Hi everyone, hope you are keeping well. I have had depression (& anxiety) on and off since was 15. Sometimes I went many years with being well. I was treated on and off with Prozac which worked. After i had my 2 chilldren I stayed on it longer term. (lots of misscarriages & IVF so helped me be stable). When I turned 45 , 3 years ago Prozac stopped working. It was around the same time as I got the coil in for adenomyosis. I am high doeses of HRT and have tried 7 different anti depressants. I have been on: Prozac; Mirtazapine; Venlablue; Lexapro; Strethaline; Lithium; and now Lofepramine. I started Lofepramine in September and finally thought it was working but have had 2 episdoes over the past month. I am honestly at my wits end oscialating between ending it all, giving up all medication or getting a new physciatriast. I hontestly can't do another year like this one. Apoloiges my thoughts are so negative. I am tired of seeing my partner, kids and wider family worry although I mask it a lot i just cant this time. I wish I could just flip a switch and get over myself and my bad thoughts. Any help or hope would be hugely appreciated.