I've been on sertraline now for 4 weeks today and I definitely see the difference but there is a few issues I take it at night as it helps with sleeping and then I wake up in the morning motivated and ready to conquer my jobs for the day and positive but then it gets to 3ish pm and I'm stairing at walls feeling hopeless feeling like there's no point in life, like I can't cope and then come 7pm that feeling passes and I feel okay again, I definitely see more happiness in myself on the sertraline but I've also never felt so low at the same time. How long does this take to pass I dread those few hours every day I hate it and I don't want to feel like this anymore