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Venaflaxine Support/Advice Please

12 replies

Bev62 · 09/03/2021 19:00

Just completed 4 weeks of taking Venaflaxine (9days @ 37.5 & 29 days at 75mg). Don’t feel any change in mood/ anxiety as yet. Should I give up on them or is there still a chance they will start to work? Not too keen to up the dose. Dr has suggested adding Quetiapine to the mix to help with sleep.
I’m really struggling here and in a complete panic/fear that I won’t get any better.
Any positive advice/experience will be gratefully received.

OP posts:
Linearpark · 10/03/2021 10:44

Ive been on antidepressants for about 30 years, several different ones beginning with the old style amytryptaline with its delightful side effects. They are not addictive, ive tapered off them easily for weeks or months at a time on several occasions, but i became depressed again each time as i have intrinsic depression which will need to be treated permanently, which is not usually the case, i think a year or two works well for a lot of people.

Anyway I've been on venlafaxine for several years now. In my experience the mood doesnt improve for several weeks with these modern antidepressants which have very few side effects however. To be honest, i think the older style amytryptaline made me feel somewhat better quite quickly because, besides the dry mouth and urinary retention, the other side effect was basically zonking out after taking them each night. I think i felt better just because there was some relief from the terrible insomnia i had and rest from the constant pacing around of thought in my mind.

Anyway it takes time. On the other hand, your dose seems miniscule to me. I have seen a psychiatrist who upped my dose from 150 mg to 225 mg as he correctly determined it was not reaching a therapeutic dose. The difference was quite marked. Whilst i am in no way recommending a dose as high as mine, i do wonder if you are having a therapeutic dose. Or maybe, if the dose is lower it could take longer to start working. I know two other people on vanlafaxine and they are both on 150 mg which works very well for them. A quick look at the British National Formulary will show you the dosages advised so may be worth checking how dosage is determined. This is something i would encourage you to discuss with your gp in an open manner. I have always done so with many different drs over the years and they are always happy to take your feedback on side effects and efficacy into account.

Finally, you can and will get better! This is an illness with symptoms affecting not only body but also the mind in all its aspects, all due to unusually low concentrations of certain neuro transmitters. Venlafaxine is good antidepressant as it boosts both seratonin and noradrenalin by slowing their breakdown. Give it a few weeks if you can. Discuss pros and cons of increased dose. You may then try another one as some work for some people not others, thats true, but its a little early to determine that yet i would suspect. Hope this helps.
"Darkness visible" by william styron helped me a lot if you have any concentration, which i know is extremely difficult, but its a short book and rich in content so even reading the odd paragraph may help. Just because when you read it you know he understands and it helps you see that you can and will recover.

Tehmina23 · 10/03/2021 12:05

I take 337.5mg Venlafaxine MR and I've gone from constantly seeing the darkness in everything & constantly feeling suicidal to generally feeling quite happy!
I won't lie, I do get 'down' days & I felt quite depressed around December & January but not like I used to be & not suicidal.

For example I can be depressed for an hour or so then I feel the Venlafaxine kicking in & lifting my mood.

Regarding anxiety, I had some work related anxiety & panic attacks over the past few weeks & was prescribed promethazine 25mg which relaxed me but I was able to keep working.
The anxiety is related to the paranoia I get with Schizoaffective disorder though. Luckily the anxiety has settled for now.

Taking a high dose of Venlafaxine does have side effects; it affects certain muscles such as in the eye (I've had to start wearing glasses) and unfortunately the bladder (I started having accidents so now I take Solifenacin 10mg to stop that).
Also you need a yearly ECG.
Although I do take Aripiprazole as well so the ECG could be for that.

But Venlafaxine has basically saved my life so it's worth the side effects.

You may find you do need a higher dose, just keep going up slowly as recommended by the dr.
I'm unsure if the Quetiapine is for sleep - it's actually a mood stabiliser I think?

Tehmina23 · 10/03/2021 12:06

Meant to say, the Promethazine for anxiety was just prn, maximum 2 a day when required.

Bev62 · 10/03/2021 13:04

Thank you both for those positive replies. I’m very reluctant to up my dose at present as I have had and continue to get side effects. The worst being tinnitus! I should also say I am taking 15mg of Mirtazapine
at night to help with sleep.Maybe I should be patient then for a few more weeks but this feels relentless & I just want to be me again.

OP posts:
Linearpark · 10/03/2021 15:46

Thats interesting that you are also on mirtazapine. My psychiatrist also wanted to add that in at one point, and although i was literally happier than ever in my life for the couple of weeks i took it i simply couldnt cope with the side effects while i got no side effects with venlafaxine alone. I think the combination is known as californian rocket fuel.

Bev62 · 11/03/2021 15:44

@Linearpark Tks for the book recommendation. I had a skim through
it - interestingly he appears to have got better without medication and didn’t find therapy helpful.
Im having a bad day today. Very agitated and anxious . Did you get that in the early weeks? Today is the beginning of week 4 on 75mg Ven - not sleeping well which doesn’t help and very shaky. Hard to see an end in sight at the moment.

OP posts:
EnglishRain · 11/03/2021 16:03

I take 225mg too. At that level it acts differently, and it does make a huge difference for me.

ArseInTheCoOpWindow · 11/03/2021 16:07

I have some in the cupboard that I’m too scared to take.

dane8 · 11/03/2021 18:20

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Londonmummy66 · 11/03/2021 18:30

I've been on 150 mg of Venlafaxine for 15 years - I doubt I'd be here now with out it. It does sound like a low dose.

Linearpark · 12/03/2021 06:46

Before an antidepressant starts working it's hard to know if something is an illness symptom or a side effect. Besides, side effects generally become less with time.

Beckycw · 04/12/2022 21:32

How did you get on in the end? Did the tinnitus subside? I’m also having this issue

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