Bonniej - you've got a few areas there but all miles from each other and very different!!
Wilmslow is lovely and recommend it but it's not cheap there - about the same as here I think so a 3-bed semi would be upwards of £250K. DH works in Wilmslow and I've quite a few friends there. You are brilliantly located 5 mins from Manchester airport, not far from Trafford Centre, great big John Lewis and M&S 5 minutes away and then you are just 5-10 mins away from Alderley Edge and Prestbury.
I personally would not choose to live in Irlam, Widnes, Leigh (lived close by in Wigan as a child - OK parts but as someone else said, you'd have to be very careful about where). The only thing I know about Newton-le-Willows is that my best friend was a languages teacher at the secondary school there and it's terrible - now on special measures. I don't know anything about the actual area though.
My choice would def be Wilmslow out of those but as I say, not cheap.
There are loads of other places you could consider that are not too far from Wilmslow and actually that little bit closer to Warrington are Altrincham, Sale and Lymm. I'd recommend all of those (but then I would as I live Alt/Sale way!). Altrincham and Sale are not particularly cheap either but have brilliant schools throughout and you really can't go wrong with any of the primaries. Also have 2 or 3 of the best state Grammar schools in the country if that would be a bonus to you. Again only 10 mins from airport, M6, Trafford Centre, The Lowry. You are also on the Metrolink which takes you straight into Manchester so that is a real bonus. You are also just 10 mins away from lovely countryside and there is Tatton Park and Dunham Park close by (we go to Dunham a lot because it's a great open space for the kids). House prices vary but generally, again, a 3-bed semi will cost you over £250K and could be as high as £300K around the really good schools.
HTH, let us know if you want any more info!