

Robbie Williams looks normal, not like a 12 year old boy?

I have lost 9st on Mounjaro in a year, I have no side effects and all my health markers are now normal. My health and fitness hasn't been this good since I was in my twenties. It is infinitely better to have lost the weight, and continue to lose weight until I get to goal, than not manage to and probably yo-yo higher as my previous attempts at dieting are evidence of.

I will happily take the risk of as yet unknown dire side effects in 5 years time, over the definite health impacts of remaining more than 10 stone overweight.

I think Robbie Williams is looking really good and certainly not like ant 12 year old boy I’ve known.

@Snippit Steven Bartlett you say? That reliable, never scaremongering, not disseminatimg medical misinformation AT ALL chap?

BBC News - Steven Bartlett sharing harmful health misinformation on Diary of CEO podcast - BBC News
www.bbc.co.uk/news/articles/c4gpz163vg2o?app-referrer=deep-link

Just chiming in to say Robbie Williams looked great on tour recently, very fit and not like a 12 year old boy at all. Sharon Osbourne has been unwell for some time and clearly shouldn't have been taking Ozempic.

I find the idea that women over 60 can never gain back muscle mass very unlikely and rather scaremongering. Of course it will be harder (and that would apply to men too), but it's perfectly possible. And Steven Bartlett is a twat.

Anyway, I would really like to know - has anyone with a history of anxiety (but unmedicated) found it didn't increase their anxiety?

Me! I have only had a couple of episodes of physical anxiety in 7 months since starting MJ. It used to be most days in my chest. I do still get mentally anxious though, it hasn’t gone completely.

Thank you! That's reassuring. I want to start but am worried about so many things (yay anxiety 😂).

Nothing works for everyone and it seems like mounjaro is not working for you. There are lots of different but similar medications in the pipeline that will become available in the next few years. Hopefully you will find one that is right for you.
Not all that many years ago, there was only Prozac as a (modern) AD. Now there are so many options. WLI will go the same way. Hopefully successful oral medications too.

Steven Bartlett is a charlatan and some of the “experts” he gets in are not at all experts.

Im bipolar and 3 weeks in. Have to say so far it’s been positive for my mental health. That said I think I am most likely adhd, misdiagnosed as bipolar and I think MJ has been shown to help adhd in terms of quitening all the noise in your head.

God this has happened to me. Jabbed last Friday, by the following Wednesday I was in the depths of despair. My heart was racing and the anxiety was the worst. It affects your brain chemistry. I definitely think that this rare side effect should be uppped to a moderate side effect. I had to go to the doctors to get some diazepam as I was in a terrible state. Things are starting to ease now and slept last night, but his drug has scared me to death...good luck to all jabbing, but think I will do it the natural way. My mental health means everything to me.

Trust me you are not alone. Recently I moved up to 10mg then 12.5mg mounjaro and my mood has been dreadful. The anxiety has been crippling to the point my husband has had to stay at home. This is not like me at all. I have decreased to 7.5mg last week in the hope it may help

To anyone getting this for the first time, please double check your magnesium and potassium, electrolytes can really really help. Sometimes low sugar can also trigger bad anxiety and panic too. Sometimes the dose is just too high. I was one of those people that got the worst anxiety of my life the very first week - full blown panic attacks and severe anxiety and these things really helped x

I am diagnosed with generalised anxiety disorder but find mounjaro has actually helped me if anything.
Sorry to hear that it isn’t suiting you OP.

What utter nonsense.

Sounds like the right decision for you. I have not heard anyone report it makes mental health issues worse, quite the opposite.

Saxender gave me terrible crippling anxiety. That was a daily injection and it stopped the next day

I haven’t taken Mounjaro, but Wegovy gave me terrible brain fog.

I couldn’t tolerate either. I’m kind of scared to try Mounjaro. I reported both events to Yellow Card.