Cymbalta / duloxetine

[JenBehavingBadly]

I've never taken an SNRI before, just a SSRI, but the doc suggested trying this one.

Can anyone give me any stories, positive or negative about this medicine? Reviews on line are mixed, but I'd like to hear from people who've actually taken it.

Does it help with your depression? What are the side effects like? I know when I've taken sertraline or fluoxetine I've had tiredness and felt worse for the first few days. Is it similar on cymbalta?

Hi, I'm on duloxetine and have been for about five or six months. It has saved my life. It completely cured my depression.

The side effects I had when starting duloxetine were clenching of the jaw, drowsiness and increased sweating. Those side effects have gone now although I still sweat a lot.

That sounds really positive, thank you 😊 How long did it take for you to start feeling any benefit? What dose are you on now? I'm starting on 20mg, but it'll be going up to 40-60.

I got jaw clenching a lot on the SSRIs, so I expect it'll be the same.

I'm not going to lie it took about six weeks to work properly but it was worth it. It might be a lot less for you though.

I'm on 90mg. Have you taken your first pill yet?

I've been on in for 18 months.

Side effects were nausea (didn't mind that lost weight) it lasted about 3months but it was manageable.
Still going on Sweating and jaw clenching, I also bruise a lot easier which is a rare side effect. But it has changed my life! Made a huge difference to my depression. The only thing to be aware of is if I forget a dose I get very fuzzy headed and a brain zap feeling, but obviously I shouldn't be missing doses anyway.

Not yet. I've been worried about things like brain zaps and the like. I'm hoping it will finally help me get over this almost persistent depression. I've had talking therapy, I'm pretty good at mindfulness, but I just can't get out of this hole that I'm in.

I'm on duloxetine and I work well with it X

I've been on it for about 5 years and probably always will be. It absolutely saved and changed my life. I can't really say how long it took to kick in, because I was already on an antidepressant which wasn't working so did a gradual switch over.
It works well for anxiety too. Apart from a very dry mouth, I've had absolutely no side effects.
Good luck, hope you feel better soon

Worked after about 14 days of 90 mg. Works very well (depression and anxiety). Sideeffects: tired, dry mouth, hard to O, nigth sweats, vivid dreams... Ben on/off about 10 years.

How are you getting on OP? I am due to start this - scared!

Hey! I totally understand how nerve-wracking it can be to try a new antidepressant, especially moving from an SSRI to an SNRI like Cymbalta (duloxetine). I’ve been on Cymbalta for several months now, and I’ve had a really positive experience. I usually take 30 mg in the morning for the first week and then increased to 60 mg daily, just as my doctor recommended. For me, it really helps with both mood and energy levels—I’ve noticed a steadier mood throughout the day and less of that sluggish, heavy feeling I used to get with SSRIs.

As for side effects, the first few days I felt a bit dizzy and had mild nausea, but that quickly passed. Unlike my experience with SSRIs, I didn’t get that deep fatigue right away, which was a relief. I also sleep better and have more motivation for daily activities, which has made a huge difference in my overall quality of life. My advice would be to stick with it for a few weeks and keep communicating with your doctor, especially if you notice any lingering side effects—they often ease up as your body adjusts.

One important thing I’ve learned is that using high-quality Cymbalta is crucial—you really want to be sure the medication is genuine and effective.

Personally, I order mine from this trusted pharmacy: mastersupplier.net/categories/Depression/Cymbalta, and I’ve been extremely happy with the results. It gives me peace of mind knowing I’m taking a reliable product that truly works.