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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Longer-term Mounjaro - how has it been?

21 replies

Isthissleepthingworking · 19/01/2025 22:28

Just that really!

if you’ve been on injections for 6m + or so have you
a) lost weight
b) lost as much weight as you hoped
c) suffered from side effects
and
d) how are you keeping the weight off? Have you changed your lifestyle and are you hopeful this can continue?

like many others, I’m seriously considering them (decent amount to lose!) but DO NOT want them to be a yo-yo option.

I’m just really interested to hear how/if they have helped facilitate a true lifestyle change, as that’s what I want/need really.

Thanks! X

OP posts:
SilenceInside · 19/01/2025 22:41

Started Mounjaro at the beginning of July, so just over 6 months now.

a) lost weight

Yes, I've lost 92 pounds so far.

b) lost as much weight as you hoped

Yes, but I am only 57% of the way to my final target weight.

c) suffered from side effects

Yes, on a couple of occasions. Some gastric issues but they resolved and I continued.

d) how are you keeping the weight off? Have you changed your lifestyle and are you hopeful this can continue?

I am not at my target weight. I probably had significantly more weight to lose than you. I have another 70 pounds to lose, or thereabouts. So I will be continuing with the injections for probably another 6 months or so. Lifestyle changes are that I am eating a lot less and moving more. I'm eating better, in that I don't snack and I am prioritising protein and veg over carbs. I particularly don't eat refined white carbs at all really. That's been my preference whilst taking Mounjaro as well as a conscious decision. I just don't want to eat carby things.

I am not a good example when it comes to exercise as I don't do anything formal. I am walking a lot more and generally being more active, simply because it's so much easier for me to move having dropped the weight that I have so far.

All weight loss methods have a risk of weight regain. It's something that you have to think hard about whilst losing the weight. The advantage of it taking a long time to come off is plenty of time to embed small changes. Plenty of time to plan for and psychologically prepare for maintaining. I'm not just going to stop taking Mounjaro and assume that I don't need to think about keeping the weight off.

Isthissleepthingworking · 19/01/2025 22:48

That’s very interesting, thank you.

I do have quite a bit (5+ stone) to lose, so hear what you are saying about having the time to start implementing healthier habits gradually - that’s good to think about. I imagine maintenance is a completely different ball game - but as you say all weight loss methods do have a risk of regaining. Food for thought!

OP posts:
Persista · 19/01/2025 22:52

Been on it for a year and have lost the 2.5 stone I needed to lose. I was a slow loser but I didn't mind. No side effects whatsoever.
Looking at maintenance now.

onwards2025 · 19/01/2025 22:58

I've been on it since April

(a) yes lost weight
(b) a lot slower than others - I lost 2 stone quickly within first 12 weeks, then another 7lbs ish quite quickly, then plateau with +/- 5lb range for SIX long months. Have now started losing again and have now hit 3 stone loss overall.
(c) side effects, none that have overly bothered me. At times have had headache, diarrhoea/nausea but has settled quickly, mainly around times I've upped the dose. I felt worse on saxenda.
(d) tricky as I've had such a long plateau until recently so has been very like taking mounjaro to maintain rather than anything else. I've previously had similar loss with saxenda and went on to regain all of it within a few months after stopping it so I'm determined not to do that again but reality may be that I will need to stay on a low maintenance dose.

I need to lose 2.5 stone stills. I think it's likely I will be in on mounjaro all this year at least

Snozzlemaid · 19/01/2025 23:08

I started at the very end of May 2024.

a) lost weight - I've lost 75lbs
b) lost as much weight as you hoped - more than I could have hoped for
c) suffered from side effects - had a couple of days of diarrhoea after a few weeks on 10mg. Reduced my dose and all settled down again. Most noticeable side effect for me is that I'm so cold all of the time now.
and
d) how are you keeping the weight off? Have you changed your lifestyle and are you hopeful this can continue? I've not reached my goal yet. About 2.5 stone left to go. When I get there I hope I can continue with the habits I have learnt around food, but I'm not opposed to staying on MJ long term if necessary.

