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Mental health

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Original poster

Treatment resistant depression

6 replies

Englishrose223 · 13/07/2024 18:04

I suspect I have this. 20 years of shit mental health. Have tried citalopram, sertraline, respiridone, pregablin, venlafaxine, diazepam. Have had years of counselling- cbt, dbt, Schema Therapy, EMDR, probably others I don't remember. Diagnosed depression anxiety and dysthymia. Losing hope I'll ever be well. Right now I just don't care about anything. Don't want to do anything. Is anyone able to share any hope?

OP posts:

Inlaw · 13/07/2024 18:10

Englishrose223 · 13/07/2024 18:04

Sorry to hear this OP. Oxford are doing new trials for treatment resistant depression. And apparently there are really hopeful about it and it’s already licensed as safe for other uses. So that is very hopeful. Maybe you can contact and see if/ when/ how they are trialling and whether you would be eligible.

www.psych.ox.ac.uk/news/ketamine-may-offer-hope-to-those-with-treatment-resistant-depression

Inlaw · 13/07/2024 18:13

Oh and you can actually pay private?! https://www.oxfordhealth.nhs.uk/ips/ketamine-trd/

Might be worth looking at!

Ketamine TRD

Ketamine is a licensed anaesthetic drug. It can also work as an antidepressant but has not been licensed for this use. A closely related version, nasal esketamine, does have a licence but has not been…

https://www.oxfordhealth.nhs.uk/ips/ketamine-trd

Turkeyhen · 13/07/2024 18:14

Also psychedelics for treatment resistant depression could be worth investigating: there may be clinical trials recruiting?

There's a thread in AMA about microdosing that may be worth a read too.

whatisforteamum · 13/07/2024 18:16

I read an article about how people had treatment resistant depression yet they discovered they were autistic.
I told my ds who felt no different taking ADs.

Sajacas · 13/07/2024 18:56

Please watch this,
And take a look at this; https://www.youtube.com/@metabolicmind

Best of luck.

Georgia Ede MD - What is nutritional and metabolic psychiatry #PHC2023

Filmed on the 19th & 20th May 2023 at the Public Health Collaboration Annual Conference in Sheffield. World-renowned speakers convened to share their experti...

https://www.youtube.com/watch?v=23_fnung5To

rw34 · 14/07/2024 22:24

Hi EnglishRose, I am not able to share any hope but just wanted to say that my experience is the same as yours. I have had years of counselling. I have tried lots of different antidepressants over the years. I've done CBT and life coaching sessions. I've tried drastically changing my diet, so no processed food.
Not only does nothing help me, some things like CBT, changes to diet and exercise routine make me feel worse. This is because I am autistic. Medication also affects me differently, I either have really strong reaction to Medication or it doesn't do anything at all. Life coaching only made me realise that I am already doing everything I can to manage my disabilities.

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