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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Developing Tolerance

2 replies

LaineyCee · 09/07/2024 16:17

I wanted to share my experience and ask if others have experienced something similar.

I’ve been taking Mounjaro for a few months now, moving up dose at the end of each pen. I’m about to start on 10mg.

Initially, when I started on 2.5mg it was a real struggle to eat enough to meet my protein and nutritional needs. All intrusive thoughts about food were gone.

Now, although I am at a higher dose of MJ and eating much more food (only slightly below maintenance level) I am really feeling hungry. Once again, I’m spending my days thinking about food, talking about food, salivating over online menus…. Waking up in the middle of the night desperate for breakfast…. Counting the hours to dinner when I’ve only just finished lunch.

In the past, I have taken both Saxenda and Ozenpic and have noticed the same thing. The longer I take the drug for, the less its effect on me.

There are so many stories on here from people who have continued on the same dose throughout, so I know this problem doesn’t affect everyone. But I wondered if others have experienced it, or if there is any published research on tolerance and GLP-1 medications…?

Concerned that eventually, even at the highest dose, MJ will no longer offer any benefit to me….

And having felt freedom from food obsession, I don’t want to go back.

Would really welcome your thoughts.

OP posts:
justsaxy · 10/07/2024 21:53

I noticed similar on Saxenda, so I reduced and maintained at 1.8 dose, and I have only recently switched to Wegovy.
I am taking inspiration from people who have been on it for over a year and have lost steadily.

TheShellBeach · 10/07/2024 21:55

I don't know the answer but there are two higher doses available to you still.

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