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Treatment Resistant Depression - is there any hope?

2 replies

Bordador · 13/04/2018 08:27

My brother has suffered from chronic depression for 7 years - he is 35, and was articulate and intelligent. He is an ex-army officer who was unable to transition to a city/finance job when he left. Since then he has mainly lived with my parents and has withdrawn from life. He still has no job, no girlfriend and he never sees his friends, nor replies to emails or telephone calls. He has no girlfriend. He's literally just a shell of his former self, existing in a state of nothingness.
He has tried numerous different tablets, he has seen psychotherapists, psychologists, CBT specialists, PTSD specialists, etc etc. He suffers from debilitating headaches (most likely stress related). It didn’t help that our mother unexpectedly died last summer, and the grief has added yet another layer to the chronic depression.

I just wondered if there is any hope? I honestly cant think how he can turn this around. He cannot look after himself so there is no way he could hold down a job. The last psychologist suggested it was Treatment Resistant Depression. It feels like a pretty bleak diagnosis. He lives with my father who is trying to cope with his own grief after losing his wife, as well as support his son. He is only just retired and I don’t think he had envisioned his retirement to be like this. I support them as best as I can too, but I live an hour away, work and have 2 children.

I just wondered if anyone had any stories of hope, or bright ideas that we can try next.

OP posts:
Babdoc · 13/04/2018 08:39

Yes there is hope. I’m a retired anaesthetist, and one of my regular hospital sessions was anaesthetising severely depressed patients for ECT. It has an 83% success rate for a first course in intractable depression. I’ve seen patients catatonic with depression - unable to eat, drink or move, soiling their beds as too paralysed by depression to even get to the loo. After ECT, they’re sitting up asking for tea and toast!
Your brother needs to be seeing a consultant psychiatrist rather than a counsellor or psychologist, in order to get an ECT referral.
There are also a range of so called “atypical” antidepressant meds that can be tried, and if absolutely everything else fails, in a tiny number of cases, patients can have a neurosurgical procedure to burn out a wee bit of the cingulate gyrus in their brain, which can be spectacularly successful.
So, don’t give up hope! The first step is to get your brother to a psychiatrist who can start exploring the treatment options.

tierraJ · 14/04/2018 18:45

I tried 2 different ADs at varying doses until being put on the SNRI drug Venlafaxine 300mg; my depression is finally much improved.

Finding the correct drug treatment can make a huge difference.

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