I work full time, so does DH. I would say I have a career, I'm a business analyst for a software company, and I'm working my way up.
We have a 4yo in reception, and a 6yo in y2. They go to after school club every day, until 5.30. DH requested he start his day as early as possible which means he works 8-5, and he does pick up from ASC. I work 9-5.30 also by request, and I WFH full time, so I do drop offs. We live close enough to school so it's a five minute walk which helps a lot. I travel occasionally for work and so does DH.
In terms of managing day to day, the kids don't do any evening clubs at the moment. DH does most of the cooking, and we do meal planning and an online grocery shop together on a friday evening usually. I do most of the laundry, and until recently we had a cleaner who came once a week, I'm in the process of trying to replace her at the moment. We're working on getting the kids to tidy up after themselves, and the state of the house is a constant battle at the moment.
In the evenings, DH picks them up, he cooks dinner while I do reading and homework with the kids/clean up the kitchen around him/fold laundry/tidy up etc.
Grandparents are about 40 minutes away. They do have them for a day here and there in the school holidays, but are too far away for after school care. DH's sister stays with us often, and she will care for them in the evening, or on a weekend if we want to go out occasionally. The rest of holidays are managed with annual leave and a holiday club run by the after school club.
So we manage, with some paid for help, and a bit of family help which I am very very grateful for. I do sometimes feel the kids miss out on things, I'd like them to go to cubs or sports clubs or whatever, but it's just not practical with our working hours at the moment. In a couple of years I might be able to reduce my hours a bit, and allow the kids to do those things, but at the moment money is too tight for us to really think about that.
It's taken a lot of effort on both sides for me and DH to set ourselves up to work like this, he was as proactive as me about requesting hours of work that fit with family life, he changed jobs recently and rejected a few potential roles because the commute would be too disruptive or the hours wouldn't work. We're a team, which is the main thing that makes it work.