Sorry about the delayed response. I was out all day. I'm playing catch-up now and I've only got as far as Jo's post from Sunday at 12.41. I will post this response and then read on.
Jo, I'm not sure why you think I would have a problem with an animal study (aside from animal welfare issues) given that I was talking about a rabbit study and other animal studies mentioned in the ATSDR report in an earlier post. Your other comments about dismissing studies based on race, age or eye colour are ridiculous and completely unfounded.
Your first link is a study investigating the clearance of aluminium from the injection site and the features of the lesions that were found around the injection site. It does not, as you've said, mention Al being excreted nor does say that it 'remains bound up near the injection site'. It states that lesions were observed and that there were higher concentrations of Al, particularly in the area of the lesions that persisted for up to 12 months (the longest time before the monkeys were sacrificed). They were localised at the injection site rather than in surrounding muscle tissue. The study only examined quadriceps muscle sections. It does not examine other areas of the body to determine whether any aluminium was retained from the vaccines elsewhere.
Your second link states this wrt safety of Al in vaccines:
"A recent review of the evidence of adverse events after exposure to aluminium-containing vaccines against diphtheria, tetanus, and pertussis (DTP), found no evidence that aluminum salts cause any serious or long-lasting adverse events.7"
It is based on this study
which focuses on observable effects such as induration, swelling, fever and says that it found no evidence for serious or long lasting adverse effects (with them). It also follows that statement with "Despite a lack of good-quality evidence we do not recommend that any further research on this topic is undertaken." which doesn't exactly inspire confidence!
I am not looking for a guarantee of safety. I know that isn't possible and tbh I would be very wary of someone telling me that it was 100% safe. I would, however, like to know how it has been deemed safe.
I do not think my questions are unreasonable. People on this thread have said a few times that 'the dose is the poison' but yet none of you seem to be able to say what that dose is for Al in vaccines. None of you seem to know what the excretory capacity for Al is in a healthy child (beyond which excess Al is deposited in tissues around the body) so therefore none of you seem to know whether a dose of Al in a vaccine exceeds either of those. I'm actually not sure why any of you think you are in a position to say that Al is 'safe' tbh.
Bruffin, I'm sure that you think the studies that you linked to 'show that Al levels in vaccines is safe' but as I explained above, they do not actually provide enough information for you to conclude that. One the them shows that the 'alpha hydroxy carboxylic acid from interstitial fluid is capable of dissolving aluminium containing adjuvants' but the experiments were not done at typical body concentrations or temperatures and no information is given about how much it is capable of dissolving( more/less than in a vaccine?) and how it may differ under typical body concentrations and/or temperatures.
The other refers to the flarend et al rabbit study and states that "in vivo mechanisms are available to eliminate aluminium-containing adjuvants after i.m. administration." although it omits other findings from the study such as:
""Following intramuscular administration of aluminum hydroxide or aluminum phosphate vaccine adjuvants in rabbits, increased levels of 26Al were found in the kidney, spleen, liver, heart, lymph nodes, and brain (in decreasing order of aluminum concentration) (Flarend et al. 1997)."
and doesn't say how much is eliminated and how much is retained. I did give you a quote from the ATSDR report which looked at other studies which show that 27% of the dose is still retained after 5 days.