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What would you do?…

4 replies

MarmadukeM · 16/11/2025 10:33

Hiya so to keep this short as possible I am coming off mirtazipine and switching to trazodone. Mostly to help sleep and anxiety. I also take Vortioxetine, pregabalin and quetiapine.
so my GP wrote to psychiatry for advice and guidance and they recommended a cross taper where I go to 50% of my mirtazipine (so from 15mg to 7.5mg) for one week and simultaneously start the trazodone at 50% of the target dose (75mg) then one day 8 I stop mirtazipine and increase trazodone to 150mg.
this is all in the letter that I can see in my records.
The problem I have is that my GP has told me to decrease the mirtazipine for one week and on day 8 stop it and then start the trazodone.
I have done 4 days of this but I don’t feel great and I honestly think I’d be better off doing what psychiatry said.
Would you cross taper now or do what the GP said and just stop it first? I dont know what to do for the best but personally I’d prefer to cross taper so I am at least getting the other one in my system….
any advice/experiences would be appreciated! X

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WheresBillGrundyNow · 16/11/2025 10:46

I would do as the psychiatrist said.
I feel for you, as I know what those kinds of meds are like when you switch/ come down off them.
I hope you get through it soon and the new meds work better for you.

MarmadukeM · 16/11/2025 15:28

@WheresBillGrundyNow ah thanks, yeah its a long and uncertain process 😖

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mynameiscalypso · 16/11/2025 15:31

I’d cross taper personally. I will add though that trazodone is by far and away the best medication that I’ve been on. The only issue that I have is that you must take it every night because withdrawal kicks in very quickly if you skip a dose. That aside, it’s been a miracle for me.

MarmadukeM · 16/11/2025 20:35

@mynameiscalypso thats good to hear! Bipolar depression is a fucker 😖😂
im good with my medication, im shit scared to miss any of it incase the wheels fall off (more than they already have ha ha )

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