WeAllHaveWings · 19/01/2025 23:17

a) lost weight - 30 weeks, 75lbs and counting
b) lost as much weight as you hoped - more and quicker than I expected, sometimes think it's been too fast
c) suffered from side effects - fatigue in first few weeks, occasionally mild constipation, menopause symptoms got worse so have started HRT, hair loss from rapid weight loss, excess/loose skin
and
d) how are you keeping the weight off? Have you changed your lifestyle and are you hopeful this can continue? - not on maintenance yet, eating less moving more, but accept I am likely to continue this with a Mounjaro maintenance plan long term

You never asked about other benefits - swollen ankles disappeared in first 3 weeks, BP is significantly lower hopefully will soon be of meds, acid reflux gone and no longer need daily omeprazole, and.........soft and smooth elbows 😂

SilenceInside · 19/01/2025 23:28

Oh yes, my swollen feet disappeared pretty rapidly. Also my BP is down to optimal/normal from top end of high although I'm still on medication but not having to change or increase it. My sleep is miles better too. Also my general happiness has increased, I was pretty darn miserable when at my largest and I am pretty darn pleased with where I am now.

Isthissleepthingworking · 20/01/2025 12:00

The other benefits are really interesting too! All for a smooth elbow (and less puffy ankles!)

I guess (probably very naively) I am hoping to not have to go on it long term in maintenance phase, as I think that is the unknown bit about in terms of longer term health outcomes and risks that we don’t know yet. However we do know the risks of obesity - and they are many!!

OP posts:
Shrinkingrose · 20/01/2025 12:52

Isthissleepthingworking · 20/01/2025 12:00

The other benefits are really interesting too! All for a smooth elbow (and less puffy ankles!)

I guess (probably very naively) I am hoping to not have to go on it long term in maintenance phase, as I think that is the unknown bit about in terms of longer term health outcomes and risks that we don’t know yet. However we do know the risks of obesity - and they are many!!

I think we do know, the drugs have been in use for over 20 years in various guises and 15 years in trials before that. So I think 35 years is long enough?

Isthissleepthingworking · 20/01/2025 14:52

Shrinkingrose · 20/01/2025 12:52

I think we do know, the drugs have been in use for over 20 years in various guises and 15 years in trials before that. So I think 35 years is long enough?

I mean that is true - but I guess on a larger population scale? I’m very pro, I just have a few niggling thoughts!

OP posts:
stealthsquirrelnutkin · 20/01/2025 17:01

I've lost 11 kg since starting Mounjaro at the end of June.

At that time I was already 28 months into my weight loss journey and 69 kg down from my starting weight so I wasn't expecting dramatic weight loss.

Mounjaro is helping me reduce my daily calorie intake to more normal levels. Up until December I was eating between 2000 and 2200 calories/day and losing around 1.5 kg/month. In December I didn't lose any weight (for the first time in 33 months) so I reduced my calorie allowance to 1700/day, which would have been impossible without Mounjaro.

1700 calories/day turned out to be a bit too low, when I weighed myself after 3 weeks I'd already lost 4 kg, so I've raised it back to 1800 calories/day to slow the weight loss.

I have another 13 kg to go to reach normal BMI, and I want to keep the extra calories in reserve for the final furlong. Also, I lost weight very quickly for the first 18 months and still haven't reabsorbed all the loose skin yet, so I'm happy to keep the weight loss at around 1.5 kg/month and only reduce my calories again if it grinds to a halt (like it did over Christmas).

No side effects at all. Not a twinge.

Ilovethewild · 20/01/2025 17:20

I started at 118kg
started aug, lost about 3stone,

was on 7.5mg but side effects were too bad and I stopped injections in Oct for a few weeks and then went back to 2.5. I was worried about gaining, but I continued to lose weight but not at a fast rate.

i have not had jabs for 3 weeks, still losing as I certainly have lost a lot of the food noise.

i want go back on jabs, as i found it really helpful on 2.5, I worry about my eating, esp at night. On the jabs, the desire to eat was massively reduced.

