Gooseberrybushes Tue 19-Jul-11 11:32:43
"There is currently no evidence for a link."
Now that's what I call absolutist. There's MASSES.
Remember that thread - you said you were looking for links to scientific papers? Didn't look that hard huh? They're there.
Not least thousands and thousands of parents reporting a link. Once might be called a coincidence. Ten times could be carelessness. Thousands and thousands? Whoops sorry - I forgot that you KNOW they're all wrong. Every last one of them. You KNOW that. So what they say doesn't count.
Thanks for your constructive help. I have looked at the two scientific papers that I can find suggesting a link and given a very convincing arguments why they are flawed (supported by the GMC and several critiquing consultants.
Here is a list of references that when critiqued show that MMR and regressional autism are separate issues:
Department of Developmental Services. Changes in the population of persons with autism and pervasive developmental disorders in California's developmental services system: 1987 through 1998. A Report to the Legislature. California Health and Human Services, March 1, 1999. Available at: www.dds.ca.gov/Autism/pdf/autism_report_1999.pdf. (Accessed on January 18, 2006).
Dales L, Hammer SJ, Smith NJ. Time trends in autism and in MMR immunization coverage in California. JAMA 2001; 285:1183.
Madsen KM, Hviid A, Vestergaard M, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med 2002; 347:1477.
Madsen KM, Lauritsen MB, Pedersen CB, et al. Thimerosal and the occurrence of autism: negative ecological evidence from Danish population-based data. Pediatrics 2003; 112:604.
Kaye JA, del Mar Melero-Montes M, Jick H. Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis. BMJ 2001; 322:460.
Yeargin-Allsopp M, Rice C, Karapurkar T, et al. Prevalence of autism in a US metropolitan area. JAMA 2003; 289:49.
Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009; 65:591.
McCormick MC. The autism "epidemic": impressions from the perspective of immunization safety review. Ambul Pediatr 2003; 3:119.
Wakefield AJ, Murch SH, Anthony A, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998; 351:637.
Wakefield AJ, Montgomery SM. Autism, viral infection and measles-mumps-rubella vaccination. Isr Med Assoc J 1999; 1:183.
Bernard S, Enayati A, Redwood L, et al. Autism: a novel form of mercury poisoning. Med Hypotheses 2001; 56:462.
Bernard S, Enayati A, Roger H, et al. The role of mercury in the pathogenesis of autism. Mol Psychiatry 2002; 7 Suppl 2:S42.
Geier, MR, Geier, DA. Thimerosal in childhood vaccines, neurodevelopment disorders and heart disease in the United States. J Am Physicians Surg 2003; 8:6.
Geier MR, Geier DA. Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication. Exp Biol Med (Maywood) 2003; 228:660.
Iñiguez C, Mauri JA, Larrodé P, et al. [Acute transverse myelitis secondary to hepatitis B vaccination]. Rev Neurol 2000; 31:430.
Herroelen L, de Keyser J, Ebinger G. Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine. Lancet 1991; 338:1174.
Marshall E. A shadow falls on hepatitis B vaccination effort. Science 1998; 281:630.
Classen JB, Classen DC. Clustering of cases of type 1 diabetes mellitus occurring 2-4 years after vaccination is consistent with clustering after infections and progression to type 1 diabetes mellitus in autoantibody positive individuals. J Pediatr Endocrinol Metab 2003; 16:495.
Classen, DC, Classen, JB. The timing of pediatric immunisation and the risk of insulin-dependent diabetes mellitus. Infectious Dis Clin Pract 1997; 6:449.
Byrd, RS, Segman, M, Bono, M. Report to the Legislature on the principal findings from the epidemiology of autism in California: a comprehensive pilot study. University of California, Davis, M.I.N.D. Institute, October 17, 2002. Available at: www.ucdmc.ucdavis.edu/mindinstitute/newsroom/study_final.pdf. (Accessed on March 8, 2006).
Croen LA, Grether JK, Hoogstrate J, Selvin S. The changing prevalence of autism in California. J Autism Dev Disord 2002; 32:207.
Wing L, Potter D. The epidemiology of autistic spectrum disorders: is the prevalence rising? Ment Retard Dev Disabil Res Rev 2002; 8:151.
Shattuck PT. The contribution of diagnostic substitution to the growing administrative prevalence of autism in US special education. Pediatrics 2006; 117:1028.
Uhlmann V, Martin CM, Sheils O, et al. Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol 2002; 55:84.
Retraction--Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 2010; 375:445.
Deer B. How the case against the MMR vaccine was fixed. BMJ 2011; 342:c5347.
Murch SH, Anthony A, Casson DH, et al. Retraction of an interpretation. Lancet 2004; 363:750.
Stratton, K, Wilson, CB, McCormick, MC (Eds). Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism. National Academy Press, Washington, DC 2001.
Offit, PA. Vaccines and autism. Immunization Action Coalition, www.immunize.org (www.immunize.org/catg.d/p2065.htm). (Accessed on January 18, 2006).
