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Increased mirtazapine anxiety

4 replies

TildaSwan · 13/06/2025 17:41

I've been taking 30mg mirtazapine for around 6 months and although it's been really effective at reducing anxiety, it hasn't touched the sides of my low mood/lack of motivation. I increased the dose to 45mg a week ago, but my anxiety is back with a vengeance - racing thumping heart, jittery, agitated and obviously, no signs of improved mood. I don't know whether to continue with the increased dose or drop back to 30mg. Does anyone have any experience of this and does it get better? I can live with low mood but the anxiety is debilitating, to the point of not being able to leave the house due to panic. Strangely, when I increased the dose from 15mg to 30mg I felt amazing with no side effects at all!

OP posts:
Jollyjollyjollygoodie · 14/06/2025 01:45

I’ve felt better on mirtazapine since I dropped down to 15mg. It’s a strange drug that seems more effective at a lower dose.

BedsitBlues · 14/06/2025 10:41

Who’s prescribing it?
It loses its sedative effect when you increase the dose. That’ll be why the anxiety has gotten worse.

TildaSwan · 14/06/2025 11:51

Thanks for your responses. It's my gp prescribing. It IS a strange drug, at 45mg it's only hyped up my anxiety. I did a bit of reading yesterday aboyt It - something about at higher doses it works on noradrenaline(?) Which is good for depression but heightens anxiety.

@Jollyjollyjollygoodie can I ask if you take another med alongside mirtazapine? Or have you just stuck to the 15mg?

OP posts:
BedsitBlues · 14/06/2025 13:34

I’m on 15mg.
My GP didn’t want to increase because of losing the sedation - I need it mainly for sleep- so she added a different antidepressant in the morning. That GP is relatively good with mental health but even she was copying what I was previously prescribed by a psychiatrist.
I honestly don’t trust GPs to prescribe these kinds of meds. Unfortunately a lot of the time these days it is almost impossible to get in front of a psychiatrist if you’re not at crisis point.
It seems to be becoming quite common for GPs to prescribe mirtazapine, which I think is kind of strange because it’s not a go-to drug for psychiatrists. They usually get around to prescribing it where there’s treatment resistance/ other things haven’t worked. Partly because it often comes with side effects that can affect quality of life (weight gain/ increased appetite/ fatigue/ poor concentration/ brain fog etc) so it needs to be “worth it” so to speak and partly because it doesn’t work like other antidepressants, it usually works best in a “cocktail” with other meds. I had never heard of anyone being on mirtazapine alone until fairly recently and then it’s always a GP prescribing.
Is there any chance you could a referral to see a psychiatrist?

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