Why am I so unwell after 3 months on MJ?

[justanothermanicmonday1]

Honestly ... so gutted.

Have lost over 1 stone 8lb since November with very minimal side effects. I'm on week 1 month two of 5mg and I have been nauseas the first few days after jab. But for the past week I have had extreme diorreah and sulphur burps to the point I can't even make my work.

Has this happened to anyone else? Why the sudden intolerance? Should I just stop?

I have a GP appointment this week.

Any advice would be appreciated.

I had this with Wegovy last year and it made me stop taking it. I'm now on MJ but only on my second week. No side effects so far. If it happens again, going to try and push through and lower the dose if needed. It is miserable though if you can't be far from the loo!

This happened to me at 5mg. It passes, I think I had it for 2 doses. I then split the dose for the 3rd & 4th week as in half the dose then mid week the other half and kept on the 5mg for a couple more pens. During this time I had to eat very small and often. Mainly soup. I wasn't off my eating plan it was just the jump in medication that triggered it.
Funnily enough 7.5mg had little effect on me and I expected the same reaction but no.

I'm just going to clean up my diet first before i make any decisions.

It's going to be your diet. I found with MJ it's not just that I have to eat smaller portions but the food has to be healthy.

Chocolate and anything with fat had to go straight away.

For the first few months up until last week i was eating really clean and had no side effects. So i know its the diet. I'll go back to basics and eat clean and smaller portions!

I appreciate all your advice and I'm hoping I'll be fit to go back to work this week since I'm cleaning things up!

Oh great advice! Doing that now! Thanks

I agree and I bet most people would side eye someone taking sick leave to get a tummy tuck or boob job

Gone of track bit I would definitely take sick leave to have a tummy tuck. It's my health. I manage others and likewise, sick note is a sick note. The op said she'd had a stressful few weeks so might be unrelated.

Those are cosmetic procedures. I would expect people to use annual leave for them (though not for complications that might arise in recovery) but compare to a gastric bypass if you want a comparable example.

Make sure you are drinking plenty of water to rehydrate. There has been a marked increase in A&E admissions with WLI due to chronic diarrhoea and associated dehydration. Stay off the diet drinks, the sweetener will increase diarrhoea since it is a laxative.
See your GP to rule out other causes. Acute pancreatitis and acute kidney failure are a rare but possible side effect particularly if your BMI isn’t in the obese range.

That’s due to folks taking fake stuff and using too much. There was a rather appalling Mail article where the title was highly misleading, and the article written poorly but basically it wasn’t due to correct usage of legit drugs.

I had terrible diarrhoea and nausea when I went up to 5, as well as fatigue and a general sense of exhaustion. I went back to 2.5 and then worked my way up to 5 with weeks of 3.75, and 4. Peppermint tea, kefir, live yogurt all helped to settle my stomach. I'm now on 5 and feel fine.

Oh it definitely is in the obsess range. No worries about that 😂

I feel I may have to do this! Thanks

I’d cut down on fat. It definitely helped me

I had really bad sulphur burps when moving to 5mg. I was still having the occasional diet coke and I think the gas made it significantly worse. Cut anything fizzy and hasn't been an issue since and have moved up to 7.5mg

Happy to report that I've stuck to small, healthy meals today and I've felt much better. It seems to hit more through the night. I'll report back in the morning. I'll order something tomorrow to help with the sulphur burps. Rancid. But again not as bad.

I think this was the issue. Feeling better this evening.

Great news! Stick with it 💪

Glad to hear it op!

Can I ask what people mean when they talk about clicks? Dh just pushes the button down until then fluid has gone in - then it clicks at the end

Nowhere near 45 clicks etc

help!!!

If it’s a Mounjaro pen that lasts a month, then he will turn the dial until he sees the 1 in the window, each time before injecting. If you turn it slowly it does click. 60 times, so if you want half a dose it’s 30 clicks.

Had a great night and morning and I'm back at work this week. Spoke to the doctor at ASDA online and they reassured me it's normal and pretty much echoed what everyone else said. Thanks again all! X

All the more reason for tighter controls and more face to face prescription. I was prescribed a drug some years ago which caused liver damage. The side effect was known but over 10 years and with increasing use it became apparent that this side effect was occurring too frequently in the general population ( the drug was developed for a specific condition but then licensed for use in other conditions). As the number of incidences increased the drug was eventually withdrawn.
Many drugs start of in niche markets but advantageous side effects mean they are used for off licence conditions without sufficient long term studies.
Mounjaro is a life saver for diabetics but it may not be as safe for healthy wider population.

Tirzepatide, although one of a group of diabetes drugs, was only licenced for use in humans in 2022. Prior to that it was in extensive clinical trials but like most new drugs the impact of the side effects often isn’t apparent until it has been used by the general population for several years.
Just because other drugs in this family are safe doesn’t mean that Tirzepatide will be safe longterm.
So many drugs start off as “miracle” drugs but are ultimately withdrawn when more side effects are discovered.
I have been taking a so called “miracle” drug for a rare condition I was diagnosed with in my early twenties.
I was on the original trial in the UK and it had an immediate affect, which included significant weight loss, but the dose I originally took was reduced once the trial was over and the therapeutic dose was calculated. I didn’t regain the weight but the drug would never have been marketed as a weight loss drug because of side effects.
Thirty years on they have discovered that the drug causes damage to heart valves at the high dose I was originally taking. I now have to have regular echo cardiograms to screen for damage to my heart valves and it’s likely my high blood pressure is a long term consequence of being exposed to the drug longterm.
Hopefully Tirzepatide will not cause longterm side effects, but I after my experience with novel drugs for my endocrine problems I would be reluctant to use it so early on.