It will be really hard. While you might be more physically adept with a newborn, having experience, the main thing I found difficult was the guilt.
I felt really bad for dd, my PFB, when ds was born. At the same time, felt desperately sorry for ds, never getting the same amount of attention. Spent a lot of time sobbing and alternatively bigging up dd and ds.
But then I tend to be a blubbering wreck after birth, so you may be guilt/tear free.
They are now 3.5 and 18months and it is much easier.
It did help that while dd was an appalling sleeper for the first year, ds was much better (probably because he was left to his own devices much of the time?).
Also, nothing can prepare you for how different babies are - dd fed like a dream, ds less so. DD very smiley and coy, ds a lunatic whirlwind toddler.