query re use of aspirin first trimester after two consecutive miscarriages

[Skattycatty123]

Hi there, ive recently found out im pregnant again after two miscarriages. Im on progesterone pessaries and the gp has prescribed Aspirin but basically only because i pushed for it, he (and a consultant he discussed it with) said there was no indication i need to take it, no risk factors and no known blood clotting disorder. Got pregnant before i could get tests for aps etc done. Ive read conflicting advice on Aspirin, in particular that it can actually be harmful to take in first trimester if no known blood clotting disorder. I was wondering if anyone has any experience of this type of situation and what you have been told by gp/consultant etc.

Thank you for your help xx

Hey , if I was you I’d would definitely take it , 75mg low dose , I have had 5 early losses and I got told to take aspirin low dose in my next pregnancy when I get pregnant again , this was nhs consultant for recurrent misscarrige who told me that , it absolutely doesn’t hurt , only can help ! It helps by increasing the blood flow to the baby and stops bloods clots from forming inside the baby’s tiny veins ! I will 100% take it next time I’m pregnant , good luck 😚

Also I don’t have any blood clotting disorders but was still advised to take it ! I heard 100s of successful stories of woman taking it after recurrent misscarriges and were successful !

I took it under the miscarriage clinic. In my successful pregnancy I was on 150mg a day plus a cocktail of other stuff including a huge dose of progesterone. It’s worth a go. What harm do you think it could do?

So much about how they treat recurrent miscarriage seems to be art rather than science. I had all the tears during my 5mcs and no cause found but my very experienced consultant is sure a lot more women have clotting disorders they can’t get diagnose so treats most of his patients as though they have them and in 18 years he’s had a small handful of women not have a successful pregnancy.

Wishing you every luck.

@Skattycatty123 totally agree with @Sadgirl28 . I’ve had two back to back MC (going through second as we speak) and I’ve also read hundreds of stories of people who were successful with low dose asprin after many unexplained losses. I’m planning to take it on my next one at 150mg as I’ve read it’s more effective but still classed as a low dose. @Sadgirl28 I’m so sorry it’s taken 5 losses for you to find out about the baby asprin. I hope it works for you next time. It seems you didn’t get good support as most people are referred to RMC after 3 losses. I’m keen to get on progesterone supplements as well but have no hope of being prescribed it after having only two losses.

@Slk3558 hey , thanks for your message ! I was reffered to recurrent misscarrige clinic after 4 losses , and they found nothing wrong , the basic NHS testing . But I only found out about aspirin after 5 losses when the specialist told me to 100% to try as nothing was wrong ! Sometimes your blood clots only in pregnancy but not when not pregnant . I am also hoping to go on progesterone but consultant didn’t mention it so maybe I’ll beg him myself next time I get pregnant , anyways he reffered me to ivf route now thinking it’s chromosome issues , even though I hardly belive this , 5 in a row chromosome problem , I don’t think so , I am in my 20’s as well . So I don’t know how ivf is going to help when I get pregnant myself but just lose them so . Hopefully they will give me some medicines if I have ivf , hopefully I’ll get pregnant by myself before ivf

I was prescribed low dose aspirin and high dose folic acid - I have two children now - follow the doctor but my miscarriage expert obstetrician said these were the two things she prescribed her ladies first

@Slk3558 sorry about your loss it’s heartbreaking , I know it all toooo well unfortunately

@custardbear hey , did you have any losses before you had you two babies ? X

I had 3 mc and had an appointment to see the recurrent miscarriage clinic but it was cancelled due to lockdown. I then got pg again and took 150mg aspirin and the result is now lying next to me, 5 weeks old! At 20 weeks pg, the midwife referred me to a consultant and he said to stop taking the aspirin as I hadn’t been officially diagnosed and the guidelines say not to unless officially diagnosed - despite the fact I might have been diagnosed were it not for lockdown and the anecdotal evidence of 3 mc then a successful pregnancy with aspirin. I weighed up all the factors and decided to carry on. It’s prescribed if you have 2+ risk factors for preeclampsia anyway and I had one (age). I believe it’s also recommended for ivf pregnancies. I 100% believe it made the difference in my pregnancy continuing.

