We're a reserved lot down here in the South-East. Don't be surprised if you meet people, become friends and are never invited into their homes. If you do get an invitation then you know you're considered a true and close friend!
Don't misunderstand the use of the word "quite" here. In the US it seems to be a substitute for "very", here it's used to mean the opposite. "How was that restaurant you went to on Friday?" "Oh, it was quite good." This is a polite way of saying that it was lousy.
You're from Boston so the cultural differences should be fewer than if you come from elsewhere. I hope.
We might appear to be a cold and reserved bunch but we're pretty friendly once you get under the surface.
And I'd echo what KaraKaraKodi said about the attitude to drinking alcohol here. In some circles a "good night out" means getting pissed, and that doesn't mean being annoyed with anyone. Well, not always. Even the Romans, when they invaded, thought we were drunkards. I blame it on the climate.
Get used to metric: we don't do inches and feet here anymore, or Fahrenheit.
Also, don't bother bringing any electrical appliances over unless you want to invest in a load of transformers to make them work here. Computers and similar should work but you'll need to check.
You'll probably find food more expensive here than you're used to at home.