I have been taking 75mg of quetiapine at night for over 4 years now. The drug works well for me but I can't tolerate the weight increase anymore. I have put on a stone and can't shift any of it, I'm so scared of how out of control my weight is. I also take citalopram, lorazepam and buspirone. I have tried numerous times to reduce or come off the quetiapine and within about 5 days all my symptoms of illness come back with a vengeance. I can't seem to function without it but how fat am I going to get? My GP believes that the benefits of the drug outweigh the weight gain and quetiapine is the only anti-psychotic I can tolerate. So I feel completely stuck and increasingly depressed with my appearance. I really would appreciate anyone else's thoughts or experiences. Thanks