It was only Christmas and ££ that meant I didn’t go back already. It is pricey for me. But very worth it.

everyone is different, but it has certainly helped me and I can see that it may not need to be long term for me (I had expected 1 yr and possibly maintenance plan but I think that is anxiety about weight returning.)

im 58, 5ft 5 94kgs now.
about half way for me.

butterfly0404 · 20/01/2025 17:29

Slow looser here, 7 months on MJ, started 22nd June.

55 pounds lost , looking to loose another 9 to get to target but have stalled somewhat and have actually gained a few pounds despite maintaining appetite supression.

Blood pressure reduced loads, elevated rather than stage 2

Fatty liver reversed

Skin looks so much better and I feel much healthier and told I look 10 yrs younger.

Joints feel much less achey, has helped my arthritis

Cons - terrible hair loss, using Minoxidil to try and treat

Possible B12 deficiency/aneamia - blood test next week

Aready very bad constipation much worse but did expect this as I have an underlying condition

Sulphur burps - had these throughout.

I'm on 10mg resisting going up for my last push due to these side effects However I would put up with almost any side effect to have lost nearly 4 stone.

Isthissleepthingworking · 20/01/2025 21:46

That was another question I had - loose skin!

I was worried if it is rapid weight loss (more rapid than other
methods I guess) that it would be really quite obvious? Not a reason not to really but was curious.

OP posts:
IdrisElbow · 20/01/2025 22:03

This reply has been deleted

This has been deleted by MNHQ for breaking our Talk Guidelines.

SilenceInside · 20/01/2025 22:09

I haven't got loose skin as yet, but I still have 5stone to lose, so maybe when I get nearer to target it might appear. I'm not very toned or muscular, so that's something I need to work on, that I think might help.

It's not really avoidable, I think it's mostly down to genetics and how much weight you lose rather than the speed of the weight loss itself.

FerretChops · 20/01/2025 22:39

Been on it since last April and have gone from 15 stone to 9 and a half. So yes, I have achieved what I wanted to achieve

Currently on 7.5 which is the highest I got to. I'm now considering maintenance

I never needed to embed new habits or learn about how to eat properly. So will I put the weight back on if I stop taking MJ? Yes probably - most people will over time, with the best intentions in the world

I intend to taper down to a low dose and see how i go , under the guidance of a maintenance plan

justteanbiscuits · 21/01/2025 11:15

stealthsquirrelnutkin · 20/01/2025 17:01

I've lost 11 kg since starting Mounjaro at the end of June.

At that time I was already 28 months into my weight loss journey and 69 kg down from my starting weight so I wasn't expecting dramatic weight loss.

Mounjaro is helping me reduce my daily calorie intake to more normal levels. Up until December I was eating between 2000 and 2200 calories/day and losing around 1.5 kg/month. In December I didn't lose any weight (for the first time in 33 months) so I reduced my calorie allowance to 1700/day, which would have been impossible without Mounjaro.

1700 calories/day turned out to be a bit too low, when I weighed myself after 3 weeks I'd already lost 4 kg, so I've raised it back to 1800 calories/day to slow the weight loss.

I have another 13 kg to go to reach normal BMI, and I want to keep the extra calories in reserve for the final furlong. Also, I lost weight very quickly for the first 18 months and still haven't reabsorbed all the loose skin yet, so I'm happy to keep the weight loss at around 1.5 kg/month and only reduce my calories again if it grinds to a halt (like it did over Christmas).

No side effects at all. Not a twinge.

Wow! I envy you being able to eat 1800 cals and lose weight!!! I need to eat under 900 to lose 2lb a week!

Slibberydibbery · 21/01/2025 12:52

OP just get them ordered.

They’re going to change your life - you can worry about maintaining etc once you’re at a point that you need to think about that.

Don’t let possibly feeling cold, some nausea or constipation hold you back. Whether you’re a slow loser or fast depends on many factors, you won’t know until you’ve tried them.

Isthissleepthingworking · 21/01/2025 23:36

Slibberydibbery · 21/01/2025 12:52

OP just get them ordered.