Fombonne E, Chakrabarti S. No evidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics 2001; 108:E58.
Offit PA, Coffin SE. Communicating science to the public: MMR vaccine and autism. Vaccine 2003; 22:1.
Taylor B, Miller E, Lingam R, et al. Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ 2002; 324:393.
Evans AS. Causation and disease: a chronological journey. The Thomas Parran Lecture. 1978. Am J Epidemiol 1995; 142:1126.
Immunization Safety Review: Vaccines and Autism. A report of the Institute of Medicine. The National Academy Press, Washington, DC 2004.
Kawashima H, Mori T, Kashiwagi Y, et al. Detection and sequencing of measles virus from peripheral mononuclear cells from patients with inflammatory bowel disease and autism. Dig Dis Sci 2000; 45:723.
Fernell E, Fagerberg UL, Hellström PM. No evidence for a clear link between active intestinal inflammation and autism based on analyses of faecal calprotectin and rectal nitric oxide. Acta Paediatr 2007; 96:1076.
Bitnun A, Shannon P, Durward A, et al. Measles inclusion-body encephalitis caused by the vaccine strain of measles virus. Clin Infect Dis 1999; 29:855.
McQuaid S, Cosby SL, Koffi K, et al. Distribution of measles virus in the central nervous system of HIV-seropositive children. Acta Neuropathol 1998; 96:637.
Martin CM, Uhlmann V, Killalea A, et al. Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder. Mol Psychiatry 2002; 7 Suppl 2:S47.
Afzal MA, Ozoemena LC, O'Hare A, et al. Absence of detectable measles virus genome sequence in blood of autistic children who have had their MMR vaccination during the routine childhood immunization schedule of UK. J Med Virol 2006; 78:623.
D'Souza Y, Fombonne E, Ward BJ. No evidence of persisting measles virus in peripheral blood mononuclear cells from children with autism spectrum disorder. Pediatrics 2006; 118:1664.
Katz SL. Has the measles-mumps-rubella vaccine been fully exonerated? Pediatrics 2006; 118:1744.
Hornig M, Briese T, Buie T, et al. Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. PLoS One 2008; 3:e3140.
Cass H, Gringras P, March J, et al. Absence of urinary opioid peptides in children with autism. Arch Dis Child 2008; 93:745.
Nagamitsu S, Matsuishi T, Kisa T, et al. CSF beta-endorphin levels in patients with infantile autism. J Autism Dev Disord 1997; 27:155.
Gillberg C, Terenius L, Lönnerholm G. Endorphin activity in childhood psychosis. Spinal fluid levels in 24 cases. Arch Gen Psychiatry 1985; 42:780.
Gillberg C, Terenius L, Hagberg B, et al. CSF beta-endorphins in childhood neuropsychiatric disorders. Brain Dev 1990; 12:88.
Feldman HM, Kolmen BK, Gonzaga AM. Naltrexone and communication skills in young children with autism. J Am Acad Child Adolesc Psychiatry 1999; 38:587.
Willemsen-Swinkels SH, Buitelaar JK, van Engeland H. The effects of chronic naltrexone treatment in young autistic children: a double-blind placebo-controlled crossover study. Biol Psychiatry 1996; 39:1023.
Willemsen-Swinkels SH, Buitelaar JK, Weijnen FG, van Engeland H. Placebo-controlled acute dosage naltrexone study in young autistic children. Psychiatry Res 1995; 58:203.
Baird G, Pickles A, Simonoff E, et al. Measles vaccination and antibody response in autism spectrum disorders. Arch Dis Child 2008; 93:832.
Schonberger LB, Bregman DJ, Sullivan-Bolyai JZ, et al. Guillain-Barre syndrome following vaccination in the National Influenza Immunization Program, United States, 1976--1977. Am J Epidemiol 1979; 110:105.
Murphy TV, Gargiullo PM, Massoudi MS, et al. Intussusception among infants given an oral rotavirus vaccine. N Engl J Med 2001; 344:564.
Miller E, Waight P, Farrington CP, et al. Idiopathic thrombocytopenic purpura and MMR vaccine. Arch Dis Child 2001; 84:227.
Taylor B, Miller E, Farrington CP, et al. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet 1999; 353:2026.
DeStefano F, Bhasin TK, Thompson WW, et al. Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan atlanta. Pediatrics 2004; 113:259.
Mäkelä A, Nuorti JP, Peltola H. Neurologic disorders after measles-mumps-rubella vaccination. Pediatrics 2002; 110:957.
Patja A, Davidkin I, Kurki T, et al. Serious adverse events after measles-mumps-rubella vaccination during a fourteen-year prospective follow-up. Pediatr Infect Dis J 2000; 19:1127.
Peltola H, Patja A, Leinikki P, et al. No evidence for measles, mumps, and rubella vaccine-associated inflammatory bowel disease or autism in a 14-year prospective study. Lancet 1998; 351:1327.
