Page 4 | Sertraline support

BrickSnail · 2026-02-26T14:29:11+00:00

Hi all, I'm on day 4 of sertraline and the side effects have been absolutely horrific. I've gone through so many old posts on this but was wondering if anyone was currently in the same boat so we could support each other?

Lizzbear · 21/04/2026 06:07

VictoriaSmith01 · 21/04/2026 05:57

Thanks everyone. I’m on day 7 and whilst I have moments of feeling ok I also feel quite down and flat. I am using tools I learnt in CBT to tackle my intrusive thoughts and anxiety spirals, which is what I’ve always done before starting mediation.

I’m wondering if the Sertraline isn’t for me as I’ve never really felt down before, and I’m worried it’s close to feeling depressed. I’m getting way more agitated with my kids.

I told myself I’d give it two weeks but I really don’t want to continue feeling down or flat…

I’m sorry you’re feeling down but it’s a common side effect of starting ssris to feel worse before you feel better. I’m probably about 10 days in on my increased amount of sertraline and feeling a bit worse, but have had moments of feeling better than before. So, I think we need to leave it a minimum of 4 weeks for it to really start to work.

indigorising · 21/04/2026 21:35

5 days x 25mg. 30 days x 50mg.

The anxiety was resolved swiftly. The low mood, flatness and extreme fatigue are still a feature. If it wasn’t for the absence of the anxiety I would find it difficult to persist with the medication.

I would expect now to begin to experience a consistent softening of the low mood and a return of motivation. I’m hopeful.

Watch this space.

Lizzbear · 21/04/2026 21:47

indigorising · 21/04/2026 21:35

5 days x 25mg. 30 days x 50mg.

The anxiety was resolved swiftly. The low mood, flatness and extreme fatigue are still a feature. If it wasn’t for the absence of the anxiety I would find it difficult to persist with the medication.

I would expect now to begin to experience a consistent softening of the low mood and a return of motivation. I’m hopeful.

Watch this space.

Keep on it and hopefully that will happen. I found 50 wasn’t enough and am on 100. But 50 was enough for a few years.

Anon3837 · Yesterday 14:52

Anyone go higher than 100mg?

week 5-6 now and horrible side effects settling, other than insomnia and jaw clenching/teeth grinding. I am feeling a little better.

GP states I can increase if I need to…up to 200mg! Anyone above 100? I also worry about libido loss, which I didnt experience at all with Citalopram…in fact, I’d say the opposite lol!!

hope everyone is getting on well.

stick with it in the early weeks. Weeks 1-3 were the hardest for me.

VictoriaSmith01 · Today 06:00

Day 9 of 25mg here and I think I might be over the worst of it!? Definitely feel lighter than before and the tummy upset has settled, appetite also returned. GP wants me to increase to 50mg but I’m trying to avoid this by using a variety of methods; excercise, diet, meditation, breathing work, journaling etc. Let’s see x

Lizzbear · Today 06:37

VictoriaSmith01 · Today 06:00

Day 9 of 25mg here and I think I might be over the worst of it!? Definitely feel lighter than before and the tummy upset has settled, appetite also returned. GP wants me to increase to 50mg but I’m trying to avoid this by using a variety of methods; excercise, diet, meditation, breathing work, journaling etc. Let’s see x

It’s good to settle on the lowest amount, however, I think 50 is the lowest therapeutic recommendation. I’m on 100 but was in 50 for a few years and think it lost its effectiveness.