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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

15mg mounjaro stopped working

34 replies

missingthemidlands · 21/10/2024 16:00

I’ve only lost a small amount of weight but enough to keep happy with, have been on 15mg for two months now and I’ve noticed all the food noise is back.

does anyone have any ideas on what to do now? Am I doing something wrong? This was the only thing I’ve ever managed to lose weight on and I’m on highest dose so can’t increase. Feeling a bit low!

OP posts:
Ozanj · 22/10/2024 14:46

I have pcos. I never had food noise suppression. I eat normally (ie a lower carb mostly wholegrame diet - you can’t give that up) and have been losing weight consistantly. With pcos absolutely do need to watch what you eat while you’re on the jabs.

IrisPallida · 22/10/2024 15:30

missingthemidlands · 21/10/2024 18:43

I’m 33, I have pcos.

there can be no other forms, nothing else has ever worked.

I’ve been on it since May, no idea on weight as I get too focused on numbers so decided not to, but my bmi has gone from 40.1 to 33.3. So at one point it did work.

i swim five times a week for 30-45 mins and cycle 20 mins to get to the pool and back. So definitely exercising.

It didn’t really kick in for me until about 7mg, then the noise went, I ate one meal a day and didn’t snack. I would feel myself getting hungrier by around Friday, with my injection day being Sunday. Now the noise is back and the willpower is gone again and I can feel myself get hungry already even though it’s Monday.

The thing is, you are MEANT to feel hungry. And if you are eating or trying to eat only one meal a day with that level of exercise, then you will be and should be, bloody starving!

Mounjaro should not cause appetite suppression to the point where you do not want to eat. That isn't how it is intended to work, (although it may for a short while after increasing a dose). Unfortunately many idiots and airheads on SM keep banging on about this aspect. That is probably because they have borderline Eating Disorders or are just parroting each other in fear of being Different From The Accepted Norm. Step away from their fuckwittage...

What Mounjaro will do is stop you from overeating and also stop cravings.

What SHOULD happen is:

You will feel hungry at mealtimes and you will want to eat at mealtimes. If you haven't eaten properly recently then you will and should feel, very hungry indeed.

You will eat a proper calorie counted meal and feel full up and SATISFIED afterwards. You will not feel the urge to overeat or to carry on eating after finishing your meal. But look - your meal must be nutritionally and calorifically adequate or you will be fighting your own body and ultimately you will lose and you will binge all your weight back on. Every binge-eater knows that the number one trigger is starving yourself...

This may be what is going on here - if you eat once a day you are simultaneously crash-dieting AND you have to consume more calories than you should need to in a single meal. Why not trust the drug to do its job and work with it and your body? Honestly, even if you got to your goal weight like this, what do you think will happen when you stop taking the drug?

You will not normally feel the urge to snack between meals, and if you do - say because you have exercised a lot - then a small nutritious snack will be perfectly sufficient. If you get a craving for more or for junky stuff, then you will be able to say No. This is not the same as getting hungry at meal times - hunger is not the enemy, cravings are.

As you lose weight you need to recalculate your TDEE and your calorie limit at TDEE minus 500 because it decreases. If you are constantly feeling the desire to eat way below your calorie limit then try to resist because no good can come of it in the long term and you are still in the early stages of a long journey.

You have lost a SPECTACULAR amount of weight in a very, very short time. However if you have starved your body it will be fighting back now, as well as perhaps just needing time to readjust. You say you have PCOS which can make it harder to lose weight as well as bring a higher risk of disordered eating. So please give yourself some credit, and do not worry about a stall unless it lasts longer than 8 weeks. I can't find the link but it is apparently completely normal to stall for a number of weeks when you have lost between 10% -20% of your bodyweight.

Cattie98765 · 02/01/2025 13:59

Hey OP,

A few months late on this one but hoping you’re still around…

I’m in a very similar position, been on 15mg for nearly 7 weeks now and having no appetite suppression or increased fullness. I’m wondering if I’ve become immune! Did you find a solution?

Thank you!

Shrinkingrose · 02/01/2025 14:59

How can you not know your weight, do you not have to submit it every four weeks to order your pen?

Mazzer1972 · 17/01/2025 03:19

Hi cattle, you've totally just described my situation! Have you found a solution, has it started working again?

Brightonseafront · 15/03/2025 12:57

Hi All!

firstly ..Well done everyone.. it’s so tough to lose weight , with or without jabs !!

Another late post… but same here..I started M last year and lost 4.5 stone in 10 months…( on v low calorie intake so lots of hunger understandably !), but now I’m just maintaining my weight despite max dose Mounjaro and being hungry a lot more with more food ..The appetite suppression definitely isn’t as effective as it used to be .. food noise is back ..( but I do get full quicker than I would without M)..I would love to lose one final stone but this is going nowhere ….i do spin classes and am generally active ….so don’t know where from here ..my jab day is in 2 days, and I’m tempted to take sooner which I shouldn’t ..
has anyone experienced a return of jab effectiveness after a period of sort of tolerance? (Interesting observation re temperature, as this pen did actually arrive not cold …)..any thoughts welcome ..it’s quite frustrating when you are working hard on something & stop getting results :(

missingthemidlands · 15/03/2025 16:54

I’ve started jabbing every five days. I don’t recommend as this is clearly not safe.

I really think it’s the way my jabs come and when I run out of my current supply I’m going to change providers.

OP posts:
Brightonseafront · 15/03/2025 17:23

… op how long have you been doing this, did you notice improvement ? Any deterioration of side effects? After having had an incredible bowl of gnocchi with blue cheese& Parmesan ( I regret nothing 😂- kind of sorry but not sorry), i now decided to take M on day 5 instead of 7 ovcasionally when I need to ( like today, prior to gnocchi !), and providing I feel okay( no side effects etc… I didn’t have side effects before, apart from being slightly down).. I’ll see how this goes….( I’m wondering if jabs nearing their expiry date might lose their potency ?!).

Brightonseafront · 16/03/2025 14:45

Hi..following my previous post, just wanted to discourage others from taking the jab sooner than it’s due… I took mine on the morning of day 6 and I feel so awfully nauseous, I won’t do that again. I also feel terribly down, much worse than the bit of low mood i experience normally ..ugh…
Stay safe everyone.. (if anyone is reading).

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