Good luck, it’s such a scary time in early pregnancy after MCs

Hi thanks for your replies . @Slk3558 and @Sadgirl28, I managed to get progesterone pessaries by emailing my gp the link to the tommys miscarriage association leaflet where they mention the newest trial showing it has some benefit for women that have had miscarriages/bleeding. they thn had to ask gynecology for advice, and gynecology agreed to the prescription, and ultimately the gp then prescribed it to me, to start taknig the day of my bfp. so, i basically started testing extremely early just so that i could phone gp on the day of any hint of a line, which i did and started taking 2 pessaries twice a day since then. hope this makes sense! xx

@Starlight39 that’s great to hear your success story, I’ve heard many like yours and there’s no way it’s a coincidence- I’m not sure why all the medical research papers and trials have showed no benefit of asprin for preventing losses, they must have been starting it too late or something because there’s no way I can accept that it a coincidence after reading so many women with recurrent mc having gone of low dose asprin and having successful pregnancies. There’s just too much evidence from these testimonies. I will 100% be taking 150 mg when I get my BFP. did you take it before implantation or when you got your BFP?

@Sadgirl28 I agree 5 in a row unlikely chromosomal , I’m also 27 and find it hard to accept two back to back mc can be caused by ‘chance’. They said it can be caused by genetics that get passed down to once the eggs been fertilized - so it’s not a bad egg as such but when you make the embryo from egg and sperm it becomes bad because it inherits your genetic chromosomal problem. But I’ve heard this is not common. When you get pregnant again (which you will) please let me know how it goes and whether the asprin is helpful.

@Skattycatty123 wow I can’t believe you convinced your GP for the progesterone- I’m on my 2nd mc and asked them if they’d prescribe it next time and got a flat out NO got told I’d have to endure a third loss and then the specialist mc clinic would decide the best course of action for me. They’re a joke. Could you email the link to that trial paper I would like to have on hand because I’m interested in progesterone supplements as well and might try n get it on a private prescription. Best wishes for your pregnancy so let us know how it goes with the asprin and progesterone Xx

@Skattycatty123 sorry not email I’m so used to dealing with emails, could you just share the link on here if you can xx

@Slk3558 hey, yes I will keep you updated , I am 28 Neally same as your age , but yeah my 5 losses are ridiculous , all happening at the same time 5-6 weeks . When I had my 3rd and 4th loss , nobody at gp or recurrent clinic told me to take aspirin or never got offered anything but just good luck and try again ! I can’t belive it , and I did try again 5 th time without no help and lost it again same time . I just can’t belive why they didn’t give me a plan for next pregnancy as simple as aspirin as progesterone , so when I get pregnant next time , number 6 , I will demand progesterone !! Or go private ! I feel like I am the doctor here not them . I know more than they do ! how can they say good luck and go try again after 4 losses ???? Without any support , it just is ridiculous ! Probably because nhs testing came back normal so they didn’t ! But don’t doctors know that even if testing is all normal that you can still give hope to woman and offer something ,or a plan for next pregnancy , at least something that might make a different but won’t harm you !!! Example aspirin and progesterone , it’s been researched for years and years and I’m surprised that doctors don’t even mention it sorry long post but it really gets me angry how they treated me

I was prescribed aspirin and progesterone after one loss. Took them both every day from positive test and still lost the second one. I'm now 13 weeks pregnant with only occasionally taking progesterone and no aspirin. I've also read entry of other women still losing whilst on it. Its hard to know what is just a coincidence but I did what I thought was right for me.

