Can anti-depressants stop working after long term use?

[CantSnapOutOfIt]

I've been on sertraline for years, stay on a maintenance dose of 100 mg and have been pretty steady for years despite a number of challenges. However I have lost interest in everything the last few months, everything either bores me or annoys me or I just can't be arsed to bother with it. I'm listless and apathetic and find no pleasure in anything. I welled up today when I saw someone having fun...and I think I twigged that I'm not right at the mo. Could my AD have stopped working? I have been on it probably 8 years. Should I up my dosage or try another AD? Anyone had a similar experience, how did you resolve it?

Hi op i can't really answer your question but I have been on sertraline for 9 years and it still works for me. I'm on 100 mg a day. I have ups and downs at times and have been on a 150 mg when I was at my lowest. Maybe have a chat with your gp

I agree you should talk to your GP.
I hope you get the support you need and start to feel better soon.
I'm restarting meds so hoping I start to feel better soon... I'm finding it difficult finding pleasure in things too. I get annoyed and envious of others... it's hard.