I've done it when dc has been off nursery through illness or nursery closure... it's not easy but annual leave isn't unlimited and with school holidays to cover needs must.
When he was little and still bf it was fine, a lot of teams calls with a sleeping/BFing baby just out of shot and when he was awake I just sat on the floor with him and some toys.
As he's gotten older it's almost impossible, at 2 he needs full attention. When we have to do it me and dh take 'shifts', so one has the toddler and the other works then we swap so dc gets one of us 100%- he still makes regular appearances on video calls though, everyone I work with knows him and will stop the meeting to say hi or fawn over whatever adorable toddler weirdness he's doing in the background. I imagine not all workplaces would be that accommodating and understanding though.
I wouldn't recommend trying to do it full time but as a one off or occasional thing it's doable.