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Mental health

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Original poster

Sertraline 50mg to 100mg struggling 😔

3 replies

L0309 · 22/04/2025 12:11

Hi all,

I went from 50 to 100mg this week and I’m feeling terrible! No motivation can’t sleep and feel so tired.

I didn’t feel like this when I was on 50mg but that dose stopped working after a while.

just looking for other people’s experiences as I’m feeling a bit lost.

OP posts:

PostRaphaelite · 22/04/2025 20:26

Much sympathy. It’s really hard getting the dose right. What time of day are you taking it? I had problems sleeping when I took Sertraline in the evening but have been fine taking it in the morning.

Could you try taking 75mg for a while to see if that’s enough to be effective without so many side effects? I find if my dose is too high I get very tense and unable to concentrate.

SophieB0012 · 22/04/2025 20:29

I went from 50mg to 100 and had a while of the same side effects I got when first taking it. Bad sleep, teeth grinding, night sweats, racing thoughts etc but after a few weeks that all died down and I was grateful to be feeling really well! I took it in the morning rather than at night as the night time side effects weren't quite as bad.

4 years later I decided to stop it altogether as I felt I didn't need it anymore, tapered off over a few months and now another few months later I miss feeling so content and stable! Might start it again but will have to put up with the rubbish feeling for a few weeks 😫

abracadabra1980 · 23/04/2025 21:30

I've gone from 50mg to 75mg to 100mg and back down again. As with all of these SSRI/SNRI type drugs, the climbing onto them and upwards in dose can be challenging and very uncomfortable, but if you hit the sweet spot with the dose, they can be life changing. I twitched like blithery on Sertraline (only when relaxing to go to sleep) and the dreams were quite mad. I also had night sweats occasionally. The biggest problem I feel I had was the constant yawning. It was in another level and didn't really improve h less I went down to 25mg. I'm staying on 25mg as I've actually got a little of my 'normal' emotions back. I lost my dad 18 months ago and I was not able to shed a tear. Prior to that I was crying every day. It's a fine line at times, I guess...

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