They’re going to change your life - you can worry about maintaining etc once you’re at a point that you need to think about that.

Don’t let possibly feeling cold, some nausea or constipation hold you back. Whether you’re a slow loser or fast depends on many factors, you won’t know until you’ve tried them.

This is very sensible advice! Thank you

OP posts:
stealthsquirrelnutkin · 24/01/2025 15:35

I was morbidly obese so my basal metabolic rate was high, now that my BMI has dropped to 29.5 I expect it will get harder as I get closer to normal weight. Google tells me that 67 year old women need around 1700 calories/day (what a swizz I always thought it was 2000 for women) so I'm resigned to getting used to that, but I don't want to go lower than 1500, so it may take a long time to hit a BMI below 25.

After a lifetime losing and gaining massive amounts of weight I have finally realised that when I reduce my daily calorie allowance to the point of living with constant gnawing hunger my metabolic rate slows down, and so does the rate of weight loss. I now I stay within my calorie allowance for a week or two and then have a big blow out where I scoff 600 extra calories or more, which doesn't seem to have any negative effects, on the contrary it convinces my metabolism that there isn't a famine so it doesn't feel the need to slow down.

When I did the Lighter Life diet 15 years ago it provided 800 kcals/day. You were only supposed to stay on it for 3 months, but my consultant allowed me to continue until I hit my goal weight which took just short of 6 months. Towards the end of that time, despite not cheating and drinking 2 litres of water each day I didn't shed any weight at all for several weeks in a row. The consultant assured me that it was normal to hit a plateau and I just needed to keep at it for the weight loss to resume.

She was right, I did finally lose those last few pounds, along with great handfuls of hair that fell out leaving big bald patches. Looking back it was insane to believe that all the nutrients I needed were provided in the synthetic powders inside the expensive sachets. The damage done to my gut microbiome from subsisting on that shite for a half a year must have been catastrophic.

I did lose a bit more than 6 stone by sticking to it without cheating, but within a couple of years I'd regained all the lost weight and a good bit more on top. So forcing myself to swallow artificially flavoured and sweetened shakes and slimy soups had been worse than useless. Even more annoyingly everyone seemed to assume that I was a complete slob, with no interest in improving my health because I hadn't managed to keep the weight off afterwards and had regained it all so quickly.

I had been vegetarian since 1982, eating a very healthy diet. At least that's what the dietitian told me decades ago, when I was first diagnosed with diabetes, and I handed her my homework listing what I had eaten in the past week. She said she wished she ate as healthily, and the only thing she would change would be portion size. I don't blame her because she was following the NHS guidelines, which advise massive amounts of wholegrain carbs (6-8 slices of bread), plenty of vegetables and fruit and smaller quantities of protein.

I happened to catch a Zoe food science podcast back in February 2022, when I was bedridden with agonising rheumatoid arthritis (which ground like someone had poured sand in every single joint, making the slightest movement agony). The guest scientist on that podcast was describing an experiment they'd completed, where the test subjects were required to add 6 small portions of fermented food to their normal diet every day without making any other changes, the control group carried on as usual. At the end of the trial period the group eating the fermented foods had lowered the inflammation markers in their blood by 18-20%, which sounded like magic to me, as I was counting down the hours until I could safely take my next dose of paracetamol.

They talked about the most active fermented foods being Kefir, Kimchi, (sauer)Kraut and Kombucha - the 4 Ks. I went online, added a couple of tubs of plain kefir yogurt to my next grocery delivery, and set up a subscription with lovingfoods.co.uk to send me jars of their different flavours of kimchi, sauerkraut and kombucha every 4 weeks, kept listening to each new podcast, following the advice, and never looked back.

To keep track of what I was eating I reanimated an old myfitnesspal.com food diary, and logged everything I ate religiously, without trying to make any other changes apart from adding the 4 Ks. Each day when I completed the diary the page warned that if I kept eating that same amount each day I would have gained another 3-4 kgs in five weeks. After a few days of seeing the warning I decided I ought to weigh myself and keep track of the inevitable weight gain.

