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Doxycycline

40 replies

NailsHairNipsHeels · 21/02/2026 01:26

I’ve been prescribed doxycycline for a sinus infection that just won’t clear up on its own, was given this one as I’m allergic to penicillin.
The prescriber really emphasised the possible side effects and I then looked it up when I got home and now I’m a bit worried about taking it! I’ve purposely delayed starting it as I’m out all day tomorrow with young children so didn’t want to risk upset stomach etc
is it as bad as I’ve read about? I’ve to take a 5 day course and obviously want rid of the sinus issues but I’m a bit reluctant to make myself feel worse given the absolute horror stories I’ve read about this antibiotic!
DP described it as evil!

OP posts:
Blueskiesnotgrey · 21/02/2026 01:29

I've had doxcylcine before and it was fine except it makes you extra sensitive to the sun and I got bad sunburn. I wouldn't worry about that now if you're in the Uk ..

CoffeeBeansGalore · 21/02/2026 01:33

You have to be careful with timing regarding food.
I was prescribed it once & was constantly feeling & being sick. I've refused it since.

NailsHairNipsHeels · 21/02/2026 01:37

i’m in Scotland I think I’ve forgotten what the sun looks like!
I have IBS and a bit of a sensitive stomach at the best of times I went and got probiotics and started them today, my plan is to start the antibiotics on Sunday and I’m hoping the probiotic lessens any stomach issues.
after I read the horror stories I thought to myself I’d rather take the penicillin and be itchy/feel sick!

OP posts:
ThatFairy · 21/02/2026 06:01

I've had it, I was absolutely fine. And yes probiotic drinks really do work. I've been suffering from severe very painful acid reflux for the past two years after taking a course of amoxicillin. I tried yakult in the past week and it has massively improved my symptoms. I am super happy about it

Peclet · 21/02/2026 06:14

it have taken it. Works brilliantly and no side effects. I think it says to take it and lay down for a short while after if possible??
can’t quite remember but that stuck in my mind. Basically take it. Stay still for a bit. Then you’re fine.

SixteenFortyeight · 21/02/2026 07:03

Peclet · 21/02/2026 06:14

it have taken it. Works brilliantly and no side effects. I think it says to take it and lay down for a short while after if possible??
can’t quite remember but that stuck in my mind. Basically take it. Stay still for a bit. Then you’re fine.

Please double check this, OP. I just came on to say that you must read the instructions on the sheet inside the box carefully as I'm pretty sure that whatever you do, you must take it with something and definitely not lie down afterwards but remain upright. I have a strong memory of taking an antibiotic (I'm almost certain it was doxycycline) a few years ago; it was the morning dose and I was so sick that I just took it with a mouthful of water and lay back down in bed. Lying down caused oesophagal 'burns' and it was SO painful and took some time to heal. DP, whose work involves administering medication, knew exactly what had happened and could point to the line in the fact sheet which stated, with unambiguous clarity, that each dose must be taken upright and that one ought not to lie down for X period after taking a dose.

I also experienced photosensitivity, including when driving at night with dazzling lights, as well as some tingling and prickling in my fingers. It all wore off after some time.

The dose got rid of a very persistent infection when nothing else had worked.

Another word of warning, more generally, about antibiotics: please take the full course, and seek GP advice and reassurance as opposed to stopping the course if you experience side effects. We have so few effective antibiotics left and it is all of our responsibility to protect their integrity and guard against antibiotic resistance -one of the ways we ensure efficacy is to complete courses. I hear people express the misconception that antibiotic resistance is an individual thing -that it the patient that develops antibiotic resistance when taking antibiotics incorrectly. This is incorrect: antibiotic resistance refers to how an antibiotic becomes less effective for all of us as the spectrum of bacteria it is designed to treat becomes resistant and learns to 'work around' the prescribed antibiotic when inconsistent use allows, rendering it ineffective and allowing infection to persist unchecked. Subsequent infection by the same pathogen in other individuals carries the risk of prescribed antibiotics not working, which is terrifying, given how much we need reliable antibiotics in medicine, not just in general practice.

Also, re penicillin allergy. Please don't dice with this: if you've already experienced adverse reactions to a course of penicillin, chances are they will be exacerbated by future exposure and you could become seriously unwell, necessitating stopping the course and thus compromising the efficacy of penicillin in terms of antibiotic resistance. I'm allergic to penicillin and learnt my lesson when ignoring the itchy hives I'd experienced during a previous course, and ended up with a very severe reaction following a new prescription some years later. I was told by hospital staff that I must never take penicillin again.

Ladyymuck · 21/02/2026 08:29

I’ve just finished a course of doxycycline and it was fine. Read the instructions carefully. For me it was really important I took it after my main meal of the day as otherwise I felt really sick. It’s also very important not to lie down after taking it and iirc you should make sure you leave at least 2 hours before you go to bed after taking it.