@Baileys123 hey , sorry about your losses and so glad your pregnant now and things going well , I understand what you mean about aspirin and progesterone , but sometimes some pregnancys REALLY has chromosome problems and no matter what you do , it would fail anyways . I think the real evidence comes from people who have lost 3,4,5+ Pregnancy’s and then suddenly it all works out after taking aspirin and progesterone :)

I have a friend who lost 4 pregnancy’s in a row 5-6 weeks and 5 th pregnancy she took aspirin and progesterone and it all worked out ! One of her pregnancy tissue was tested and it was chromosome normal , so found no other issues . So she tried aspirin and progesterone and all worked out . It’s very unlikely to have 5 misscarriges by chance , but 1-2 I understand but not 5 x and also can I ask how did you get progesterone and aspirin after just one loss ? Normally GP do not give until after 3 losses ? I’m just curious if you don’t mind

@Sadgirl28 - yes I had 3 first trimester miscarriages snd about 5-6 positive pt then period came within a week or two so non starters

@Slk3558 I took the aspirin from when I got a BFP rather than from ovulation. I took 2 x 75mg ones at night and then took my other vitamins in the morning in case there was any interaction. Good luck with everything, miscarriages are heartbreaking .

@Sadgirl28 you have every right to feel anger and frustration. It’s clear you’ve been let down by the system..when you hear so many stories of women have unexplained recurrent losses - even where tests don’t show anything , they’re still prescribed asprin / progesterone because they know it does work for a lot of people (even if medical clinic trials haven’t shown it’s effectiveness they must see so many success stories which is why they continue to prescribe it!) . I’m truly sorry you’ve had to endure that many losses and ended up virtually prescribing yourself . I feel frustrated that i can’t get help after two so I can only imagine how you feel.

I take it you can get pregnant relatively quickly ? Have you heard the theory about being super fertile and your uterus accepting bad quality eggs at implantation instead of chucking them ? I’ve been reading about that but even that doesn’t add up to me because why would he be ovulating consecutively bad eggs - then that just boils down to egg quality again and I don’t accept that at our age .

I had two first trimester losses in 2019, after my second I found out I had a gene mutation called MTHFR which is quite common and can cause miscarriages, it’s all to do with how your body processes folic acid/folate and can increase your chances of having a clotting disorder.

For my successful pregnancy I was on aspirin, progesterone, had cut out synthetic folic acid from my diet and was on pregnancy multivitamins that had the right form of folate for me.

My baby is 4 months old next week and he’s perfect.

Hope all of you have a successful pregnancy soon

@Slk3558 hey , I don’t get pregnant very easily , maybe once a year so I don’t think I am super fertile .

@Sadgirl28 sorry for making that assumption. It must have been so hard for you . I wish you all the best and sincerely hope you get pregnant soon and have a successful pregnancy. I’m just finishing up the second mc now and bought some low dose asprin for the next BFP so will keep updated xx

Hi @Montii that’s interesting I have read about MTHFR I think I might invest in some methyl folate supplements just in case my body is having that issue. Thanks for sharing. X

@Slk3558 hey I also have bought some pre natal vitamins which include the folate , to take for my next pregnancy , just incase I have the MTHFR mutation gene , i did a lot of reading and it’s always better to take folate instead of folic acid , folic acid is cheap . I am already taking my new prenatals, hoping it will help me get pregnant as wel , I read a lot of amazing reviews of the prenatals I bought , they have folate inside as well which is exactly what I wanted and also very organic , it’s called zahler prenatal , I think it’s about £30 for one months supply but it’s very good quality and natural ingrediants I love it ,

@Sadgirl28 thanks, makes you wonder why women not encouraged by NHS to take natural folate supplement as oppose to folic acid. Why we have to bury ourselves in research to figures these things out ?!?

@Slk3558 I totally understand , i feel like I am the doctor here and educating my doctor about the reasons I could be Having misscarriges if I get pregnant again and aspirin works then I will cry because I could have saved 5 pregnancy’s over something that costs pennies !!!

I had it under treatment from a miscarriage clinic too along with pregnancy vitamins, extra vitamin D, omega 3, progesterone pessaries and steroids. My specialist said to take low dose aspirin up to 25 weeks pregnant. It’s a precautionary measure in case your clotting issues start when you’re pregnant. Just be prepared that you might be asked if you’re pregnant when you buy it from the chemist and they might refuse you it!