Smeeth L, Cook C, Fombonne E, et al. MMR vaccination and pervasive developmental disorders: a case-control study. Lancet 2004; 364:963.
Fombonne E, Zakarian R, Bennett A, et al. Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics 2006; 118:e139.
Mrozek-Budzyn D, Kiełtyka A, Majewska R. Lack of association between measles-mumps-rubella vaccination and autism in children: a case-control study. Pediatr Infect Dis J 2010; 29:397.
Honda H, Shimizu Y, Rutter M. No effect of MMR withdrawal on the incidence of autism: a total population study. J Child Psychol Psychiatry 2005; 46:572.
Wilson K, Mills E, Ross C, et al. Association of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence. Arch Pediatr Adolesc Med 2003; 157:628.
Farrington CP, Miller E, Taylor B. MMR and autism: further evidence against a causal association. Vaccine 2001; 19:3632.
DeStefano F, Mullooly JP, Okoro CA, et al. Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitus. Pediatrics 2001; 108:E112.
Infections and vaccinations as risk factors for childhood type I (insulin-dependent) diabetes mellitus: a multicentre case-control investigation. EURODIAB Substudy 2 Study Group. Diabetologia 2000; 43:47.
Heijbel H, Chen RT, Dahlquist G. Cumulative incidence of childhood-onset IDDM is unaffected by pertussis immunization. Diabetes Care 1997; 20:173.
Karvonen M, Cepaitis Z, Tuomilehto J. Association between type 1 diabetes and Haemophilus influenzae type b vaccination: birth cohort study. BMJ 1999; 318:1169.
Hviid A, Stellfeld M, Wohlfahrt J, Melbye M. Childhood vaccination and type 1 diabetes. N Engl J Med 2004; 350:1398.
Graves PM, Barriga KJ, Norris JM, et al. Lack of association between early childhood immunizations and beta-cell autoimmunity. Diabetes Care 1999; 22:1694.
Blom L, Nyström L, Dahlquist G. The Swedish childhood diabetes study. Vaccinations and infections as risk determinants for diabetes in childhood. Diabetologia 1991; 34:176.
Hyöty H, Hiltunen M, Reunanen A, et al. Decline of mumps antibodies in type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of type 1 diabetes after introduction of the mumps-measles-rubella vaccine in Finland. Childhood Diabetes in Finland Study Group. Diabetologia 1993; 36:1303.
Levitsky LL. Childhood immunizations and chronic illness. N Engl J Med 2004; 350:1380.
Centers for Disease Control and Prevention (CDC). Progress toward elimination of Haemophilus influenzae type b invasive disease among infants and children--United States, 1998-2000. MMWR Morb Mortal Wkly Rep 2002; 51:234.
Centers for Disease Control and Prevention (CDC). Progress toward eliminating Haemophilus influenzae type b disease among infants and children--United States, 1987-1997. MMWR Morb Mortal Wkly Rep 1998; 47:993.
Smith MJ, Ellenberg SS, Bell LM, Rubin DM. Media coverage of the measles-mumps-rubella vaccine and autism controversy and its relationship to MMR immunization rates in the United States. Pediatrics 2008; 121:e836.
The measles epidemic. The problems, barriers, and recommendations. The National Vaccine Advisory Committee. JAMA 1991; 266:1547.
Feikin DR, Lezotte DC, Hamman RF, et al. Individual and community risks of measles and pertussis associated with personal exemptions to immunization. JAMA 2000; 284:3145.
White CC, Koplan JP, Orenstein WA. Benefits, risks and costs of immunization for measles, mumps and rubella. Am J Public Health 1985; 75:739.
Gangarosa EJ, Galazka AM, Wolfe CR, et al. Impact of anti-vaccine movements on pertussis control: the untold story. Lancet 1998; 351:356.
Friederichs V, Cameron JC, Robertson C. Impact of adverse publicity on MMR vaccine uptake: a population based analysis of vaccine uptake records for one million children, born 1987-2004. Arch Dis Child 2006; 91:465.
Johnson RT, Griffin DE, Hirsch RL, et al. Measles encephalomyelitis--clinical and immunologic studies. N Engl J Med 1984; 310:137.
Weibel RE, Caserta V, Benor DE, Evans G. Acute encephalopathy followed by permanent brain injury or death associated with further attenuated measles vaccines: a review of claims submitted to the National Vaccine Injury Compensation Program. Pediatrics 1998; 101:383.
Roos RP, Graves MC, Wollmann RL, et al. Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis. Neurology 1981; 31:1263.
Brooks, GF, Butel, JS, Morse, SA. Paramyxoviruses and rubella virus. In: Jawetz, Melnick, & Adelberg's Medical Microbiology, 21st ed, Butler, JP, Ransom, J, Ryan, E (Eds), Appleton & Lange, Stamford, CT 1998. p.50.
Id be happy to help you access them