NewAgeNewMe · 21/02/2026 08:33

I get a metallic taste with it. I’m prescribed it a lot. Repeated chest and sinus infections that penicillin never touches the sides of. I put up with the metal taste as it’s so good at getting rid of my infection. I’ve got a course to start on Friday after a ct sinus scan first.

REDB99 · 21/02/2026 08:33

Do NOT lie down!!!!

You must stay upright for at least 30 minutes after taking it. If you do this side effects linked to irritation of the oesophagus will not happen.

NewAgeNewMe · 21/02/2026 08:34

Also I case you have missed pp said

be upright when taking it and for 30 minutes after! Very important.

danij5873 · 21/02/2026 08:36

I took this and it made me throw it straight back up (literally within about 10 mins) got no other side effects (obviously…it wasn’t absorbed) and refused to take any more but weirdly my headaches completely stopped from that day! (I was experiencing cluster headaches, Dr thought it could be sinus infection so prescribed me that)

OchreSnail · 21/02/2026 08:37

I was given this for the same reason as you, and had the same concerns! The boys sounded pretty scary and I was worried about feeling sick, faint etc.

I had a 10 day course, took the tablet after my evening meal, and had no problems at all, if that helps at all.

danij5873 · 21/02/2026 08:40

But just to say I bet I didn’t read the instructions very carefully, I didn’t know they were anything different and from memory I took not long after getting back from work (so probably before food) so I’m sure if you read the instructions carefully you’ll be fine!

RedRosie · 21/02/2026 08:59

I had to take this for three months re a tricky dental issue a few years ago. It was absolutely fine. I followed the advice about staying upright for 30 mins after taking it. I don't remember any side effects at all, so hopefully that will be the case for you.

SeaToSki · 21/02/2026 09:01

I took it for 6 weeks as an antimalarial. I had no side effects at all and didnt bother overly about taking it with food etc (as I was camping in Africa). If you have acne, it can be very helpful in treating that, I also didn’t notice any skin sensitivity, but i was using sunscreen every day anyway as I was in Africa! Bit everyone is slightly different.

NailsHairNipsHeels · 21/02/2026 10:02

I did read to take it with plenty water and to stay upright after taking it I get horrendous acid reflux so I’ll definitely do that to avoid any more discomfort! It’s reassuring that so many have had minimal side effects. I just need to take it and keep my fingers crossed. I most definitely will take the full course I’m rarely unwell enough to need any medication so I’m pretty good at sticking to the rules plus I just want to feel properly well again.
if I wasn’t so busy today I’d have taken it as soon as I got home from the chemist!

OP posts:
BitterlyLemon · 21/02/2026 10:10

Worked brilliantly for me - I actually felt better than I had ever felt (to the extent I was googling whether people take it long term!). Definitely take it with food (after a meal) and a whole glass of water/drink. I also have a sensitive tum and had no problems following those instructions.

MyBestThing · 22/02/2026 12:04

I've had it and it certainly gave me some gastric symptoms, mainly diarrhoea.
Pointless taking probiotics beforehand as the ABs will just destroy them. Start as soon as you finish and have some kefir and sauerkraut or similar as well.

Sugarnspicenallthingsnaice · 22/02/2026 12:21

Good luck OP. I can't keep it down.

DoIdriveaVauxhallZafira · 22/02/2026 12:26

Sensitive stomach here also, have had to take Doxycyline long term and absolutely no problems - not even sunburn.

Your gut will probably respond more to the anxiety about taking it than the tablets themselves.

Generally, I don't read about side effects unless I think I could be experiencing one. Doctors & pharmacists will always flag anything you need to be pre-warned about. No point in worrying over nothing.

IbizaToTheNorfolkBroads · 22/02/2026 12:41

Doxycycline comes straight back up for me. It makes DM hallucinate!

Good luck @NailsHairNipsHeels. Don’t make any important plans.

whereisitnow · 22/02/2026 12:49

Peclet · 21/02/2026 06:14

it have taken it. Works brilliantly and no side effects. I think it says to take it and lay down for a short while after if possible??
can’t quite remember but that stuck in my mind. Basically take it. Stay still for a bit. Then you’re fine.

It says the opposite. Don’t lie down for a period. It may be 30 minutes, but do check.

And follow the rules on the packet for eating with it . Then it’s fine.

Bumpinthenight · 22/02/2026 12:49

My first doxy came straight back up, horrendous nausea for the first two days with a splitting headache and then I felt OK.

It advises you to take it on an empty stomach. After losing the first one, the GP said to have it with a meal.

boulevardofbrokendreamss · 22/02/2026 15:37

I had no side effects at all.

julesagain · 22/02/2026 16:10

As Amoxycillin no longer works for me with chest infections as I take immunosuppressents, I am prescribed Doxycycline which works well but I suffer bady with photosensitivity so I can't take it in the Summer, which i haven't had to for a few years.

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