Mounjaro in tablet form?

[NinaNobody]

I've read this a few times, is it likely?

I am now maintaining but can't afford to keep using the injections.
Would tablet form be cheaper? And obviously the would last longer?

If I could buy an injection and use it for a week on and off it would be more affordable but in it's current format you can't do that because of the 30 day rule.

I just feel like for maintaining it would be great.

Is it just an Internet rumour type thing?

It doesn't exist in tablet form. Rybelsus is the only oral GLP1, but it doesn't have the GIP element.

They are saying likely next year, I’m not sure how effective it will be. There is a tablet form now, rybelus,but it has much less success. It is basically the tablet form of wegovy/ozempic, but for some reason it seems tablets are not as effective as injections.

yes I’d guess much cheaper too. As the sheer logistics associated with cold storage and transportion is expensive.

there are also anothe 8 drugs in final testing, with ozempic coming out if trademark in a couple of years, which means generic label will come to market. It’s a fast moving space.

OP I was on Wegovy and went to fortnightly injections while I was titrating down. It was fine. As long as you are storing it safely in the fridge I don't think the 30 day rule is accurate.

Yes the manufacturers made it up to make money and the fda, Mhra all went with it, as some form of scam,

it is always a risk taking expired meds, which is usually fine.

until it’s not,

I think this must surely be the goal for the manufacturers - I think more people would take it if it had a different delivery method.

It's definitely being researched but I wouldn't hold my breath waiting for it.

Tablets would be dependent on the GI system and digestion and absorption. A lot of people have issues with digestion and absorption etc so it would be less effective than an injection I believe. As someone with IBS, I don't do great with absorption of vitamins etc so I use oral sprays for some which are effective.

Elle Lilly who manufactures mounjaro have already made a statement about it, including anticipated timing as well as the weight loss results on the tablets. It isn’t just being researched it is in final trials awaiting approval.

Yes I know that. I'm still not holding my breath given how often the PR statements are glowing and enthusiastic while we all sit and wait.

It’s not. People on compounded tirzepatide in America are being told 90 days for a vial of refrigerated drug and in Germany they’ve also said that it lasts longer than 30 days. Of course a pharma company won’t be concerned with saving people money and will say only 30 days. And to be fair that’s what they tested in the trials. But they didn’t test 40 days and conclude it didn’t work - they only tested 30 days and 4 doses. Seeing as it lasts opened and unrefrigerated for 30 days, of course it will last longer if kept constantly in the fridge.
The problem is that people just blindly listen to stuff like that and genuinely believe that the vial can only safely be pierced 4 times and that the final dose (I refuse to call it golden 😂) is dangerous (despite being part of exactly the same liquid they’ve been injecting themselves with.

Compounded tirzepatide is different to the medication that Eli Lilly manufacture. It will have different ingredients and possibly a different preservative or other components that affect the storage life.

I'd like to see the instructions in Germany to see exactly what they are saying too.

You can use 5 doses within the 30 days, doing one dose a week, so that's not an issue in terms of the 30 day storage instruction.

@Onceachunkymonkey do you have a link to the Eli Lilly statement about the tablet form of tirzepatide as I'm struggling to find it on their website? I can only find information about a tablet form of a different GLP-1 medication called orforglipron.

https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine

https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine

https://www.clinicaltrialsarena.com/analyst-comment/cardiovascular-inflammatory-markers-orforglipron-easd24/?cf-view

Ah, thanks for clarifying that it is orforglipron that's being referred to as a tablet form of tirzepatide.

@Finallydoingit24 The US have different delivery methods and preservatives in MJ, their instructions cannot be compared.

"The problem is that people just blindly listen to stuff" - So we are not blindly listening, please share who "they" are in Germany and a link to reliable source. Remember not everything you read on the internet is true, especially when you get down to pharmacy level. Both MedExpress and Numan have said previously Mounjaro can officially be used for 6 weeks after first use, only because they rushed their training/website and quoted/copied Wegovy instructions in some places - concerning for a pharmacy and hopefully they have fixed it now. It is possible individual pharmacies in Germany are just as incompetent and therefore it is not reliable information.

@NinaNobody Tablet form GLP1s are being researched by various companies but who knows when they will become available, how effective they will be and the prescribing guidelines. Eli Lilly is even talking about a vision for a one off ANNUAL weight loss injection in the future - both amazing and terrifying in equal measure! Wonder it it means you can't eat from January through to June and it starts wearing off! 😉🤣

For now, for Mounjaro, we have it in Kwikpen form and a discard after 30 day instruction.

You don’t have to do it personally obviously. It’s up to each individual but I seriously doubt that the pen liquid will magically degrade after 30 days when stored in the fridge. I can’t remember where I saw the Germany thing - reddit perhaps - I’m working so I don’t have time to research. Anyway, expiry dates are always an estimate and the company also says 4 doses only yet millions are injecting a fifth dose without any issues. I would personally use a pen for over 30 days but if people don’t want to do that it’s fine.

I always used the 5th dose and also used it at 6 weeks with my last injection. I'm not opposed to dragging it out a little.

It's just so expensive for maintaining.

I think my last injection was 24th Jan and I was 9st

I am not 9st 2.5lbs but my period is due in the next week so I will do another weigh in around the 24th to see what my 1 month, no jabs, weight is

2.5lbs doesn't seem like much compared to the 116lbs I've lost but if I gain 2.5lbs every month I'll be chunky again on a year.

Ah Reddit. That reliable font of drug information,

So you are moving your position from your statement that the 30 day rule is "not" accurate and your opinion that people are blindly listening to "stuff" (official instructions) - to "seriously doubt" and dismissive terms such as "magically" based on having no actual information that America and Germany do something different other than some random posted something once on Reddit (the fountain of accurate medical knowledge 🤔).

Okaaaay then.

It is fine to say I am taking a risk for me personally based on no credible information, but to mislead people and say the instructions are not accurate and strongly imply you do have reliable information is not.

The fifth does is a completely different story as there is the fact to back up that you can inject a 5th weekly dose within 30 days.

Yes the pills are on the way, and I can see them being ideal for maintenance for people like me. I suspect I'll be on these meds for many years to come.

I have lost 4 stone with another 4 to go before I'm at a BMI of 30. I have no goals after that, but in theory I could lose another 5(!!) stone and still be at the low end of a healthy BMI.

I haven't been that weight as an adult. Only as a young teen. And I find that quite scary, so I still haven't a clue just how low is actually appropriate or healthy to take my weight.

At present I'm losing approx half a stone per month which is steady and hopefully sustainable, but it does mean around another 8 months before I really have consider just how far to take this.

Disordered eating, disordered thinking and a lack of self esteem have a lot to answer for, and I need to work on the psychological side of that too.

Hopefully the pills will be available in the next couple of years!