Anyone else not building tolerance to Mounjaro?

[ChunkyMunky]

All the dosage guidelines for Mounjaro suggest that your body will build up some tolerance to the medication. You start on a low dose, and increase every 4 weeks, or stay the same if you have enough suppression. Supposedly.

I’m currently on week 14 and don’t appear to have built up any tolerance at all. My first 5 weeks were blissful on 2.5mg, great suppression, and mild, manageable side effects. Suppression began to dip a little towards the end of my pen, so, as recommended, I went up to 5mg. First two weeks on 5mg were a bit rough, third week was horrific. I had awful cramping, vomiting and diarrhoea and needed time off work because I couldn’t stay out of the bathroom for more than 5 minutes. It was horrendous.

I took a half week pause to recover, and then dropped back down to 2.5mg. Since then, I’ve had horrible diarrhoea and cramps most weeks, consistently 24-48 hours after the jab, and lasting for 3 or 4 days out of each week.

I’ve tried eating more. I’ve tried eating less. I’ve increased fibre, reduced fibre. Tried over-the counter remedies. It’s just awful, for half of each week.

I don’t want to just give up. I’m losing weight, I’m at the lowest weight I’ve been on 13 years, but I’m not even half way to a healthy bmi yet, so I want to keep going, but preferably without the diarrhoea! Debating reducing my dose again, maybe down to 1.25mg.

Has anyone else had similar? Where is this tolerance that my body should be building up?

I know nothing about it, so not much help, sorry, didn't want to read and run. Is there the possibility to switch to Wegovy? My understanding is Mounjaro has two GLP-1 receptor agonists and Wegovy only has one and so might you possibly get less side effects with Wegovy if your body simply cannot tolerate the Mounjaro?

An idea. Stay off it for a few weeks, then start again at 2.5 and stick at 2.5 for a couple of pens, see if that maybe helps??

Have you tried increasing protein and electrolytes? That's sorted diarrhoea, dizziness and headaches I was having. I use my fitness app to reach my protein goal and log food.

Definitely reduce the dose back to 2.5, you could split it in half across the week maybe? Recommend you speak to your prescriber for help.

Thanks all. I’ve been on 2.5mg again for a few weeks now. Think I’ll try 1.25mg and see how that is. If that has the same results it may be time to think about stopping, but I really hope that’s not the case.

Getting plenty of lean protein, so don’t think that’s the issue.

It’s just really odd that I’m less tolerant now than I was in the first month.

Hope Eli Lilly start offering tiny 1.25mg pens for sensitive individuals or those looking for low dose maintenance, but doubt there’s enough demand. I seem to be a bit of an anomaly.

There are a few of us that did ok for a while on Mounjaro and then developed an intolerance even on lower doses than we had been doing fine on before. I have gone back to Wegovy (hence the name) which I was on for ages before without these problems. So far so good but I am only on the lowest dose.

That’s interesting @BackToWegovy , I’ve never tried wegovy, but will bear it in mind over the next few weeks.

Feeling better today, thankfully. Will keep an eye on things for the rest of the week before deciding what to do next.

I was fine on 2.5mg but have had a grim time on 5mg. Haven't got used to it at all. Horrid nausea and can barely eat for 5 days, and constipation. Day 6 and 7 have been better and I haven't actually done my jag today because I can't face the nausea again! Maybe some people are more sensitive to it than others aye.

To be really honest, you sound like an anomaly to the extent that you should stop using it. Medication cannot universally suit everyone and it sounds like it’s not the right one for you. I’m sure anyone would lose weight if they had constant diarrhoea, vomiting and cramps.

I've recently started on Wegovy as I wasn't suitable for mounjaro. I have RA.
I had one day of huge D& V and a mild headache but that's it. This is my second week and the burps, headache and constipation have disappeared.
I can't drink fizzy drinks or eat anything fatty. Not a huge weightloss (2kg week one) but I wasn't looking for massive results as I had recently lost five stone on my own. I'm also older. Tbh I was upset I couldn't have mounjaro but on further reading I think I'll stick with wegovy as it seems less invasive (just my opinion).

Yes I am like you, I have had severe diarrhea now for 5-6 weeks and it's driving me nuts.
The diarrhoea started when my dose was increased to 7.5mg so my GP has just reduced it back down to 5mg but I still have severe diarrhea. I'm not sure if I still have 7.5 in my system but I can't go anywhere or plan anything. If the diarrhoea doesn't stop then I think I will come off the mounjaro completely.

This is my worry though I’ve not started yet. Have you tried taking loperamide?

I'm really struggling with Mounjaro. I've had awful side effects from week 3 which wipe me out for at least 2 days a week. Stomach cramps, severe diarrhea and nausea. I'm only on 2.5 mg and have stayed on this dose for an extra month but I don't seem to be building a tolerance. The symptoms start around 3 days after I inject. Going to speak to my prescriber as I'm ready to give up but I'm so bitterly disappointed 😞

Hello, I did 2.5 in October, November and upped to 5 in December which was horrific.

I then dropped down to 2.5 for 2 weeks but still had side effects.

I then had a break because I felt like my body needed it with all the sickness etc I was experiencing, and started again in March on 2.5 and I'm still experiencing the same pains.

I'm bloated, up with diarrhoea all night, stomach pains, horrific burps, sickness. I had this first time round on 5, and since I reduced.

I'm eating well and mostly chicken, drinking loads of water.

I'm losing weight but paying the price with the side effects.

I'm going to reduce my dose to 1.25 on Sunday as I think I'm just really sensitive to it. I really suffer.

I'm on my second month of 15mg, and I don't feel it to be working... I always inject in my thigh, but I've just done my last dose in my arm to see if that has any bearing. I have read that you can build up resistance. To GLP-1... but I don't know what else to try

I'm on week 8 and my 3rd week of 3.75 so 45 clicks of a 5mg pen. Suppression is great and side effects minimal. Slight nausea on day 1 &2. Will stay on this as long as it's working and only move to 5mg when I need to.