Have you tried multiple antidepressants and found one that worked eventually?

[9amTrain]

If so, which one?

I tried fluoxetine, citalopram at varying doses with no effect whatsoever.

They then tried mirtazapine but I came off it not long after starting as it made me feel simply awful and drugged. But maybe I should have given it longer.

I haven't been on any for years now, have just lived with it and been investigating potential other causes for depression as I wasn't 100% convinced it was purely depression in itself.

What worked for you? I'm considering something else, I just never feel right. Can't remember the last time I felt something, though I got used to it it still sucks.

And my libido is dead.

Have reoccurring episodes of depression, and over the last 8 years have tried, fluoxetine, citlapram, mirtzapine, venlafaxine, fluoxetine again and now I am on duloxetine. All tend to work for me mood wise then eventually poop out. Only one I really couldn’t get along with was the venlafaxine completely surpressed my appetite (bad thing for me) and made me sleepy through out the day.

Venlafaxine is gold standard- you need doses above 225mg to get dopamine effect as well as serotonin and noradrenaline. I take 300mg Venlafaxine and 30mg mirtazapine. I get really awful sweats from Venlafaxine but it enables me to function. Mirtazapine should be taken at night as will aid sleep due to sedation. Lots of weight gain attributed to mirtazapine and antipsychotics over the years
I’m a mental health nurse and have had bipolar 22yrs. Recently stopped aripiprazole as well due to restless legs

Have you tried 5htp. You can get it OTC or in healthfood shops/amazon. Ive been on various antidepressants over the years with varying amounts of misery and side effects, and ive now found that 200mg of 5htp at night makes me feel mostly normal without side effects and i can still feel joy too and have a sex drive, which was seemingly impossible on pr escribed antidepressants

Where Snap! Venlafaxine is a bugger for the side effects - I also get the sweats - but the combination with Mirtazapine has genuinely saved my life.

Ive taken Amitriptyline for years yet have no effects, dont think i’m taking a high enough dose.

I tried (in this order):

Paroxetine - caused vomiting
Fluoxetine - caused vomiting
Fluvoxamine - caused D+V
Reboxetine - gave me blurry vision
Duloxetine - caused drowsiness
Venlafaxine - caused vomiting
Sertraline - caused extra pyrimidal side effects
Citalopram - worked v well, but gave me sexual dysfunction and insomnia at higher doses.

Escitalopram was the one that had the best effect and the least side effects

I'm on a low dose of paroxetine. It works well for me without any side-effects & enables me to function normally. A GP once persuaded me to switch to a different one as he didn't like prescribing paroxetine but it had horrible side effects and I insisted on switching back. I think it was citalopram, it gave me the most horrendous heart palpitations & I couldn't sleep.

I've been on at various times fluoxetine (restless legs), sertraline (didn't do much), venlafaxine (horrible, I could hear my eyeballs moving in my head, and had horrendous headaches if I didn't take it dead on 24 hour intervals), citalopram for several years, was the best I've had, amitriptyline (made me cry at TV adverts) now on max dose mirtazapine, seems ok, side effects tend to be stronger at lower doses, it's more sedating at low dose, improves as you get higher. It's working well at the moment for me.

Don't be afraid to ask for something different, there are loads out there and everyone reacts differently. Doctors are used to it and will work with you. And if something isn't working for you you have every right to refuse to take it, they can't force you. I had some drs try to up my dose instead of trying something new, but if it's making things harder I won't take it.

Amitriptyline works best for me at a low dose for some reason. It might even be placebo effect but who cares? It can placebo me six ways from Sundays as long as it works somehow. And it has no effect whatsoever on libido so that's a win. Worst I've ever had from it is a couple weeks of dizziness but that resolved on its own.

I went through citalopram,fluoxetine and sertraline with tiny to small effects. The doc wanted to put me on mirtzapine but i refused as I have weight issues already and i really had to fight to get a Dr to prescribe venlaflaxine and I'm now trying to find a dosage that works for me.

FaithEverPresent and BeyondRadicalisationPortal I've been on Lofepramine for 18 years! I've never heard of anyone else being on it either!

It was first prescribed for me in 1994 for just 3 months, and it sorted me right out. When I relapsed and was a right state in 2000, they tried me with venlafaxine, fluoxetine, sertraline, amongst others and they all made me feel terrible (and most memorably, to shit my pants in Abbey National). I begged to go back on lofepramine and they kept insisting it was old fashioned and there were much better drugs on the market. Eventually I moved to a kindly GP who put me straight back on it when I asked, and I've taken 70mg a day ever since. I don't care if I take it for the rest of my life, it's the difference between feeling normal and holding down a career, and hiding in my bed crying.

I also take a very low dose of amitriptyline and propranolol, both ostensibly for migraine, but actually they boost the anti depressant/anti anxiety effect a bit. I came off the amitriptyline for a while and noticed very low mood on waking, so we reintroduced it. Definitely notice the difference.

Obvs I've got bloody pre-menopausal hormones causing irritability and brain fug at the moment, but that's a whole other thread haha!

I have tried many antidepressants. I was on 550mg of venlaflaxine and it did nothing. No side effects either. The best combo is what I have now; sertraline and lamotrigone. Sertraline helped but wasn't enough but when lamotrigone was added depression went away.

Fluoxetine - long term seemed ok
Citaliprom - didn’t work
Mirtazapine - great for sleep
Sertraline - seems ok
Now suffering with anxiety about back to work. Pains in legs and chest. Can’t move from my bed. Depression is moderate to severe - fluctuates.
I’m terrified of being off work (teacher with middle management role). Feel like a total failure if I don’t go. It’s ridiculous as I’m very well respected and great results etc. I know I do a good job but I’m literally paralysed right now.
Any help?