Unbelievably the scales said I was down 10.5 kg since my last diabetic appointment (and that was before the Christmas holidays, when my size 36 waistbands had all grown uncomfortably tight) I naturally assumed the batteries must be on the blink. A month later after installing the new batteries I climbed on the scales prepared to face the terrible truth, only to see that I'd lost further 9.1 kg.

Despite eating well over 3000 kcals each day over the past 60 days, and with the myfitnesspal diary predicting massive weight gain at the close of each completed day, I'd somehow managed to lose 19.6 kgs, and the only change had been adding a few tablespoons of kimchi and sauerkraut every day along with a bowl of kefir (with defrosted berries and a teaspoon of inulin) and half a glass of kombucha.

Ever since I've been an evangelical convert to the power of pandering to the gut microbiome. It has been an absolute game changer for me, as well as other people who've been influenced by noticing the changes and finding out how little effort I'd put in.

My diabetes consultant was fascinated when I saw him that first autumn. He had become inured to gradual deterioration in his patients, and was dead chuffed to see someone my age (65 back then and diabetic for 30 years) turning it around. He spent the appointment questioning me about what changes I had made.

A year later, at my next appointment he actually remembered who I was, and thanked me for inspiring him because he'd downloaded the Zoe food science podcasts and the small changes he'd made following their advice had shifted the little paunch that had been growing steadily despite everything he tried to do to get rid of it. He'd been following the NHS "food pyramid" dietary advice just like me, and despite walking to work in all weathers he'd been gaining weight since hitting middle age. Eating different fermented foods each day, increasing the variety of different plants he ate in a week, a daily spoon of inulin soluble fibre, and fasting for 14 hours overnight worked just as well for him as it did for me. He wasn't morbidly obese, he was probably hovering between normal weight and overweight so his results weren't as dramatic, but the year before he had a little gut like football, and the following year it had vanished, and he was delighted. I just hope he is spreading the word amongst all his other hopeless cases.

I sometimes suspect that the gazillions of tiny bugs inside my gut are controlling me. Perhaps it is them that make me shudder when I read the ingredients list on a packet of Mr Kipling's French Fancies, and has me blithely brewing my own kombucha, fermenting my own kefir and forking out £12.50 a week to have Loving Foods keep me supplied with those jars of fermented vegetables they find so delectable. They've certainly changed my sleeping habits, after suffering from insomnia since my teens I now find myself in bed by 10.30, asleep by 11, and up again at 8 ready to face the day (instead of glaring at the ceiling till dawn, then having to drag myself out of bed in the mid afternoon).

I still have the impressive collection of autoimmune ailments that collected over all the decades when round the clock eating never allowed my guts to rest, repair, and produce all those short chain fatty acids that are so important for regulating the immune system. Still, I haven't had a major flare up of the fiendish rheumatoid arthritis, or a bad asthma attack since starting the dietary changes. Though infuriatingly, when the rheumatism receded, a lupus inflammation targeted certain damaged muscles and tendons, and remains, causing various annoying pains and just waiting to flare up and spread to other areas whenever my resistance is lowered, as happens when I catch a cold that hangs around for too long.

Fecknose what kind of a state I'd be in if I hadn't made the changes. Still bedridden, probably in a care home, or dead.

A couple of days ago I was dragging a 12 kg parcel across the floor before struggling to heave it up onto a table to be cut open, and it struck me that just 34 months ago I was somehow managing to hobble about carrying an extra 80 kg of lard everywhere I went. Carefully packaged, but still 80 kg, that's more than 12 and a half stone in old money!

I feel swindled, I ought to be bounding across the hills like a gazelle, or floating up into the sky, like an air balloon with an 80 kg sand sack thrown overboard. Yet here I am still hobbling around painfully (bastard lupus) with a right leg that delights in collapsing out from under me.

Grumble, mutter, grump... OK so improving the gut microbiome also improves mood, and mental health, but I've never been the kind of saint to deny myself an enjoyable grumble and really it's just not FAIR! I want to bound and soar, not hobble along leaning heavily on a couple of sticks and swearing (hopefully under my breath) about treacherous leg bastards.

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