We wrongly assume that joint pain is due to hormone deficiency. We forget that our joints are aging. Men suffer the same joint deterioration and muscle loss. It’s just our bodies normal regeneration process slowing down. They are moving parts and continuous use over a period of time eventually causes natural wear and tear.
our cells have predetermined number of times that they can divide to maintain an organ or tissue. So it follows that by the time we reach our 50s some of these processes are slowing down or that cells are no longer dividing.
The endocrine system is complex and relies on complicated feedback systems. Our estrogen and progesterone levels remain pretty constant until we actually go through menopause. Our monthly cycle would fail if they are not at the level that controls the cycle but the ovaries need increasingly higher levels of the hormones that stimulate the production of estrogen and progesterone. A gradual rise in FSH is needed to stimulate production. But there is a lack of research into the mechanism and the focus has always been to supplement rather than investigate the underlying cause of symptoms. If HRT works why look for other solutions.
Since many endocrine glands actually reduce output when the end hormone is replaced, corticosteroids are one such mechanism, then HRT may well be interfering with normal production in perimenopausal women. There may be more effective ways to increase natural hormone production by coming at it from a different direction. Certainly the evidence is emerging that women starting HRT in perimenopause seem to need to increase the dosage to maintain the effect, suggesting the body is no longer maintaining the levels naturally.
I started HRT probably just as I was going into post meno so the low dose was fine And I ticked over.
Going back to the feedback mechanisms, when people take prednisone at high doses their body shuts down corticosteroid production because it recognises that the levels are high. Unfortunately under stress the body then fails to respond and they go into adrenal crisis. I have always wondered whether taking estrogen and progesterone, particularly the biocompatible versions has a similar effect shutting down natural production when the feedback mechanism suggests that levels are ok.
I was considering testosterone supplements to try a deal with the muscle pain and had discussed it with my GP who was happy to prescribe, but COVID hit then I was diagnosed with breast cancer.
The joint pain I have now is different to the problems I had during peri menopause. The muscle pain has eased. The hormone blockers I take cause fluid retention within the joint. It moves around and is worse with some manufacturers version than others. It also affects the joints bilaterally. Currently it’s both knees. The first joints affected were my elbows. Sometimes my wrists cause problems but it’s not consistent. I’ve change manufacturers again ( not by choice it’s usually whichever is available) and my knees are improving.
During perimenopause it was more muscular but I did notice a massive improvement when I started magnesium supplements. I take them until the symptoms improve then stop restarting them when symptoms appear. I’m now retired so have a much healthier diet. No eating on the run or convenience foods, so my dietary magnesium is better. I drink l ess caffeine and more water. My 40s and 50s were hectic and stressful.