Feeling very low on Evorel Sequi

[Underthestairsbears]

Does anyone else have this problem. I'm coming to the end of my first 3 months on this medication and so I've had a good try.
The two weeks on Evorel 50 are fine but the two weeks on Everol conti are making me feel almost suicidal. Not suicidal though... but very dark thoughts.

Every little thing makes me cry... I wanted HRT to help with my moods and periods the most (as well as various other reasons) but I'm a mess.

I've made an appointment for a phone consultation tomorrow but have pulled the plaster of misery off my derrière and I have no idea if that's good or bad.

A word of encouragement or a little support would help me so much now.

Long term poster with recent name change x

Also why do people not notice when you're feeling miserable?

I help my friends out with all their woes but I can't remember the last time anyone asked how I was.

Hi OP, I have this too. Except I get anxiety and can’t sleep. Then, after 12 days of no sleep, I get a complete brain fog. The cumulative effect over a few months has been horrendous. It is an intolerance to progesterone- there is no effective treatment as you need progesterone if you are in HRT and have a womb. I am considering a hysterectomy- that is how bad I feel.

Thanks so much for getting back to me.
It's horrible isn't it. I'm only 44 and am feeling just old and miserable!

I couldn't sleep the other night because I was planning a really simple trip to the cinema and KFC and literally got so stressed and anxious about it. This isn't me!

First month on Evorel Sequi for me. Start 2nd box tomorrow morning. I've been very surprised that I've been OK with Conti patches. I, in the past, haven't tolerated the POP, birth control implant, even Agnus Castus. They've all made me super depressed or very angry.

Makes me wonder if I have a bad batch lol

OP, I hope the Dr is able to suggest something that suits you better 🤞

Thanks @Annasgirl and @superblondie28

If I could just have the Evorel 50 I'm sure I'd be ok. Apparently it takes 5-12 hours for norethisterone to leave your system so hopefully I'll feel a bit better tomorrow.

Im like this on the progestogen part of the cycle

I have heard that there’s an option to take progesterone vaginally, so that it heads straight to the required area and there’s less of it circulating in your system at large 🤔

God it's a minefield isn't it!

I found the Conti patches difficult to deal with. I spoke to the Nurse Practitioner at my GP Surgery and now have an oestrogen gel pump to use in addition to the patches. This has largely solved the majority of the issues I was having with joint aches and low mood. Mostly just use 2 pumps of gel a day but can go up to 3 or 4 if needed so I can adjust accordingly.

And 💐 as it really is such a hard thing to deal with. But honestly after a month of the gel pump, I can honestly say that my anxiety has gone. Definitely worth a try.

Thank you @friendshipfloss
Honestly if I didn't have mumsnet to ask I don't know what I'd do!

If you switched to gel/patch oestrogen you could try Utrogestan (possibly vaginally) or a Mirena coil.

I have a Mirena, having been very wary for years, and tolerate the progesterone this way very well. It doesn’t make me low

Exactly the same here op and I’m loosing my hair even more than pre hrt.
Spoke to gp this morning who said stick with it as only 2 months in and think about buying regaine for my hair.
I also have more headaches on the conti patches too, all in all like pmt.
I’m taking the mini pill so that limits my hrt choices atm.

If you are well in the first 2 weeks you may be reacting to the progestogen component in the second type of patch so could try an Evorel patch with either Utrogestan (micronised progesterone) capsules in the second part of the month, these are body identical so may be less likely to cause side effects, or you could have an Evorel patch with a Mirena coil, this is often recommended for younger women as it provides contraception but is a very low dose as it goes direct to the endometrium

So glad I found this thread, I could have written it myself. For 2 weeks I'm ok then I het my period, fatigued and been experiencing massive clots passing suddenly (have been checked, nothing nasty) then I start the other patches and my mood is so low and I'm tearful and irritable and feel lonely and angry all.at once.

@Summer776 you're not alone. Stopping them when I posted this has made me feel so much better. God knows what it'll do to my cycle but GP said I did the right thing. She wants me to have a break for two weeks or so and then get checked over - BP etc and then try gel with a tablet in the evening.
It's definitely a thing isn't it. It honestly was getting to be scary how down I got, it was worse by the 3rd month.

Hopefully you'll get something else, just keep telling yourself it's the patch not you. 🍫🍫🍫 Sending you 🍫🍫🍫

@Underthestairsbears thank you for replying. I will make an appointment this week if possible

Urgh only done one month, the 2nd 2 weeks are horrific just the worst PMS symptoms ever

Hi
Just came on to say I’ve stopped using the patches as I feel they turned me into an emotional /anxiety ridden wreck with not much benefit.only thing they seemed to help was joint pain!

Sympathies, OP, it can be a right faff getting your HRT dose balanced.

I’m on a sequential regime using Oestrogel and Utrogestan capsules currently although it’s now 12 months since my last natural period so technically I could go to a continuous regime.

I reacted to the Utrogestan (increased anxiety, which is already a problem for me) but after some experimentation I’ve settled on one capsule of Utrogestan each night for 12 days per month, delivered vaginally. I’m less anxious during the progesterone phase now and I am having a bleed 3 - 4 days after the end of the 12 days, so the dose is doing its job of making sure my womb lining doesn’t get too thick.

Ah, just noticed this is an old thread. Oh well, hope it’s useful to someone anyway 🤷🏽‍♀️

It's all helpful.

I was expecting to be offered progesterone for vaginal application to try.

I've had womb ablation which would hopefully help prevent the thickening anyway plus I would sometimes go 3 months without periods.

I may ask for a private referral to one of the clinics, it should be covered by my work health plan.

I just want to sleep better and feel 30 degrees at night and for my PMT symptoms to not be horrific. 🤣

Hey @AwkwardSquad very helpful! I need to discuss this tonight. Feel a bit low that the HRT I’m on is making me feel worse.

I’m on Evorel Conti. More than two months now. I feel my energy is better but I am absolutely fucking miserable some of the time and have churning anxiety in my body sometimes too - both noticeably since starting on the patches.

Feel gutted because I don’t want to get the coil. But the only other options for progesterone are coil or utrogestan vaginally (I tried it orally and it made me feel like a zombie - like I’d been drugged into a state of brain fog and exhaustion).

How is it taking Utrogestan vaginally? And - sorry TMI question - how does it affect sex, do you have to insert it after sex or doesn’t it matter?

Hi , I’m the same when it comes to my progesterone part of the patches I’m very anxious and very very weepy , I’d love to have the gel as well as my patches , but I was told that if you increasing the oestrogen ( by adding a gel as well ) then you have to increase your progesterone with it ??

@friendshipfloss I want to ask my GP about this. But I was aware if you are increasing the oestrogen ( with gel pump on top of patches ) then you have to increase the progestogen, so wouldn’t it have the same affect ?