Eli Lilly CEO expects new weight loss pill, Orforglipron, to be approved next year

[TirzepatideUser]

https://www.google.com/amp/s/www.cnbc.com/amp/2025/01/13/eli-lilly-new-weight-loss-pill.html

Eli Lilly expects its experimental weight loss pill, Orforglipron, to be approved as soon as early next year. Data on the tablet are expected to be ready within the next six months, which could lead to approval as early as 2026.

The pill is part of a class of drugs known as incretins designed to mimic the action of the GLP-1 hormone. Drugs from the class are also being tested to treat or prevent Alzheimer's by helping with underlying conditions like obesity and stroke that lead to cognitive decline.

Eli Lilly has said Orforglipron helped patients lose up to 14.7% of their weight in a mid-stage trial, compared with 2.3% among people who took a placebo.

https://medwatch.com/News/Pharma___Biotech/article17804939.ece

https://www.reuters.com/business/healthcare-pharmaceuticals/eli-lilly-exec-expects-obesity-pill-data-april-2025-2024-06-10/

Good news!

Yes, I think also eight other drugs about to be approved also. As in 8 brand new drugs. And I understand one of them is one that targets 3 receptors. Mounjaro targets two and wegovy, one.

once pills become available, then the price will start dropping significantly,

@Onceachunkymonkey Yes you're right. The drug youre talking about that targets 3 receptors is Retratrutide. I also posted about it some time ago.

https://www.mumsnet.com/talk/weight-loss-injections/5207996-retratrutide-a-triple-hormone-receptor-agonist-meds-for-weightloss?reply=139752203

Also yes the pills are expected to be cheaper both for users and the companies to produce, therefore easier for more people who qualify to be able to afford them, hopefully (or the NHS can prescribe them too).

Incredible to see more life-saving drugs incoming.

Yes it’s fantastic, and the pill format will make such a difference, as the whole manufacture an injection, and for it to require cold storage , costs a lot all the way along the supply chain. Pills will be signficantly cheaper and I’m hoping the nhs will change their stance and widen roll out when they become available.

as usual once they develop this science, they can continue to improve on it. It’s going to be a fast moving space.

I'm fully anticipating these pills to be the maintenance regime I'll be on for the rest of my life.

Since starting on Mounjaro I've gone from 10+ days of migraine each month to max 1. That on its own is worth every penny to me.

These pills hopefully will make maintenance programs more simpler and affordable

Wow @CornishPorsche - that is incredible. I wonder why the medication has been so effective for migraines? I wonder were they insulin or blood sugar related?

I really hope the pills are as effective as the injections and cheaper and that they are made more widely available to those who really need them. I heard a news snippet yesterday that they estimated that if the NHS were to prescribe the current injections to everyone in the UK who is suitable that it would cost £10 billion and bankrupt the NHS. Of course that doesn’t take into account the health benefits of the medications and the inevitable long terms savings to the NHS.

I'm really hoping these will be a good alternative to the jabs for maintenance too. I wouldn't change from MJ for weight loss at the moment as it is working well but pills would be a lot easier longer term.

It seems less effective than mounjaro, if only 14 percent weight loss. I think that’s similar to wegovy.

altnough I don’t quite get these stats, as the drugs are basically a tool, to help us diet.

@Onceachunkymonkey - I haven’t looked at the stats to be honest. I know the semaglutide pills - Rybelsus - aren’t as effective as the semaglutide injections as I’ve tried them.

Must admit, now I have gotten over my (tiny!) needle fear, and I am in the swing of injecting once a week I like the once a week routine and then forget about it instead of a daily pill.

So it depends on the cost difference / effectiveness, but good to know more options could be coming available for those who cannot do injections for whatever reasons.

Presumably that's approved for the US market sometime next year. I wonder whether they've applied or will be applying for MHRA approval in the UK and what the timescales for that would be.

Although they have a lower effectiveness compared to MJ they could well be what we are looking for in terms of maintenance.

Agree, hopefully we can move over..the issue is, say you’ve done a year on maintence with mj, will the risk it doesn’t work be worth it,..

I have 21ibs left to lose another year or so on Mounjaro. I am hoping the (presumably cheaper) pills may be an option to support maintenance.

This is good news. I need to lose serious weight but I can't inject myself so having a tablet choice would be wonderful. My AI causes the weight which then cause other health conditions so I really need to get off this destructive merry go round.